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MedKoo Cat#: 526598 | Name: Ro 48-8587

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 48-8587 is a competitive AMPA receptor antagonist.

Chemical Structure

Ro 48-8587
Ro 48-8587
CAS#211120-62-6

Theoretical Analysis

MedKoo Cat#: 526598

Name: Ro 48-8587

CAS#: 211120-62-6

Chemical Formula: C12H7N7O4

Exact Mass: 313.0560

Molecular Weight: 313.23

Elemental Analysis: C, 46.01; H, 2.25; N, 31.30; O, 20.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ro 48-8587; Ro 488587; Ro 48 8587
IUPAC/Chemical Name
9-Imidazol-1-yl-8-nitro-2,3,5,6-tetrahydro[1,2,4]-triazolo[1,5-c]quinazoline-2,5-dione
InChi Key
AVTCDZCFLPMWQN-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H7N7O4/c20-11-15-10-6-3-8(17-2-1-13-5-17)9(19(22)23)4-7(6)14-12(21)18(10)16-11/h1-5H,(H,14,21)(H,16,20)
SMILES Code
O=C1NN2C(NC3=C(C=C(N4C=CN=C4)C([N+]([O-])=O)=C3)C2=N1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 313.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Morin N, Morissette M, Grégoire L, Gomez-Mancilla B, Gasparini F, Di Paolo T. Chronic treatment with MPEP, an mGlu5 receptor antagonist, normalizes basal ganglia glutamate neurotransmission in L-DOPA-treated parkinsonian monkeys. Neuropharmacology. 2013 Oct;73:216-31. doi: 10.1016/j.neuropharm.2013.05.028. Epub 2013 Jun 10. PubMed PMID: 23756168. 2: Firstova IuIu, Vasil'eva EV, Kovalev GI. [Studying specific effects of nootropic drugs on glutamate receptors in the rat brain]. Eksp Klin Farmakol. 2011;74(1):6-10. Russian. PubMed PMID: 21476267. 3: Ouattara B, Hoyer D, Grégoire L, Morissette M, Gasparini F, Gomez-Mancilla B, Di Paolo T. Changes of AMPA receptors in MPTP monkeys with levodopa-induced dyskinesias. Neuroscience. 2010 Jun 2;167(4):1160-7. doi: 10.1016/j.neuroscience.2010.03.022. Epub 2010 Mar 18. PubMed PMID: 20303391. 4: Allison C, Pratt JA. Differential effects of two chronic diazepam treatment regimes on withdrawal anxiety and AMPA receptor characteristics. Neuropsychopharmacology. 2006 Mar;31(3):602-19. PubMed PMID: 15970947. 5: Allison C, Pratt JA, Ripley TL, Stephens DN. alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionate receptor autoradiography in mouse brain after single and repeated withdrawal from diazepam. Eur J Neurosci. 2005 Feb;21(4):1045-56. PubMed PMID: 15787709. 6: Jouppila A, Pentikäinen OT, Settimo L, Nyrönen T, Haapalahti JP, Lampinen M, Mottershead DG, Johnson MS, Keinänen K. Determinants of antagonist binding at the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit, GluR-D. Role of the conserved arginine 507 and glutamate 727 residues. Eur J Biochem. 2002 Dec;269(24):6261-70. PubMed PMID: 12473122. 7: Quirk JC, Linden AM, Strakhova M, Yu H, Skolnick P, Nisenbaum ES. A single residue contributes sensitivity to allosteric modulation of AMPA receptors by LY395153. Eur J Pharmacol. 2002 Nov 15;454(2-3):125-9. PubMed PMID: 12421639. 8: Lampinen M, Settimo L, Pentikainen OT, Jouppila A, Mottershead DG, Johnson MS, Keinanen K. Discrimination between agonists and antagonists by the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-selective glutamate receptor. A mutation analysis of the ligand-binding domain of GluR-D subunit. J Biol Chem. 2002 Nov 1;277(44):41940-7. Epub 2002 Aug 7. PubMed PMID: 12167621. 9: Mutel V, Ellis GJ, Adam G, Chaboz S, Nilly A, Messer J, Bleuel Z, Metzler V, Malherbe P, Schlaeger EJ, Roughley BS, Faull RL, Richards JG. Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. PubMed PMID: 11080213. 10: Mutel V, Trube G, Klingelschmidt A, Messer J, Bleuel Z, Humbel U, Clifford MM, Ellis GJ, Richards JG. Binding characteristics of a potent AMPA receptor antagonist [3H]Ro 48-8587 in rat brain. J Neurochem. 1998 Jul;71(1):418-26. PubMed PMID: 9648892.

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