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MedKoo Cat#: 527482 | Name: PPZ2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PPZ2 is a novel activator of DAG-activated TRPC3/TRPC6/TRPC7 channels.

Chemical Structure

PPZ2
PPZ2
CAS#896203-18-2

Theoretical Analysis

MedKoo Cat#: 527482

Name: PPZ2

CAS#: 896203-18-2

Chemical Formula: C22H29N3O2

Exact Mass: 367.2260

Molecular Weight: 367.49

Elemental Analysis: C, 71.90; H, 7.95; N, 11.43; O, 8.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PPZ 2; PPZ-2; PPZ2
IUPAC/Chemical Name
2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-N-(2-ethoxyphenyl)acetamide
InChi Key
FVNDSDZIAJJKNY-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H29N3O2/c1-4-27-21-11-6-5-9-19(21)23-22(26)16-24-12-14-25(15-13-24)20-10-7-8-17(2)18(20)3/h5-11H,4,12-16H2,1-3H3,(H,23,26)
SMILES Code
O=C(NC1=CC=CC=C1OCC)CN2CCN(C3=CC=CC(C)=C3C)CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 367.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sawamura S, Hatano M, Takada Y, Hino K, Kawamura T, Tanikawa J, Nakagawa H, Hase H, Nakao A, Hirano M, Rotrattanadumrong R, Kiyonaka S, Mori MX, Nishida M, Hu Y, Inoue R, Nagata R, Mori Y. Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds. Mol Pharmacol. 2016 Mar;89(3):348-63. doi: 10.1124/mol.115.102863. Epub 2016 Jan 5. PubMed PMID: 26733543. 2: Cheng YL, Chen RH. Assembly and quality control of the protein phosphatase 1 holoenzyme involves the Cdc48-Shp1 chaperone. J Cell Sci. 2015 Mar 15;128(6):1180-92. doi: 10.1242/jcs.165159. Epub 2015 Jan 22. PubMed PMID: 25616896. 3: Merchan S, Pedelini L, Hueso G, Calzada A, Serrano R, Yenush L. Genetic alterations leading to increases in internal potassium concentrations are detrimental for DNA integrity in Saccharomyces cerevisiae. Genes Cells. 2011 Feb;16(2):152-65. doi: 10.1111/j.1365-2443.2010.01472.x. Epub 2010 Dec 9. PubMed PMID: 21143561. 4: Bozaquel-Morais BL, Madeira JB, Maya-Monteiro CM, Masuda CA, Montero-Lomeli M. A new fluorescence-based method identifies protein phosphatases regulating lipid droplet metabolism. PLoS One. 2010 Oct 28;5(10):e13692. doi: 10.1371/journal.pone.0013692. PubMed PMID: 21060891; PubMed Central PMCID: PMC2965658. 5: Ruiz A, del Carmen Ruiz M, Sánchez-Garrido MA, Ariño J, Ramos J. The Ppz protein phosphatases regulate Trk-independent potassium influx in yeast. FEBS Lett. 2004 Dec 3;578(1-2):58-62. PubMed PMID: 15581616. 6: Ruiz A, Muñoz I, Serrano R, González A, Simón E, Ariño J. Functional characterization of the Saccharomyces cerevisiae VHS3 gene: a regulatory subunit of the Ppz1 protein phosphatase with novel, phosphatase-unrelated functions. J Biol Chem. 2004 Aug 13;279(33):34421-30. Epub 2004 Jun 10. PubMed PMID: 15192104. 7: Ruiz A, Yenush L, Ariño J. Regulation of ENA1 Na(+)-ATPase gene expression by the Ppz1 protein phosphatase is mediated by the calcineurin pathway. Eukaryot Cell. 2003 Oct;2(5):937-48. PubMed PMID: 14555476; PubMed Central PMCID: PMC219373. 8: Sakumoto N, Matsuoka I, Mukai Y, Ogawa N, Kaneko Y, Harashima S. A series of double disruptants for protein phosphatase genes in Saccharomyces cerevisiae and their phenotypic analysis. Yeast. 2002 May;19(7):587-99. PubMed PMID: 11967829. 9: Yenush L, Mulet JM, Ariño J, Serrano R. The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. EMBO J. 2002 Mar 1;21(5):920-9. PubMed PMID: 11867520; PubMed Central PMCID: PMC125902. 10: de Nadal E, Fadden RP, Ruiz A, Haystead T, Ariño J. A role for the Ppz Ser/Thr protein phosphatases in the regulation of translation elongation factor 1Balpha. J Biol Chem. 2001 May 4;276(18):14829-34. Epub 2001 Feb 5. PubMed PMID: 11278758. 11: Vissi E, Clotet J, de Nadal E, Barceló A, Bakó E, Gergely P, Dombrádi V, Ariño J. Functional analysis of the Neurospora crassa PZL-1 protein phosphatase by expression in budding and fission yeast. Yeast. 2001 Jan 30;18(2):115-24. PubMed PMID: 11169754. 12: Venturi GM, Bloecher A, Williams-Hart T, Tatchell K. Genetic interactions between GLC7, PPZ1 and PPZ2 in saccharomyces cerevisiae. Genetics. 2000 May;155(1):69-83. PubMed PMID: 10790385; PubMed Central PMCID: PMC1461071. 13: Balcells L, Gómez N, Casamayor A, Clotet J, Ariño J. Regulation of salt tolerance in fission yeast by a protein-phosphatase-Z-like Ser/Thr protein phosphatase. Eur J Biochem. 1997 Dec 1;250(2):476-83. PubMed PMID: 9428701. 14: Posas F, Camps M, Ariño J. The PPZ protein phosphatases are important determinants of salt tolerance in yeast cells. J Biol Chem. 1995 Jun 2;270(22):13036-41. PubMed PMID: 7768897. 15: Vincent A, Newnam G, Liebman SW. The yeast translational allosuppressor, SAL6: a new member of the PP1-like phosphatase family with a long serine-rich N-terminal extension. Genetics. 1994 Nov;138(3):597-608. PubMed PMID: 7851758; PubMed Central PMCID: PMC1206211. 16: Chen MX, Chen YH, Cohen PT. PPQ, a novel protein phosphatase containing a Ser + Asn-rich amino-terminal domain, is involved in the regulation of protein synthesis. Eur J Biochem. 1993 Dec 1;218(2):689-99. Erratum in: Eur J Biochem 1994 May 1;221(3):1133. PubMed PMID: 8269960. 17: Lee KS, Hines LK, Levin DE. A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway. Mol Cell Biol. 1993 Sep;13(9):5843-53. PubMed PMID: 8395014; PubMed Central PMCID: PMC360330. 18: Hughes V, Müller A, Stark MJ, Cohen PT. Both isoforms of protein phosphatase Z are essential for the maintenance of cell size and integrity in Saccharomyces cerevisiae in response to osmotic stress. Eur J Biochem. 1993 Aug 15;216(1):269-79. Erratum in: Eur J Biochem 1993 Sep 15;216(3):881. PubMed PMID: 8396031. 19: Posas F, Casamayor A, Ariño J. The PPZ protein phosphatases are involved in the maintenance of osmotic stability of yeast cells. FEBS Lett. 1993 Mar 8;318(3):282-6. PubMed PMID: 8382634. 20: Da Cruz e Silva EF, Hughes V, McDonald P, Stark MJ, Cohen PT. Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes. Biochim Biophys Acta. 1991 Jun 13;1089(2):269-72. PubMed PMID: 1647215.