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MedKoo Cat#: 527458 | Name: CU-3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CU-3 is a novel potent and selective diacylglycerol kinase alpha (DGKalpha) inhibitor, attenuating cancer cell proliferation and simultaneously enhancing immune responses including anti-cancer immunity.

Chemical Structure

CU-3
CU-3
CAS#861123-84-4

Theoretical Analysis

MedKoo Cat#: 527458

Name: CU-3

CAS#: 861123-84-4

Chemical Formula: C16H12N2O4S3

Exact Mass: 391.9959

Molecular Weight: 392.46

Elemental Analysis: C, 48.97; H, 3.08; N, 7.14; O, 16.31; S, 24.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CU-3; CU 3; CU3
IUPAC/Chemical Name
5-(3-(2-Furyl)prop-2-enylidene)-3-[(phenylsulfonyl)amino]-2-thioxo-1,3-thiazolidin-4-one
InChi Key
YIUMXULORVBWLL-SPGDJUBISA-N
InChi Code
InChI=1S/C16H12N2O4S3/c19-15-14(10-4-6-12-7-5-11-22-12)24-16(23)18(15)17-25(20,21)13-8-2-1-3-9-13/h1-11,17H/b6-4+,14-10-
SMILES Code
O=C1N(NS(=O)(C2=CC=CC=C2)=O)C(S/C1=C\C=C\C3=CC=CO3)=S
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 392.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Phys Rev Lett. 2017 Nov 24;119(21):217001. doi: 10.1103/PhysRevLett.119.217001. Epub 2017 Nov 20. PubMed PMID: 29219391. 5: Meite F, Alvarez-Zaldívar P, Crochet A, Wiegert C, Payraudeau S, Imfeld G. Impact of rainfall patterns and frequency on the export of pesticides and heavy-metals from agricultural soils. Sci Total Environ. 2018 Mar;616-617:500-509. doi: 10.1016/j.scitotenv.2017.10.297. Epub 2017 Nov 9. PubMed PMID: 29127804. 6: Pandey P, Kharediya B, Elrez B, Sutter JP, Bhargavi G, Rajasekharan MV, Sunkari SS. Ligand directed structural diversity and magnetism in copper(ii)-azido assemblies with isomeric aminopyridines: synthesis, structure, magnetism and theoretical studies. Dalton Trans. 2017 Nov 21;46(45):15908-15918. doi: 10.1039/c7dt03115g. PubMed PMID: 29119181. 7: Belyaev A, Eskelinen T, Dau TM, Ershova YY, Tunik SP, Melnikov AS, Hirva P, Koshevoy IO. Cyanide-Assembled d(10) Coordination Polymers and Cycles: Excited State Metallophilic Modulation of Solid-State Luminescence. Chemistry. 2017 Nov 8. doi: 10.1002/chem.201704642. [Epub ahead of print] PubMed PMID: 29115036. 8: Encina-Montoya F, Vega-Aguayo R, Díaz O, Esse C, Nimptsch J, Muñoz-Pedreros A. Mazzaella laminarioides and Sarcothalia crispata as possible bioindicators of heavy metal contamination in the marine coastal zone of Chile. Environ Monit Assess. 2017 Oct 26;189(11):584. doi: 10.1007/s10661-017-6297-4. PubMed PMID: 29075883. 9: Chainani A, Sicot M, Fagot-Revurat Y, Vasseur G, Granet J, Kierren B, Moreau L, Oura M, Yamamoto A, Tokura Y, Malterre D. Evidence for Weakly Correlated Oxygen Holes in the Highest-T_{c} Cuprate Superconductor HgBa_{2}Ca_{2}Cu_{3}O_{8+δ}. Phys Rev Lett. 2017 Aug 4;119(5):057001. doi: 10.1103/PhysRevLett.119.057001. Epub 2017 Jul 31. PubMed PMID: 28949729. 10: Caplan Y, Orgad D. Dimensional Crossover of Charge-Density Wave Correlations in the Cuprates. Phys Rev Lett. 2017 Sep 8;119(10):107002. doi: 10.1103/PhysRevLett.119.107002. Epub 2017 Sep 8. PubMed PMID: 28949186. 11: Bakircioglu D, Topraksever N, Kurtulus YB. Determination of Several Element Levels in Hardaliye Beverages Using Flame Atomic Absorption Spectrometry After Ultrasound-Probe Extraction. J AOAC Int. 2017 Sep 1;100(5):1531-1538. doi: 10.5740/jaoacint.17-0117. PubMed PMID: 28917262. 12: Li F, Qiu Z, Zhang J, Liu C, Cai Y, Xiao M. Spatial Distribution and Fuzzy Health Risk Assessment of Trace Elements in Surface Water from Honghu Lake. Int J Environ Res Public Health. 2017 Sep 4;14(9). pii: E1011. doi: 10.3390/ijerph14091011. PubMed PMID: 28869576; PubMed Central PMCID: PMC5615548. 13: Hazra S, Martins NMR, Kuznetsov ML, Guedes da Silva MFC, Pombeiro AJL. Flexibility and lability of a phenyl ligand in hetero-organometallic 3d metal-Sn(iv) compounds and their catalytic activity in Baeyer-Villiger oxidation of cyclohexanone. Dalton Trans. 2017 Oct 10;46(39):13364-13375. doi: 10.1039/c7dt02534c. PubMed PMID: 28829081. 14: Marangoni LFB, Marques JA, Duarte GAS, Pereira CM, Calderon EN, Castro CBE, Bianchini A. Copper effects on biomarkers associated with photosynthesis, oxidative status and calcification in the Brazilian coral Mussismilia harttii (Scleractinia, Mussidae). Mar Environ Res. 2017 Sep;130:248-257. doi: 10.1016/j.marenvres.2017.08.002. Epub 2017 Aug 10. PubMed PMID: 28823595. 15: Tian P, Liu D, Li K, Yang T, Wang J, Liu Y, Zhang S. Porous metal-organic framework Cu(3)(BTC)(2) as catalyst used in air-cathode for high performance of microbial fuel cell. Bioresour Technol. 2017 Nov;244(Pt 1):206-212. doi: 10.1016/j.biortech.2017.07.034. Epub 2017 Jul 8. PubMed PMID: 28779673. 16: Dolyniuk JA, Kovnir K. 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