MedKoo Cat#: 571453 | Name: Quinuronium Sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Quinuronium sulfate is a drug that has been used to treat Babesia divergens infections in calves. It did not prevent treated animals from being disease carriers. It also may cause hepatic centrilobular fatty degeneration, but no depletion of hepatic glutathione (GSH).

Chemical Structure

Quinuronium Sulfate
Quinuronium Sulfate
CAS#135-14-8

Theoretical Analysis

MedKoo Cat#: 571453

Name: Quinuronium Sulfate

CAS#: 135-14-8

Chemical Formula: C23H26N4O9S2

Exact Mass:

Molecular Weight: 566.60

Elemental Analysis: C, 48.76; H, 4.63; N, 9.89; O, 25.41; S, 11.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Quinuronium sulfate; Acaprin; Pirevan; Zothelone
IUPAC/Chemical Name
1,1'-Dimethyl-6,6'-ureylenediquinolinium dimethyl bis(sulphate)
InChi Key
BOMUADPKDXMXIH-UHFFFAOYSA-M
InChi Code
InChI=1S/C21H19N4O.2CH4O4S/c1-24-11-3-5-15-13-17(7-9-19(15)24)22-21(26)23-18-8-10-20-16(14-18)6-4-12-25(20)2;2*1-5-6(2,3)4/h3-14H,1-2H3,(H-,22,23,26);2*1H3,(H,2,3,4)/q+1;;/p-1
SMILES Code
O=C(NC1=CC2=CC=C[N+](C)=C2C=C1)NC3=CC4=CC=C[N+](C)=C4C=C3.O=S(OC)([O-])=O.O=S(OC)([O-])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 566.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mitema ES, Maribei JM. Quinuronium induced hepatotoxicity in rats. Toxicol Lett. 1985 Jan;24(1):53-8. PubMed PMID: 3975929. 2: Mitema ES. Comparative studies of the effects of quinuronium sulfate and diminazene diaceturate in sheep. Vet Hum Toxicol. 1985 Dec;27(6):539-42. PubMed PMID: 4082473. 3: Mitema ES. Quinuronium levels in ovine plasma as determined by an in vitro/in vivo system with Babesia rodhaini. Arch Int Pharmacodyn Ther. 1985 Jul;276(1):12-6. PubMed PMID: 4051633. 4: Mitema ES, Nafstad I, Frøslie A. Effects of quinuronium sulfate pre-exposure on hepatic excretion of sulfobromophthalein (BSP) as measured by isolated perfused rat liver. Acta Pharmacol Toxicol (Copenh). 1983 Jul;53(1):44-8. PubMed PMID: 6613606. 5: Brockelman CR, Tan-ariya P. Development of an in vitro microtest to assess drug susceptibility of Babesia bovis and Babesia bigemina. J Parasitol. 1991 Dec;77(6):994-7. PubMed PMID: 1779305. 6: Purnell RE, Lewis D, Young ER. Quinuronium sulphate for the treatment of Babesia divergens infections of splenectomised calves. Vet Rec. 1981 Jun 20;108(25):538-9. PubMed PMID: 7269188. 7: Callow LL, McGregor W. Quinuronium sulphate poisoning of cattle. Vet Rec. 1967 Aug 12;81(7):175-6. PubMed PMID: 6050339. 8: Eyre P. Quinuronium sulphate poisoning. Vet Rec. 1966 Dec 24;79(26):862. PubMed PMID: 6009189. 9: Eyre P. Some pharmacodynamic effects of the babesicidal agents quinuronium and amicarbalide. J Pharm Pharmacol. 1967 Aug;19(8):509-19. PubMed PMID: 4382438. 10: Eyre P. Release of tissue histamine by the babesicidal agents quinuronium and amicarbalide. J Pharm Pharmacol. 1966 Jan;18(1):33-7. PubMed PMID: 4380701. 11: Callow LL, McGregor W. Vaccination against Babesia argentina infection in cattle during chemoprophylaxis with a quinuronium compound. Aust Vet J. 1969 Sep;45(9):408-10. PubMed PMID: 5389523. 12: Eyre P. The effects in sheep of quinuronium and amicarbalice and the influence of atropine pyridine 2-aldoxime methiodide (2-PAM). Adrenaline and mepyramine. Vet Rec. 1966 Apr 30;78(18):627-9. PubMed PMID: 4380961. 13: Mitema ES, Nafstad I, Maribei JM. Acute toxicity studies with quinuronium sulfate in laboratory animals and sheep. Toxicol Lett. 1984 Jan;20(1):69-74. PubMed PMID: 6695398. 14: Löhr FK, Otieno PS, Gacanga W. Therapy trial using betamethasone in addition to specific treatment with a diamidine and quinuronium derivate in cattle experimentally infected with Babesia bigemina. Bull Anim Health Prod Afr. 1976 Jun;24(2):199-205. PubMed PMID: 16300142. 15: Eyre P. Effects of quinuronium methylsulphate on voluntary muscle. Br J Pharmacol Chemother. 1968 Mar;32(3):624-34. PubMed PMID: 5641953; PubMed Central PMCID: PMC1570312. 16: Eyre P. The anticholinesterase activity of the babesicidal agents quinuronium and amicarbalide and the influence of pyridine 2-aldoxime methiodide. Res Vet Sci. 1966 Apr;7(2):161-7. PubMed PMID: 4959552.