MedKoo Cat#: 527034 | Name: INI-43

Description:

WARNING: This product is for research use only, not for human or veterinary use.

INI-43 is a novel Inhibitor of Nuclear Import-43, showing a significant cytotoxic effect on various cervical and oesophageal cancer cell lines by targeting Kpnß1.

Chemical Structure

INI-43
INI-43
CAS#881046-01-1

Theoretical Analysis

MedKoo Cat#: 527034

Name: INI-43

CAS#: 881046-01-1

Chemical Formula: C22H23N7

Exact Mass: 385.2015

Molecular Weight: 385.48

Elemental Analysis: C, 68.55; H, 6.01; N, 25.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
INI 43; INI43; INI-43
IUPAC/Chemical Name
3-(1H-Benzimidazol-2-yl)-1-(3-dimethylaminopropyl)pyrrolo[5,4-b]quinoxalin-2-amine
InChi Key
LWPQQQAILAUWTI-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H23N7/c1-28(2)12-7-13-29-20(23)18(21-25-15-9-4-5-10-16(15)26-21)19-22(29)27-17-11-6-3-8-14(17)24-19/h3-6,8-11H,7,12-13,23H2,1-2H3,(H,25,26)
SMILES Code
NC1=C(C2=NC3=CC=CC=C3N2)C4=NC5=CC=CC=C5N=C4N1CCCN(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 385.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Stelma T, Leaner VD. KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells. Oncotarget. 2017 May 16;8(20):32833-32847. doi: 10.18632/oncotarget.15834. PubMed PMID: 28427184; PubMed Central PMCID: PMC5464831. 2: van der Watt PJ, Chi A, Stelma T, Stowell C, Strydom E, Carden S, Angus L, Hadley K, Lang D, Wei W, Birrer MJ, Trent JO, Leaner VD. Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic. Mol Cancer Ther. 2016 Apr;15(4):560-73. doi: 10.1158/1535-7163.MCT-15-0052. Epub 2016 Feb 1. PubMed PMID: 26832790.