Palinavir | CAS#154612-39-2 | antiviral

MedKoo Cat#: 584219 | Name: Palinavir

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Palinavir, also known as BILA 2011 BS, is an antiviral that inhibits HIV-1 protease.

Chemical Structure

Palinavir

CAS#154612-39-2

Theoretical Analysis

MedKoo Cat#: 584219

Name: Palinavir

CAS#: 154612-39-2

Chemical Formula: C41H52N6O5

Exact Mass: 708.3999

Molecular Weight: 708.90

Elemental Analysis: C, 69.47; H, 7.39; N, 11.86; O, 11.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Palinavir; BILA 2011 BS

IUPAC/Chemical Name

N-((1S)-1-(((1S,2R)-1-Benzyl-3-((2S,4R)-2-(tert-butylcarbamoyl)-4-(4-pyridylmethoxy)piperidino)-2-hydroxypropyl)carbamoyl)-2-methylpropyl)quinaldamide

InChi Key

RXBWRFDZXRAEJT-SZNOJMITSA-N

InChi Code

InChI=1S/C41H52N6O5/c1-27(2)37(45-38(49)33-16-15-30-13-9-10-14-32(30)43-33)40(51)44-34(23-28-11-7-6-8-12-28)36(48)25-47-22-19-31(52-26-29-17-20-42-21-18-29)24-35(47)39(50)46-41(3,4)5/h6-18,20-21,27,31,34-37,48H,19,22-26H2,1-5H3,(H,44,51)(H,45,49)(H,46,50)/t31-,34+,35+,36-,37+/m1/s1

SMILES Code

O=C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CN2[C@H](C(NC(C)(C)C)=O)C[C@H](OCC3=CC=NC=C3)CC2)=O)C(C)C)C4=NC5=CC=CC=C5C=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 708.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lamarre D, Croteau G, Wardrop E, Bourgon L, Thibeault D, Clouette C, Vaillancourt M, Cohen E, Pargellis C, Yoakim C, Anderson PC. Antiviral properties of palinavir, a potent inhibitor of the human immunodeficiency virus type 1 protease. Antimicrob Agents Chemother. 1997 May;41(5):965-71. PubMed PMID: 9145853; PubMed Central PMCID: PMC163834. 2: Beaulieu PL, Anderson PC, Cameron DR, Croteau G, Gorys V, Grand-Maître C, Lamarre D, Liard F, Paris W, Plamondon L, Soucy F, Thibeault D, Wernic D, Yoakim C, Pav S, Tong L. 2',6'-Dimethylphenoxyacetyl: a new achiral high affinity P(3)-P(2) ligand for peptidomimetic-based HIV protease inhibitors. J Med Chem. 2000 Mar 23;43(6):1094-108. PubMed PMID: 10737742. 3: Liard F, Jaramillo J, Paris WL, Yoakim C. Pharmacokinetic aspects of palinavir, an HIV protease inhibitor, in Sprague-Dawley rats. J Pharm Sci. 1998 Jun;87(6):782-5. PubMed PMID: 9607960. 4: Ohlmann T, Prévôt D, Décimo D, Roux F, Garin J, Morley SJ, Darlix JL. In vitro cleavage of eIF4GI but not eIF4GII by HIV-1 protease and its effects on translation in the rabbit reticulocyte lysate system. J Mol Biol. 2002 Apr 19;318(1):9-20. PubMed PMID: 12054764. 5: Smart T. International Congress on Chemotherapy. GMHC Treat Issues. 1995 Sep;9(9):10. PubMed PMID: 11362904.