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MedKoo Cat#: 527483 | Name: PPZ1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PPZ1 is a novel activator of DAG-activated TRPC3/TRPC6/TRPC7 channels.

Chemical Structure

PPZ1
PPZ1
CAS#915893-66-2

Theoretical Analysis

MedKoo Cat#: 527483

Name: PPZ1

CAS#: 915893-66-2

Chemical Formula: C18H18ClFN2O

Exact Mass: 332.1092

Molecular Weight: 332.80

Elemental Analysis: C, 64.96; H, 5.45; Cl, 10.65; F, 5.71; N, 8.42; O, 4.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PPZ1; PPZ 1; PPZ-1
IUPAC/Chemical Name
[4-(5-Chloro-2-methylphenyl)piperazin-1-yl](3-fluorophenyl)methanone
InChi Key
NSJDIIBHIXTDNW-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H18ClFN2O/c1-13-5-6-15(19)12-17(13)21-7-9-22(10-8-21)18(23)14-3-2-4-16(20)11-14/h2-6,11-12H,7-10H2,1H3
SMILES Code
O=C(N1CCN(C2=CC(Cl)=CC=C2C)CC1)C3=CC=CC(F)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 332.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Molero C, Casado C, Ariño J. The inhibitory mechanism of Hal3 on the yeast Ppz1 phosphatase: A mutagenesis analysis. Sci Rep. 2017 Aug 18;7(1):8819. doi: 10.1038/s41598-017-09360-5. PubMed PMID: 28821821; PubMed Central PMCID: PMC5562863. 2: Chen E, Choy MS, Petrényi K, Kónya Z, Erdődi F, Dombrádi V, Peti W, Page R. Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans. MBio. 2016 Aug 30;7(4). pii: e00872-16. doi: 10.1128/mBio.00872-16. PubMed PMID: 27578752; PubMed Central PMCID: PMC4999541. 3: Sawamura S, Hatano M, Takada Y, Hino K, Kawamura T, Tanikawa J, Nakagawa H, Hase H, Nakao A, Hirano M, Rotrattanadumrong R, Kiyonaka S, Mori MX, Nishida M, Hu Y, Inoue R, Nagata R, Mori Y. Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds. Mol Pharmacol. 2016 Mar;89(3):348-63. doi: 10.1124/mol.115.102863. Epub 2016 Jan 5. PubMed PMID: 26733543. 4: Abrie JA, Molero C, Ariño J, Strauss E. Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3. Sci Rep. 2015 Oct 30;5:15774. doi: 10.1038/srep15774. PubMed PMID: 26514574; PubMed Central PMCID: PMC4626798. 5: Fasano R, Gonzalez N, Tosco A, Dal Piaz F, Docimo T, Serrano R, Grillo S, Leone A, Inzé D. Role of Arabidopsis UV RESISTANCE LOCUS 8 in plant growth reduction under osmotic stress and low levels of UV-B. Mol Plant. 2014 May;7(5):773-91. doi: 10.1093/mp/ssu002. Epub 2014 Jan 10. PubMed PMID: 24413416. 6: Molero C, Petrényi K, González A, Carmona M, Gelis S, Abrie JA, Strauss E, Ramos J, Dombradi V, Hidalgo E, Ariño J. The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities. Mol Microbiol. 2013 Oct;90(2):367-82. doi: 10.1111/mmi.12370. Epub 2013 Sep 10. PubMed PMID: 23962284. 7: González A, Casado C, Petrezsélyová S, Ruiz A, Ariño J. Molecular analysis of a conditional hal3 vhs3 yeast mutant links potassium homeostasis with flocculation and invasiveness. Fungal Genet Biol. 2013 Apr;53:1-9. doi: 10.1016/j.fgb.2013.02.007. Epub 2013 Feb 27. PubMed PMID: 23454581. 8: Feller A, Georis I, Tate JJ, Cooper TG, Dubois E. Alterations in the Ure2 αCap domain elicit different GATA factor responses to rapamycin treatment and nitrogen limitation. J Biol Chem. 2013 Jan 18;288(3):1841-55. doi: 10.1074/jbc.M112.385054. Epub 2012 Nov 26. PubMed PMID: 23184930; PubMed Central PMCID: PMC3548494. 