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MedKoo Cat#: 561708 | Name: Thioflavin T
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thioflavin T is a widely used dye for visualizing and quantifying the presence of misfolded protein aggregates called amyloid, both in vitro and in vivo.

Chemical Structure

Thioflavin T
Thioflavin T
CAS#2390-54-7

Theoretical Analysis

MedKoo Cat#: 561708

Name: Thioflavin T

CAS#: 2390-54-7

Chemical Formula: C17H19ClN2S

Exact Mass: 318.0957

Molecular Weight: 318.86

Elemental Analysis: C, 64.04; H, 6.01; Cl, 11.12; N, 8.79; S, 10.05

Price and Availability

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25g USD 210.00
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Related CAS #
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Synonym
Thioflavin T; Basic yellow 1; Thioflavin S; Setoflavine T;
IUPAC/Chemical Name
4-(3,6-Dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline chloride
InChi Key
JADVWWSKYZXRGX-UHFFFAOYSA-M
InChi Code
InChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
SMILES Code
CN(C)C1=CC=C(C2=[N+](C)C3=CC=C(C)C=C3S2)C=C1.[Cl-]
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
View CoA: current batch, Lot#A23M12B27
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 318.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schlein M. Insulin Formulation Characterization-the Thioflavin T Assays. AAPS J. 2017 Mar;19(2):397-408. doi: 10.1208/s12248-016-0028-6. Epub 2016 Dec 20. Review. PubMed PMID: 28000098. 2: Patel KA, Sethi R, Dhara AR, Roy I. Challenges with osmolytes as inhibitors of protein aggregation: Can nucleic acid aptamers provide an answer? Int J Biol Macromol. 2017 Jul;100:75-88. doi: 10.1016/j.ijbiomac.2016.05.014. Epub 2016 May 6. Review. PubMed PMID: 27156694. 3: Matías-Guiu JA, Oreja-Guevara C, Cabrera-Martín MN, Moreno-Ramos T, Carreras JL, Matías-Guiu J. Amyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET Imaging. Front Neurol. 2016 Mar 31;7:53. doi: 10.3389/fneur.2016.00053. eCollection 2016. Review. PubMed PMID: 27065425; PubMed Central PMCID: PMC4814935. 4: Xu MM, Ren WM, Tang XC, Hu YH, Zhang HY. Advances in development of fluorescent probes for detecting amyloid-β aggregates. Acta Pharmacol Sin. 2016 Jun;37(6):719-30. doi: 10.1038/aps.2015.155. Epub 2016 Mar 21. Review. PubMed PMID: 26997567; PubMed Central PMCID: PMC4954760. 5: Naiki H, Okoshi T, Ozawa D, Yamaguchi I, Hasegawa K. Molecular pathogenesis of human amyloidosis: Lessons from β2 -microglobulin-related amyloidosis. Pathol Int. 2016 Apr;66(4):193-201. doi: 10.1111/pin.12394. Epub 2016 Mar 11. Review. PubMed PMID: 26969800. 6: Radko SP, Khmeleva SA, Suprun EV, Kozin SA, Bodoev NV, Makarov AA, Archakov AI, Shumyantseva VV. [Physico-chemical methods for studing β-amyloid aggregation]. Biomed Khim. 2015 Mar-Apr;61(2):203-18. doi: 10.18097/PBMC20156102203. Review. Russian. PubMed PMID: 25978387. 7: Repalli J, Meruelo D. Screening strategies to identify HSP70 modulators to treat Alzheimer's disease. Drug Des Devel Ther. 2015 Jan 7;9:321-31. doi: 10.2147/DDDT.S72165. eCollection 2015. Review. PubMed PMID: 25609918; PubMed Central PMCID: PMC4294646. 