MedKoo Cat#: 527484 | Name: LY3031207
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY3031207, also known as mPGES-1 Inhibitor-1 is a novel selective microsomal prostaglandin E synthase-1 (mPGES-1) Inhibitor.

Chemical Structure

LY3031207
LY3031207
CAS#1381846-21-4

Theoretical Analysis

MedKoo Cat#: 527484

Name: LY3031207

CAS#: 1381846-21-4

Chemical Formula: C16H19ClN4O2

Exact Mass: 334.1197

Molecular Weight: 334.80

Elemental Analysis: C, 57.40; H, 5.72; Cl, 10.59; N, 16.73; O, 9.56

Price and Availability

Size Price Availability Quantity
1mg USD 225.00 2 Weeks
5mg USD 495.00 2 Weeks
10mg USD 810.00 2 Weeks
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Related CAS #
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Synonym
mPGES-1 Inhibitor-1; LY-3031207; LY3031207; LY 3031207;
IUPAC/Chemical Name
2-Chloro-5-[(2,2-dimethyl-propionylamino)-methyl]-N-(1H-imidazol-2-yl)-benzamide
InChi Key
MBAHGUNQNAJTLD-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H19ClN4O2/c1-16(2,3)14(23)20-9-10-4-5-12(17)11(8-10)13(22)21-15-18-6-7-19-15/h4-8H,9H2,1-3H3,(H,20,23)(H2,18,19,21,22)
SMILES Code
O=C(NC1=NC=CN1)C2=CC(CNC(C(C)(C)C)=O)=CC=C2Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 334.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Avendaño MS, Martínez-Revelles S, Aguado A, Simões MR, González-Amor M, Palacios R, Guillem-Llobat P, Vassallo DV, Vila L, García-Puig J, Beltrán LM, Alonso MJ, Cachofeiro MV, Salaices M, Briones AM. Role of COX-2-derived PGE2 on vascular stiffness and function in hypertension. Br J Pharmacol. 2016 May;173(9):1541-55. doi: 10.1111/bph.13457. Epub 2016 Mar 21. PubMed PMID: 26856544; PubMed Central PMCID: PMC4831311. 2: Bylund J, Bueters T. Presystemic metabolism of AZ'0908, a novel mPGES-1 inhibitor: an in vitro and in vivo cross-species comparison. J Pharm Sci. 2013 Mar;102(3):1106-15. doi: 10.1002/jps.23443. Epub 2013 Jan 11. PubMed PMID: 23316000.