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MedKoo Cat#: 584215 | Name: BIIB-513

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BIIB-513 is an inhibitor of Na+/H+ exchange and has applications to vital organ blood flow.

Chemical Structure

BIIB-513
BIIB-513
CAS#265986-98-9

Theoretical Analysis

MedKoo Cat#: 584215

Name: BIIB-513

CAS#: 265986-98-9

Chemical Formula: C19H25N5O8S2

Exact Mass: 515.1145

Molecular Weight: 515.56

Elemental Analysis: C, 44.26; H, 4.89; N, 13.58; O, 24.83; S, 12.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BIIB-513; BIIB 513; BIIB513
IUPAC/Chemical Name
Benzamide, N-(aminoiminomethyl)-4-(4-(2-furanylcarbonyl)-1-piperazinyl)-3-(methylsulfonyl)-, methanesulfonate (1:1)
InChi Key
CIZHNWRBNREPCL-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H21N5O5S.CH4O3S/c1-29(26,27)15-11-12(16(24)21-18(19)20)4-5-13(15)22-6-8-23(9-7-22)17(25)14-3-2-10-28-14;1-5(2,3)4/h2-5,10-11H,6-9H2,1H3,(H4,19,20,21,24);1H3,(H,2,3,4)
SMILES Code
O=C(NC(N)=N)C1=CC=C(N2CCN(C(C3=CC=CO3)=O)CC2)C(S(=O)(C)=O)=C1.CS(=O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 515.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: An J, Varadarajan SG, Camara A, Chen Q, Novalija E, Gross GJ, Stowe DF. Blocking Na(+)/H(+) exchange reduces [Na(+)](i) and [Ca(2+)](i) load after ischemia and improves function in intact hearts. Am J Physiol Heart Circ Physiol. 2001 Dec;281(6):H2398-409. PubMed PMID: 11709405. 2: Gumina RJ, Buerger E, Eickmeier C, Moore J, Daemmgen J, Gross GJ. Inhibition of the Na(+)/H(+) exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs. Circulation. 1999 Dec 21-28;100(25):2519-26; discussion 2469-72. PubMed PMID: 10604890. 3: Rabkin DG, Cabreriza SE, Lacorte JC, Weinberg AD, Coku L, Walsh R, Mosca R, Spotnitz HM. Sodium-hydrogen exchange inhibition preserves ventricular function after ventricular fibrillation in the intact swine heart. J Thorac Cardiovasc Surg. 2003 Jun;125(6):1499-509. PubMed PMID: 12830072. 4: Gumina RJ, Newman PJ, Gross GJ. Effect on ex vivo platelet aggregation and in vivo cyclic flow with Na+/H+ exchange inhibition: Gumina, NHE-1 inhibition and platelet aggregation. J Thromb Thrombolysis. 2011 May;31(4):431-5. doi: 10.1007/s11239-010-0530-0. PubMed PMID: 21082215; PubMed Central PMCID: PMC3096849. 5: Masereel B, Pochet L, Laeckmann D. An overview of inhibitors of Na(+)/H(+) exchanger. Eur J Med Chem. 2003 Jun;38(6):547-54. Review. PubMed PMID: 12832126. 6: Wu D, Russano K, Kouz I, Abraham WM. NHE1 inhibition improves tissue perfusion and resuscitation outcome after severe hemorrhage. J Surg Res. 2013 May;181(2):e75-81. doi: 10.1016/j.jss.2012.07.026. Epub 2012 Jul 31. PubMed PMID: 22878146. 7: Wu D, Qi J. Mechanisms of the beneficial effect of NHE1 inhibitor in traumatic hemorrhage: inhibition of inflammatory pathways. Resuscitation. 2012 Jun;83(6):774-81. doi: 10.1016/j.resuscitation.2011.11.025. Epub 2011 Dec 6. PubMed PMID: 22155220. 8: Gumina RJ, Auchampach J, Wang R, Buerger E, Eickmeier C, Moore J, Daemmgen J, Gross GJ. Na(+)/H(+) exchange inhibition-induced cardioprotection in dogs: effects on neutrophils versus cardiomyocytes. Am J Physiol Heart Circ Physiol. 2000 Oct;279(4):H1563-70. PubMed PMID: 11009442. 9: Schramm W, Andel H. Ernest Henry Starling and cardiac work. Clin Exp Pharmacol Physiol. 2010 Oct;37(10):1034. doi: 10.1111/j.1440-1681.2010.05419.x. PubMed PMID: 20557317. 10: Gumina RJ, Daemmgen J, Gross GJ. Inhibition of the Na(+)/H(+) exchanger attenuates phase 1b ischemic arrhythmias and reperfusion-induced ventricular fibrillation. Eur J Pharmacol. 2000 May 19;396(2-3):119-24. PubMed PMID: 10822064. 11: Alston TA. Blockade of sodium importation in resuscitation. Crit Care Med. 2009 Jun;37(6):2126-7. doi: 10.1097/CCM.0b013e3181a5e580. PubMed PMID: 19448470. 12: Wu D, Qi J, Dai H, Doods H, Abraham WM. Resuscitation with Na+/H+ exchanger inhibitor in traumatic haemorrhagic shock: cardiopulmonary performance, oxygen transport and tissue inflammation. Clin Exp Pharmacol Physiol. 2010 Mar;37(3):337-42. doi: 10.1111/j.1440-1681.2009.05296.x. Epub 2009 Sep 21. PubMed PMID: 19769605. 13: Wu D, Dai H, Arias J, Latta L, Abraham WM. Low-volume resuscitation from traumatic hemorrhagic shock with Na+/H+ exchanger inhibitor. Crit Care Med. 2009 Jun;37(6):1994-9. doi: 10.1097/CCM.0b013e3181a0052e. PubMed PMID: 19384202. 14: Zatta AJ, Matherne GP, Headrick JP. Adenosine receptor-mediated coronary vascular protection in post-ischemic mouse heart. Life Sci. 2006 Apr 18;78(21):2426-37. Epub 2005 Nov 21. PubMed PMID: 16300799. 15: Wu D, Stassen JM, Seidler R, Doods H. Effects of BIIB513 on ischemia-induced arrhythmias and myocardial infarction in anesthetized rats. Basic Res Cardiol. 2000 Dec;95(6):449-56. PubMed PMID: 11192365. 16: Wu D, Bassuk J, Arias J, Doods H, Adams JA. Cardiovascular effects of NA+/H+ exchanger inhibition with BIIB513 following hypovolemic circulatory shock. Shock. 2005 Mar;23(3):269-74. PubMed PMID: 15718927. 17: Avkiran M. Protection of the myocardium during ischemia and reperfusion : Na(+)/H(+) exchange inhibition versus ischemic preconditioning. Circulation. 1999 Dec 21-28;100(25):2469-72. PubMed PMID: 10604882.