MedKoo Cat#: 527530 | Name: MMRi64
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MMRi64 is a novel specific inhibitor of Mdm2-MdmX E3 ligase activity toward Mdm2 and p53 substrates, potently inducing p53-dependent and p53-independent apoptosis in lymphoma cells.

Chemical Structure

MMRi64
CAS#430458-66-5

Theoretical Analysis

MedKoo Cat#: 527530

Name: MMRi64

CAS#: 430458-66-5

Chemical Formula: C22H17Cl2N3O

Exact Mass: 409.0749

Molecular Weight: 410.30

Elemental Analysis: C, 64.40; H, 4.18; Cl, 17.28; N, 10.24; O, 3.90

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,350.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 4,350.00 2 Weeks
2g USD 6,950.00 2 Weeks
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Related CAS #
No Data
Synonym
MMRi64; MMRi-64; MMRi 64;
IUPAC/Chemical Name
7-[(2,3-Dichloro-phenyl)-(4-methyl-pyridin-2-ylamino)-methyl]-quinolin-8-ol
InChi Key
HQICAVDTVBACIN-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H17Cl2N3O/c1-13-9-11-25-18(12-13)27-21(15-5-2-6-17(23)19(15)24)16-8-7-14-4-3-10-26-20(14)22(16)28/h2-12,21,28H,1H3,(H,25,27)
SMILES Code
OC1=C2N=CC=CC2=CC=C1C(C3=CC=CC(Cl)=C3Cl)NC4=NC=CC(C)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 410.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wu W, Xu C, Ling X, Fan C, Buckley BP, Chernov MV, Ellis L, Li F, Muñoz IG, Wang X. Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells. Cell Death Dis. 2015 Dec 31;6:e2035. doi: 10.1038/cddis.2015.358. PubMed PMID: 26720344; PubMed Central PMCID: PMC4720891.