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MedKoo Cat#: 571467 | Name: Clofentezine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clofentezine is an acaricide that primarily is used to target mites.

Chemical Structure

Clofentezine
Clofentezine
CAS#74115-24-5

Theoretical Analysis

MedKoo Cat#: 571467

Name: Clofentezine

CAS#: 74115-24-5

Chemical Formula: C14H8Cl2N4

Exact Mass: 302.0126

Molecular Weight: 303.15

Elemental Analysis: C, 55.47; H, 2.66; Cl, 23.39; N, 18.48

Price and Availability

Size Price Availability Quantity
250mg USD 450.00 2 Weeks
1g USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
Clofnetezine; Apollo; Panatac; Bisclofentazin; Bisclofentazine
IUPAC/Chemical Name
1,2,4,5-Tetrazine, 3,6-bis(2-chlorophenyl)-
InChi Key
UXADOQPNKNTIHB-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H8Cl2N4/c15-11-7-3-1-5-9(11)13-17-19-14(20-18-13)10-6-2-4-8-12(10)16/h1-8H
SMILES Code
ClC1=CC=CC=C1C2=NN=C(C3=CC=CC=C3Cl)N=N2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 303.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kang G, Cho S, Lee S, Kim TH. Crystal structure of 3,6-bis-(2-chloro-phen-yl)-1,2,4,5-tetra-zine: the acaricide clofentezine. Acta Crystallogr Sect E Struct Rep Online. 2014 Sep 30;70(Pt 10):o1135. doi: 10.1107/S1600536814021291. eCollection 2014 Oct 1. PubMed PMID: 25484714; PubMed Central PMCID: PMC4257200. 2: Demaeght P, Osborne EJ, Odman-Naresh J, Grbić M, Nauen R, Merzendorfer H, Clark RM, Van Leeuwen T. High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally diverse mite growth inhibitors clofentezine, hexythiazox and etoxazole in Tetranychus urticae. Insect Biochem Mol Biol. 2014 Aug;51:52-61. doi: 10.1016/j.ibmb.2014.05.004. Epub 2014 May 22. PubMed PMID: 24859419; PubMed Central PMCID: PMC4124130. 3: Tuzimski T. Determination of clofentezine in medical herb extracts by chromatographic methods combined with diode array scanning densitometry. J Sep Sci. 2010 Jul;33(13):1954-8. doi: 10.1002/jssc.201000177. PubMed PMID: 20506241. 4: Pree DJ, Bittner LA, Whitty KJ. Characterization of resistance to clofentezine in populations of European red mite from orchards in Ontario. Exp Appl Acarol. 2002;27(3):181-93. PubMed PMID: 12593584. 5: Li D, Tian J, Shen Z. Assessment of sublethal effects of clofentezine on life-table parameters in Hawthorn spider mite (Tetranychus viennensis). Exp Appl Acarol. 2006;38(4):255-73. PubMed PMID: 16612669. 6: Peng B, Zhang J, Lu R, Zhang S, Zhou W, Gao H. Dispersive micro-solid phase extraction based on self-assembling, ionic liquid-coated magnetic particles for the determination of clofentezine and chlorfenapyr in environmental water samples. Analyst. 2013 Nov 21;138(22):6834-43. doi: 10.1039/c3an00814b. PubMed PMID: 24060962. 7: Marcic D. The effects of clofentezine on life-table parameters in two-spotted spider mite Tetranychus urticae. Exp Appl Acarol. 2003;30(4):249-63. PubMed PMID: 14756391. 8: Sasaki K, Tatsuno T, Nakamura M, Imazawa T, Utsunomiya O, Kondo Y, Osada H, Takahata K, Toyoda M. [Method-performance studies of notified analytical method for clofentezine]. Shokuhin Eiseigaku Zasshi. 2001 Aug;42(4):278-82. Japanese. PubMed PMID: 11817146. 