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MedKoo Cat#: 571469 | Name: Acaterin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Acaterin is an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT). It inhibits synthesis of cholesteryl ester in macrophage J774.

Chemical Structure

Acaterin
Acaterin
CAS#144398-20-9

Theoretical Analysis

MedKoo Cat#: 571469

Name: Acaterin

CAS#: 144398-20-9

Chemical Formula: C13H22O3

Exact Mass: 226.1569

Molecular Weight: 226.32

Elemental Analysis: C, 68.99; H, 9.80; O, 21.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Acaterin
IUPAC/Chemical Name
2(5H)-Furanone, 3-(1-hydroxyoctyl)-5-methyl-
InChi Key
YUMHJXLSSASJGN-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H22O3/c1-3-4-5-6-7-8-12(14)11-9-10(2)16-13(11)15/h9-10,12,14H,3-8H2,1-2H3
SMILES Code
O=C1OC(C)C=C1C(O)CCCCCCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 226.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Naganuma S, Sakai K, Hasumi K, Endo A. Acaterin, a novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Pseudomonas sp. A92. J Antibiot (Tokyo). 1992 Aug;45(8):1216-21. PubMed PMID: 1399841. 2: Nakano S, Sakane W, Oinaka H, Fujimoto Y. Biosynthesis of acaterin: mechanism of the reaction catalyzed by dehydroacaterin reductase. Bioorg Med Chem. 2006 Sep 15;14(18):6404-8. Epub 2006 Jun 9. PubMed PMID: 16765052. 3: Sekiyama Y, Fujimoto Y, Hasumi K, Endo A. Biosynthesis of acaterin: coupling of C(5) unit with octanoate. J Org Chem. 2001 Aug 24;66(17):5649-54. PubMed PMID: 11511235. 4: Hatano E, Hashidoko Y, Deora A, Fukushi Y, Tahara S. Isolation and structure elucidation of Peronosporomycetes hyphal branching-inducing factors produced by Pseudomonas jessenii EC-S101. Biosci Biotechnol Biochem. 2007 Jun;71(6):1601-5. PubMed PMID: 17587701.