MedKoo Cat#: 555105 | Name: BTT-3033
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BTT-3033 is a α2β1 integrin inhibitor. BTT-3033 blocks platelet attachment under flow (90 dynes/cm(2)). The action of BTT-3033, unlike that of BTT-3034, was dependent on Tyr-285.

Chemical Structure

BTT-3033
BTT-3033
CAS#1259028-99-3

Theoretical Analysis

MedKoo Cat#: 555105

Name: BTT-3033

CAS#: 1259028-99-3

Chemical Formula: C23H20FN5O3S

Exact Mass: 465.1271

Molecular Weight: 465.50

Elemental Analysis: C, 59.35; H, 4.33; F, 4.08; N, 15.05; O, 10.31; S, 6.89

Price and Availability

Size Price Availability Quantity
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,650.00 2 Weeks
500mg USD 2,850.00 2 Weeks
1g USD 3,850.00 2 Weeks
2g USD 5,950.00 2 Weeks
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Related CAS #
No Data
Synonym
BTT-3033; BTT 3033; BTT3033.
IUPAC/Chemical Name
1-(4-Fluorophenyl)-N-methyl-N-(4-(3-phenylureido)phenyl)-1H-pyrazole-4-sulfonamide
InChi Key
NSLIQOPYDUKWTA-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H20FN5O3S/c1-28(33(31,32)22-15-25-29(16-22)21-11-7-17(24)8-12-21)20-13-9-19(10-14-20)27-23(30)26-18-5-3-2-4-6-18/h2-16H,1H3,(H2,26,27,30)
SMILES Code
O=S(C1=CN(C2=CC=C(F)C=C2)N=C1)(N(C)C3=CC=C(NC(NC4=CC=CC=C4)=O)C=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
The interaction between α2β1 integrin (GPIa/IIa, VLA-2) and vascular collagen is one of the initiating events in thrombus formatio
Certificate of Analysis
Safety Data Sheet (SDS)

Preparing Stock Solutions

The following data is based on the product molecular weight 465.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nissinen L, Koivunen J, Käpylä J, Salmela M, Nieminen J, Jokinen J, Sipilä K, Pihlavisto M, Pentikäinen OT, Marjamäki A, Heino J. Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J Biol Chem. 2012 Dec 28;287(53):44694-702. doi: 10.1074/jbc.M111.309450. Epub 2012 Nov 6. PubMed PMID: 23132859; PubMed Central PMCID: PMC3531784.