MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 561808 | Name: Stemazole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Stemazole is a human stem/progenitor cell proliferation activator. It has been shown to promote survival and preserve stemness in human embryonic stem cells.

Chemical Structure

Stemazole
Stemazole
CAS#317337-07-8

Theoretical Analysis

MedKoo Cat#: 561808

Name: Stemazole

CAS#: 317337-07-8

Chemical Formula: C9H9N5OS2

Exact Mass: 267.0249

Molecular Weight: 267.32

Elemental Analysis: C, 40.44; H, 3.39; N, 26.20; O, 5.98; S, 23.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Stemazole;
IUPAC/Chemical Name
N-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)hydrazinecarbothioamide
InChi Key
DSZWZHYEFYRNQI-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H9N5OS2/c10-12-8(16)11-6-3-1-5(2-4-6)7-13-14-9(17)15-7/h1-4H,10H2,(H,14,17)(H2,11,12,16)
SMILES Code
SC1=NN=C(C2=CC=C(NC(NN)=S)C=C2)O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 267.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sun Y, Zhang X, Li H, Xu S, Zhang X, Liu Y, Han M, Wen J. Stemazole promotes survival and preserves stemness in human embryonic stem cells. FEBS J. 2017 Dec 8. doi: 10.1111/febs.14355. [Epub ahead of print] PubMed PMID: 29222853. 2: Guo Z, Xu S, Du N, Liu J, Huang Y, Han M. Neuroprotective effects of stemazole in the MPTP-induced acute model of Parkinson's disease: Involvement of the dopamine system. Neurosci Lett. 2016 Mar 11;616:152-9. doi: 10.1016/j.neulet.2016.01.048. Epub 2016 Jan 28. PubMed PMID: 26827716. 3: Sun Y, Wang W, Sun Y, Han M. Synthesis and biological evaluation of a novel human stem/progenitor cells proliferation activator: 4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl) thiosemicarbazide (Stemazole). Eur J Med Chem. 2011 Jul;46(7):2930-6. doi: 10.1016/j.ejmech.2011.04.017. Epub 2011 Apr 12. PubMed PMID: 21531486. 4: Han M, Liu Y, Tan Q, Zhang B, Wang W, Liu J, Zhang XJ, Wang YY, Zhang JM. Therapeutic efficacy of stemazole in a beta-amyloid injection rat model of Alzheimer's disease. Eur J Pharmacol. 2011 Apr 25;657(1-3):104-10. doi: 10.1016/j.ejphar.2011.01.065. Epub 2011 Feb 17. PubMed PMID: 21316359.