D159687 | CAS#1155877-97-6 | PDE4D allosteric modulator

MedKoo Cat#: 561733 | Name: D159687

Description:

WARNING: This product is for research use only, not for human or veterinary use.

D159687 is a selective negative allosteric modulator (NAM) of PDE4D.

Chemical Structure

D159687

CAS#1155877-97-6

Theoretical Analysis

MedKoo Cat#: 561733

Name: D159687

CAS#: 1155877-97-6

Chemical Formula: C21H19ClN2O2

Exact Mass: 366.1135

Molecular Weight: 366.84

Elemental Analysis: C, 68.76; H, 5.22; Cl, 9.66; N, 7.64; O, 8.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

D159687; D-159687; D 159687;

IUPAC/Chemical Name

[4-[[3-(3-Chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea

InChi Key

RJJLUTWHJUDZFP-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H19ClN2O2/c1-26-20-10-7-15(12-19(20)16-3-2-4-17(22)13-16)11-14-5-8-18(9-6-14)24-21(23)25/h2-10,12-13H,11H2,1H3,(H3,23,24,25)

SMILES Code

O=C(N)NC1=CC=C(CC2=CC=C(OC)C(C3=CC=CC(Cl)=C3)=C2)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 366.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Titus DJ, Wilson NM, Alcazar O, Calixte DA, Dalton Dietrich W, Gurney ME, Atkins CM. A Negative Allosteric Modulator of PDE4D Enhances Learning after Traumatic Brain Injury. Neurobiol Learn Mem. 2017 Dec 30. pii: S1074-7427(17)30216-2. doi: 10.1016/j.nlm.2017.12.008. [Epub ahead of print] PubMed PMID: 29294383. 2: Zhang C, Xu Y, Zhang HT, Gurney ME, O'Donnell JM. Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System. Sci Rep. 2017 Jan 5;7:40115. doi: 10.1038/srep40115. PubMed PMID: 28054669; PubMed Central PMCID: PMC5215650. 3: Sutcliffe JS, Beaumont V, Watson JM, Chew CS, Beconi M, Hutcheson DM, Dominguez C, Munoz-Sanjuan I. Efficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis). PLoS One. 2014 Jul 22;9(7):e102449. doi: 10.1371/journal.pone.0102449. eCollection 2014. PubMed PMID: 25050979; PubMed Central PMCID: PMC4106781. 4: Burgin AB, Magnusson OT, Singh J, Witte P, Staker BL, Bjornsson JM, Thorsteinsdottir M, Hrafnsdottir S, Hagen T, Kiselyov AS, Stewart LJ, Gurney ME. Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat Biotechnol. 2010 Jan;28(1):63-70. doi: 10.1038/nbt.1598. Epub 2009 Dec 27. PubMed PMID: 20037581.