SLM6 | CAS#22242-91-7 | CDK9 inhibitor

MedKoo Cat#: 561772 | Name: SLM6

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SLM6 is an inhibitor of cyclin-dependent kinase-9 (CDK9). It exhibits potent anti-multiple myeloma activity.

Chemical Structure

SLM6

CAS#22242-91-7

Theoretical Analysis

MedKoo Cat#: 561772

Name: SLM6

CAS#: 22242-91-7

Chemical Formula: C12H17N7O4

Exact Mass: 323.1342

Molecular Weight: 323.31

Elemental Analysis: C, 44.58; H, 5.30; N, 30.33; O, 19.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SLM6; SLM-6; SLM 6; Sangivamycin-Like Molecule 6; NSC-107517; NSC 107517; NSC107517;

IUPAC/Chemical Name

4-Amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbohydrazonamide

InChi Key

WAMOLHIDNBDQSK-JTFADIMSSA-N

InChi Code

InChI=1S/C12H17N7O4/c13-9(18-15)4-1-19(11-6(4)10(14)16-3-17-11)12-8(22)7(21)5(2-20)23-12/h1,3,5,7-8,12,20-22H,2,15H2,(H2,13,18)(H2,14,16,17)/t5-,7-,8-,12-/m1/s1

SMILES Code

N/C(C1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C3=NC=NC(N)=C31)=N\N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 323.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Dolloff NG, Allen JE, Dicker DT, Aqui N, Vogl D, Malysz J, Talamo G, El-Deiry WS. Sangivamycin-like molecule 6 exhibits potent anti-multiple myeloma activity through inhibition of cyclin-dependent kinase-9. Mol Cancer Ther. 2012 Nov;11(11):2321-30. doi: 10.1158/1535-7163.MCT-12-0578. Epub 2012 Sep 10. PubMed PMID: 22964485; PubMed Central PMCID: PMC3502072. 2: Araki Y, Kawasaki Y, Sasanuma H, Tye BK, Sugino A. Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability. Genes Cells. 2003 May;8(5):465-80. PubMed PMID: 12694535.