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MedKoo Cat#: 561691 | Name: Carminomycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carminomycin is an anthracycline antineoplastic antibiotic. It intercalates into DNA and interacting with topoisomerase II, thereby inhibiting DNA replication and repair along with RNA and protein synthesis.

Chemical Structure

Carminomycin
Carminomycin
CAS#39472-31-6

Theoretical Analysis

MedKoo Cat#: 561691

Name: Carminomycin

CAS#: 39472-31-6

Chemical Formula: C26H27NO10

Exact Mass: 513.1635

Molecular Weight: 513.49

Elemental Analysis: C, 60.82; H, 5.30; N, 2.73; O, 31.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Carminomycin;
IUPAC/Chemical Name
(7S,9S)-9-Acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-4,6,9,11-tetrahydroxy-8,10-dihydro-7H-tetracene-5,12-dione
InChi Key
XREUEWVEMYWFFA-CSKJXFQVSA-N
InChi Code
InChI=1S/C26H27NO10/c1-9-21(30)13(27)6-16(36-9)37-15-8-26(35,10(2)28)7-12-18(15)25(34)20-19(23(12)32)22(31)11-4-3-5-14(29)17(11)24(20)33/h3-5,9,13,15-16,21,29-30,32,34-35H,6-8,27H2,1-2H3/t9-,13-,15-,16-,21+,26-/m0/s1
SMILES Code
O=C1C2=C(O)C([C@@H](O[C@@H]3O[C@@H](C)[C@@H](O)[C@@H](N)C3)C[C@](O)(C(C)=O)C4)=C4C(O)=C2C(C5=C1C(O)=CC=C5)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 513.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Monneret C. Recent developments in the field of antitumour anthracyclines. Eur J Med Chem. 2001 Jun;36(6):483-93. Review. PubMed PMID: 11525839. 2: Brandes AA, Pasetto LM, Monfardini S. New drugs in recurrent high grade gliomas. Anticancer Res. 2000 May-Jun;20(3B):1913-20. Review. PubMed PMID: 10928126. 3: Ohnishi K, Ohno R. [New antitumor drugs for malignant lymphoma: a review]. Gan To Kagaku Ryoho. 1994 Jul;21(8):1157-62. Review. Japanese. PubMed PMID: 8031156. 4: Ogawa M, Ariyoshi Y. [New anthracyclines]. Gan To Kagaku Ryoho. 1993 Jan;20(1):27-33. Review. Japanese. PubMed PMID: 8422185. 5: Muggia FM, Green MD. New anthracycline antitumor antibiotics. Crit Rev Oncol Hematol. 1991;11(1):43-64. Review. PubMed PMID: 1831987. 6: Olsuf'eva EN. [Synthesis and antitumor activity of new analogs of anthracycline antibiotics modified by aglycon]. Bioorg Khim. 1990 Nov;16(11):1445-64. Review. Russian. PubMed PMID: 2096823. 7: Otake N. [The structure and antitumor activity of antitumor antibiotics--recent progress]. Gan To Kagaku Ryoho. 1988 Mar;15(3):369-79. Review. Japanese. PubMed PMID: 3279909. 8: Young CW, Raymond V. Clinical assessment of the structure-activity relationship of anthracyclines and related synthetic derivatives. Cancer Treat Rep. 1986 Jan;70(1):51-63. Review. PubMed PMID: 2935251. 9: Romanini A, Febi G, Danesi R, Del Tacca M. [Recent pharmacotoxicologic and clinical findings on adriamycin]. Minerva Med. 1985 Oct 20;76(40):1863-76. Review. Italian. PubMed PMID: 2997664. 10: Lambertenghi-Deliliers G, Colajori E, Annaloro C, Polli EE. [Therapy of acute leukemia: contribution of the new anthracyclinic drugs]. Recenti Prog Med. 1985 Jul-Aug;76(7-8):392-7. Review. Italian. PubMed PMID: 3906794. 11: Ogawa M. [Current status of clinical results of new antitumor drugs]. Gan To Kagaku Ryoho. 1985 Feb;12(2):179-88. Review. Japanese. PubMed PMID: 3918502. 12: Young RC, Ozols RF, Myers CE. The anthracycline antineoplastic drugs. N Engl J Med. 1981 Jul 16;305(3):139-53. Review. PubMed PMID: 7017406. 13: Korol'chuk VP, Shipilov VI, Romanov VA, Matveev BP. [Chemotherapy of bladder cancer]. Urol Nefrol (Mosk). 1981 May-Jun;(3):68-72. Review. Russian. PubMed PMID: 6168085. 14: Gause GF. Antitumor antibiotic carminomycin. Z Allg Mikrobiol. 1980;20(3):219-25. Review. PubMed PMID: 6158803. 15: Brazhnikova MG, Dudnik YV. Chemistry and mechanisms of action of antitumor antibiotics. Natl Cancer Inst Monogr. 1977 Mar;(45):207-12. Review. PubMed PMID: 337152. 16: Crooke ST. A review of carminomycin-a new anthracycline developed in the USSR. J Med. 1977;8(5):295-316. Review. PubMed PMID: 338849.

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