8: Batzli KM, Love BJ. Agitation of amyloid proteins to speed aggregation measured by ThT fluorescence: a call for standardization. Mater Sci Eng C Mater Biol Appl. 2015 Mar;48:359-64. doi: 10.1016/j.msec.2014.09.015. Epub 2014 Sep 16. Review. PubMed PMID: 25579934. 9: Kumar NS, Nisha N. Phytomedicines as potential inhibitors of β amyloid aggregation: significance to Alzheimer's disease. Chin J Nat Med. 2014 Nov;12(11):801-18. doi: 10.1016/S1875-5364(14)60122-9. Review. PubMed PMID: 25480511. 10: Yang Y, Cui M. Radiolabeled bioactive benzoheterocycles for imaging β-amyloid plaques in Alzheimer's disease. Eur J Med Chem. 2014 Nov 24;87:703-21. doi: 10.1016/j.ejmech.2014.10.012. Epub 2014 Oct 7. Review. PubMed PMID: 25305715. 11: Romero D, Kolter R. Functional amyloids in bacteria. Int Microbiol. 2014 Jun;17(2):65-73. doi: 10.2436/20.1501.01.208. Review. PubMed PMID: 26418850. 12: Aulić S, Bolognesi ML, Legname G. Small-molecule theranostic probes: a promising future in neurodegenerative diseases. Int J Cell Biol. 2013;2013:150952. doi: 10.1155/2013/150952. Epub 2013 Nov 12. Review. PubMed PMID: 24324497; PubMed Central PMCID: PMC3845517. 13: Noël S, Cadet S, Gras E, Hureau C. The benzazole scaffold: a SWAT to combat Alzheimer's disease. Chem Soc Rev. 2013 Oct 7;42(19):7747-62. doi: 10.1039/c3cs60086f. Epub 2013 Jun 24. Review. PubMed PMID: 23793644. 14: Veloso A, Kerman K. Advances in electrochemical detection for study of neurodegenerative disorders. Anal Bioanal Chem. 2013 Jul;405(17):5725-41. doi: 10.1007/s00216-013-6904-3. Epub 2013 Mar 26. Review. PubMed PMID: 23529415. 15: Chopra A. 2-{3-[(18)F]Fluoro-4-(methylamino)phenyl}-1,3-benzothiazol-6-ol. 2012 Nov 14 [updated 2012 Dec 27]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK115136/ PubMed PMID: 23285496. 16: Leung K. 2-(4-(2-[(18)F]Fluoroethyl)piperidin-1-yl)benzo[4,5]imidazo[1,2-a]pyrimidine. 2012 Sep 27 [updated 2012 Dec 12]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK114830/ PubMed PMID: 23256221. 17: Benseny-Cases N, Klementieva O, Cladera J. In vitro oligomerization and fibrillogenesis of amyloid-beta peptides. Subcell Biochem. 2012;65:53-74. doi: 10.1007/978-94-007-5416-4_3. Review. PubMed PMID: 23224999. 18: Jameson LP, Smith NW, Dzyuba SV. Dye-binding assays for evaluation of the effects of small molecule inhibitors on amyloid (aβ) self-assembly. ACS Chem Neurosci. 2012 Nov 21;3(11):807-19. doi: 10.1021/cn300076x. Epub 2012 Aug 6. Review. PubMed PMID: 23173064; PubMed Central PMCID: PMC3503347. 19: Leung K. 5-(2E,4E)-5-(6-hydroxy-4-oxo-2-thioxo-1,2,3,4-tetrahydroxy-5 pyrimidinyl)-2,4-pentadienylidene-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione. 2012 Jul 1 [updated 2012 Oct 25]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK109729/ PubMed PMID: 23115807. 20: Mathis CA, Mason NS, Lopresti BJ, Klunk WE. Development of positron emission tomography β-amyloid plaque imaging agents. Semin Nucl Med. 2012 Nov;42(6):423-32. doi: 10.1053/j.semnuclmed.2012.07.001. Review. PubMed PMID: 23026364; PubMed Central PMCID: PMC3520098.