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MedKoo Cat#: 584190 | Name: BI-RJ 70

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BI-RJ 70 is a tritiated photoaffinity azido analog of nevirapine and can be used to study the binding of nevirapine to HIV-1 transcriptase through covalently labeled enzymes and amino acid residues.

Chemical Structure

BI-RJ 70
BI-RJ 70
CAS#132377-83-4

Theoretical Analysis

MedKoo Cat#: 584190

Name: BI-RJ 70

CAS#: 132377-83-4

Chemical Formula: C15H14N6O

Exact Mass: 294.1229

Molecular Weight: 294.32

Elemental Analysis: C, 61.21; H, 4.79; N, 28.55; O, 5.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BI-RJ 70; BI-RJ-70; BI RJ 70; BIRJ70
IUPAC/Chemical Name
5H-Pyrido(2,3-b)(1,5)benzodiapin-5-one, 9-azido-11-ethyl-6,11-dihydro-6-methyl-
InChi Key
APHMGGWRVNQQAC-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H14N6O/c1-3-21-13-9-10(18-19-16)6-7-12(13)20(2)15(22)11-5-4-8-17-14(11)21/h4-9H,3H2,1-2H3
SMILES Code
O=C1C2=CC=CN=C2N(CC)C3=CC(N=[N+]=[N-])=CC=C3N1C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 294.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Palladino DE, Hopkins JL, Ingraham RH, Warren TC, Kapadia SR, Van Moffaert GJ, Grob PM, Stevenson JM, Cohen KA. High-performance liquid chromatography and photoaffinity crosslinking to explore the binding environment of nevirapine to reverse transcriptase of human immunodeficiency virus. J Chromatogr A. 1994 Jul 29;676(1):99-112. PubMed PMID: 7522840. 2: Cohen KA, Hopkins J, Ingraham RH, Pargellis C, Wu JC, Palladino DE, Kinkade P, Warren TC, Rogers S, Adams J, et al. Characterization of the binding site for nevirapine (BI-RG-587), a nonnucleoside inhibitor of human immunodeficiency virus type-1 reverse transcriptase. J Biol Chem. 1991 Aug 5;266(22):14670-4. PubMed PMID: 1713587.