9: Leiter É, González A, Erdei É, Casado C, Kovács L, Ádám C, Oláh J, Miskei M, Molnar M, Farkas I, Hamari Z, Ariño J, Pócsi I, Dombrádi V. Protein phosphatase Z modulates oxidative stress response in fungi. Fungal Genet Biol. 2012 Sep;49(9):708-16. doi: 10.1016/j.fgb.2012.06.010. Epub 2012 Jun 30. PubMed PMID: 22750657. 10: Adám C, Erdei E, Casado C, Kovács L, González A, Majoros L, Petrényi K, Bagossi P, Farkas I, Molnar M, Pócsi I, Ariño J, Dombrádi V. Protein phosphatase CaPpz1 is involved in cation homeostasis, cell wall integrity and virulence of Candida albicans. Microbiology. 2012 May;158(Pt 5):1258-67. doi: 10.1099/mic.0.057075-0. Epub 2012 Feb 16. PubMed PMID: 22343349. 11: Minhas A, Sharma A, Kaur H, Rawal Y, Ganesan K, Mondal AK. Conserved Ser/Arg-rich motif in PPZ orthologs from fungi is important for its role in cation tolerance. J Biol Chem. 2012 Mar 2;287(10):7301-12. doi: 10.1074/jbc.M111.299438. Epub 2012 Jan 9. PubMed PMID: 22232558; PubMed Central PMCID: PMC3293525. 12: Abrie JA, González A, Strauss E, Ariño J. Functional mapping of the disparate activities of the yeast moonlighting protein Hal3. Biochem J. 2012 Mar 1;442(2):357-68. doi: 10.1042/BJ20111466. PubMed PMID: 22124281. 13: Ivanov MS, Radchenko EA, Mironova LN. [The protein complex Ppz1p/Hal3p and nonsense suppression efficiency in the yeast Saccharomyces cerevisiae]. Mol Biol (Mosk). 2010 Nov-Dec;44(6):1018-26. Russian. PubMed PMID: 21290823. 14: Hirasaki M, Horiguchi M, Numamoto M, Sugiyama M, Kaneko Y, Nogi Y, Harashima S. Saccharomyces cerevisiae protein phosphatase Ppz1 and protein kinases Sat4 and Hal5 are involved in the control of subcellular localization of Gln3 by likely regulating its phosphorylation state. J Biosci Bioeng. 2011 Mar;111(3):249-54. doi: 10.1016/j.jbiosc.2010.11.013. Epub 2011 Jan 14. PubMed PMID: 21237705. 15: Merchan S, Pedelini L, Hueso G, Calzada A, Serrano R, Yenush L. Genetic alterations leading to increases in internal potassium concentrations are detrimental for DNA integrity in Saccharomyces cerevisiae. Genes Cells. 2011 Feb;16(2):152-65. doi: 10.1111/j.1365-2443.2010.01472.x. Epub 2010 Dec 9. PubMed PMID: 21143561. 16: Ruiz A, González A, Muñoz I, Serrano R, Abrie JA, Strauss E, Ariño J. Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol. 2009 Dec;5(12):920-8. doi: 10.1038/nchembio.243. Epub 2009 Nov 1. PubMed PMID: 19915539. 17: Rogoza TM, Viktorovskaia OV, Rodionova SA, Ivanov MS, Volkov KV, Mironova LN. [Search for the genes critical for propagation of the prion-like antisuppressor determinant [ISP+] in yeast using insertion library]. Mol Biol (Mosk). 2009 May-Jun;43(3):392-9. Russian. PubMed PMID: 19548524. 18: Ivanov MS, Aksenova AIu, Burdaeva IaV, Radchenko EA, Mironova LN. [Overexpression of gene PPZ1 in the yeast Saccharomyces cerevisiae affects the efficiency of nonsense suppression]. Genetika. 2008 Feb;44(2):177-84. Russian. PubMed PMID: 18619035. 19: Fulgenzi FR, Peralta ML, Mangano S, Danna CH, Vallejo AJ, Puigdomenech P, Santa-María GE. The ionic environment controls the contribution of the barley HvHAK1 transporter to potassium acquisition. Plant Physiol. 2008 May;147(1):252-62. doi: 10.1104/pp.107.114546. Epub 2008 Mar 21. PubMed PMID: 18359846; PubMed Central PMCID: PMC2330294. 20: Aksenova A, Muñoz I, Volkov K, Ariño J, Mironova L. The HAL3-PPZ1 dependent regulation of nonsense suppression efficiency in yeast and its influence on manifestation of the yeast prion-like determinant [ISP(+)]. Genes Cells. 2007 Apr;12(4):435-45. PubMed PMID: 17397392.