9: Barnes KA, Fussell RJ, Startin JR, Thorpe SA, Reynolds SL. Determination of the pesticides diflubenzuron and clofentezine in plums, strawberries and blackcurrant-based fruit drinks by high performance liquid chromatographic/atmospheric pressure chemical ionization-mass spectrometry. Rapid Commun Mass Spectrom. 1995;9(14):1441-5. PubMed PMID: 8534892. 10: Navickiene S, Ribeiro ML. Determination of fluquinconazole, pyrimethanil, and clofentezine residues in fruits by liquid chromatography with ultraviolet detection. J AOAC Int. 2004 Mar-Apr;87(2):435-8. PubMed PMID: 15164839. 11: Van Leeuwen T, Tirry L, Yamamoto A, Nauen R, Dermauw W. The economic importance of acaricides in the control of phytophagous mites and an update on recent acaricide mode of action research. Pestic Biochem Physiol. 2015 Jun;121:12-21. doi: 10.1016/j.pestbp.2014.12.009. Epub 2014 Dec 12. Review. PubMed PMID: 26047107. 12: Abraham CM, Braman SK, Oetting RD, Hinkle NC. Pesticide compatibility with natural enemies for pest management in greenhouse gerbera daisies. J Econ Entomol. 2013 Aug;106(4):1590-601. PubMed PMID: 24020270. 13: Li Y, Yang N, Wei X, Ling Y, Yang X, Wang Q. Evaluation of etoxazole against insects and acari in vegetables in China. J Insect Sci. 2014;14:104. doi: 10.1673/031.014.104. PubMed PMID: 25199415. 14: Yorulmaz-Salman S, Ay R. Determination of the inheritance, cross-resistance and detoxifying enzyme levels of a laboratory-selected, spiromesifen-resistant population of the predatory mite Neoseiulus californicus (Acari: Phytoseiidae). Pest Manag Sci. 2014 May;70(5):819-26. doi: 10.1002/ps.3623. Epub 2013 Aug 30. PubMed PMID: 23907738. 15: Tuzimski T, Rejczak T. Determination of pesticides in sunflower seeds by high-performance liquid chromatography coupled with a diode array detector. J AOAC Int. 2014 Jul-Aug;97(4):1012-20. PubMed PMID: 25145131. 16: Nauen R, Stumpf N, Elbert A, Zebitz CP, Kraus W. Acaricide toxicity and resistance in larvae of different strains of Tetranychus urticae and Panonychus ulmi (Acari: Tetranychidae). Pest Manag Sci. 2001 Mar;57(3):253-61. PubMed PMID: 11455655. 17: Riga M, Tsakireli D, Ilias A, Morou E, Myridakis A, Stephanou EG, Nauen R, Dermauw W, Van Leeuwen T, Paine M, Vontas J. Abamectin is metabolized by CYP392A16, a cytochrome P450 associated with high levels of acaricide resistance in Tetranychus urticae. Insect Biochem Mol Biol. 2014 Mar;46:43-53. doi: 10.1016/j.ibmb.2014.01.006. Epub 2014 Jan 23. PubMed PMID: 24463358. 18: Urbaneja A, Pascual-Ruiz S, Pina T, Abad-Moyano R, Vanaclocha P, Montón H, Dembilio O, Castañera P, Jacas JA. Efficacy of five selected acaricides against Tetranychus urticae (Acari: Tetranychidae) and their side effects on relevant natural enemies occurring in citrus orchards. Pest Manag Sci. 2008 Aug;64(8):834-42. doi: 10.1002/ps.1572. PubMed PMID: 18383196. 19: Hardman JM, Franklin JL, Beaulieu F, Bostanian NJ. Effects of acaricides, pyrethroids and predator distributions on populations of Tetranychus urticae in apple orchards. Exp Appl Acarol. 2007;43(4):235-53. Epub 2007 Nov 16. PubMed PMID: 18008172. 20: Tirello P, Pozzebon A, Cassanelli S, Van Leeuwen T, Duso C. Resistance to acaricides in Italian strains of Tetranychus urticae: toxicological and enzymatic assays. Exp Appl Acarol. 2012 May;57(1):53-64. doi: 10.1007/s10493-012-9536-y. Epub 2012 Mar 24. PubMed PMID: 22447041.

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