Synonym
Phenaglycodol; Acalmid; Atadiol; Felixin; Puasital; Sedapsin; Sinforil; NSC 169451; NSC-169451; NSC169451
IUPAC/Chemical Name
2,3-Butanediol, 2-(4-chlorophenyl)-3-methyl- (9CI)
InChi Key
HTYIXCKSEQQCJO-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H15ClO2/c1-10(2,13)11(3,14)8-4-6-9(12)7-5-8/h4-7,13-14H,1-3H3
SMILES Code
CC(O)(C1=CC=C(Cl)C=C1)C(O)(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Phenaglycodol is a tranquilizing agent.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
214.69
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Rickels K, Csanalosi I, Gratch M, Gingrich RL Jr, Kelly EA, Mirman MJ. Phenaglycodol in anxiety: a controlled study. Curr Ther Res Clin Exp. 1975 Jan;17(1):23-31. PMID: 806427.
3: Brauzer B, Goldstein BJ. Placebo-controlled evaluation of phenaglycodol in anxious, depressed outpatients. J Clin Pharmacol New Drugs. 1972 Jul;12(7):280-5. doi: 10.1002/j.1552-4604.1972.tb00056.x. PMID: 4557536.
4: Di Maggio G, Ciaceri G. Andamento dell'idrolisi enzimatica della procaina per effetto del pretrattamento con carisoprodol, mebutamato o fenaglicodol [Proceeding of enzymatic hydrolysis of the procaine by the effect of pre- treatment with carisoprodol, mebutamate and phenaglycodol]. Omnia Med Ther. 1970 Jul-Sep;48(3):414-20. Italian. PMID: 5513566.
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6: Wallace JE. Determination of phenaglycodol in biologic specimens by ultraviolet spectrophotometry. J Pharm Sci. 1968 Mar;57(3):426-9. doi: 10.1002/jps.2600570311. PMID: 5655580.
7: MURPHY HW. PINACOL REARRANGEMENT OF PHENAGLYCODOL. I. CHARACTERIZATION OF PRODUCTS PRODUCED. J Pharm Sci. 1964 Mar;53:298-301. doi: 10.1002/jps.2600530311. PMID: 14185017.
8: KATO R, CHIESARA E. Increase of pentobarbitone metabolism induced in rats pretreated with some centrally acting compounds. Br J Pharmacol Chemother. 1962 Feb;18(1):29-38. doi: 10.1111/j.1476-5381.1962.tb01147.x. PMID: 14454287; PMCID: PMC1482168.
9: KATO R, CHIESARA E, FRONTINO G. Induced increase of meprobamate metabolism in rats pretreated with phenobarbital or phenaglycodol in relation to age. Experientia. 1961 Nov 15;17:520-1. doi: 10.1007/BF02158634. PMID: 14454280.
10: KATO R, FRONTINO G, VASSANELLI P. Comparative study of inhibitory action of ethionine, 8-azaguanine, 6-mercaptopurine and x- or gamma-irradiation on the induction of the hepatic drug-metabolizing enzymes by phenobarbital or phenaglycodol. Jpn J Pharmacol. 1961 Sep;11:25-30. doi: 10.1254/jjp.11.25. PMID: 14454288.
11: KATO R. Modifications of the toxicity of strychnine and octomethylpyrophosphoramide (OMPA) induced by pretreatment with phenaglycodol and thiopental. Arzneimittelforschung. 1961 Aug;11:797-8. PMID: 14454292.
12: FRIEND DG. Current concepts in the therapy. Tranquilizers. III. Meprobamate, phenaglycodol and chlordiazepoxide. N Engl J Med. 1961 Apr 27;264:870-3. doi: 10.1056/NEJM196104272641710. PMID: 13702063.
13: ORIGLIA D. [Research with phenaglycodol in ex-tuberculous subjects with nervous disorders]. G Ital Tuberc Mal Torace. 1960 Nov-Dec;14:373-84. Italian. PMID: 13731154.
14: IMBERCIADORI E. [Early results of the use of 2-p-chlorophenyl-3-methyl-2,3-butanediol (phenaglycodol) in neuropsychiatric therapy]. Minerva Med. 1960 Mar 3;51:757-60. Italian. PMID: 13852743.
15: SETTEL E. An analysis of the analgesic effect of dextropro-poxyphene hydrochloride, phenaglycodol, and aspirin combination (darvo-tran). Antibiotic Med Clin Ther (New York). 1959 Sep;6:512-7. PMID: 14445201.
16: ZUKIN P, ARNOLD DG, KESSLER CR. Comparative effects of phenaglycodol and meprobamate on anxiety reactions. J Nerv Ment Dis. 1959 Aug;129:193-5. doi: 10.1097/00005053-195908000-00009. PMID: 13847900.
17: CIMA L, FASSINA G. [Identification and urinary elimination of phenaglycodol]. Farmaco Prat. 1959 Jul;14:416-23. Italian. PMID: 13849393.
18: QUADRIO A. Alcune osservazioni sperimentali sull'azione del fenaglicodol su talune funzioni psichiche [Various experimental notes on the effect of phenaglycodol on several mental functions]. Clin Ter. 1959 Jun;16(6):583-9. Italian. PMID: 13671735.
19: BALASSI GP, BLANDA F. Sulle possibilità d'impiego in campo ostetricoginecologico di un nuovo centrolettico psicoplegico: il fenaglicodol [Possibility of use in obstetrics & gynecology of a new psychoplegic centroleptic drugs: phenaglycodol]. Riv Ostet Ginecol Prat. 1959 May;41(5):496-502. Italian. PMID: 13675727.
20: GANGLOFF H. Effect of phenaglycodol and meprobamate on spontaneous brain activity, evoked EEG arousal and recruitment in the cat. J Pharmacol Exp Ther. 1959 May;126(1):30-40. PMID: 13642284.
