BMS-8 | CAS#1675201-90-7

MedKoo Cat#: 526593 | Name: BMS-8

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface, binding at a hydrophobic cavity formed upon PD-L1 dimerization.

Chemical Structure

BMS-8

CAS#1675201-90-7

Theoretical Analysis

MedKoo Cat#: 526593

Name: BMS-8

CAS#: 1675201-90-7

Chemical Formula: C27H28BrNO3

Exact Mass: 493.1253

Molecular Weight: 494.43

Elemental Analysis: C, 65.59; H, 5.71; Br, 16.16; N, 2.83; O, 9.71

Price and Availability

Size	Price	Availability
5mg	USD 300.00	2 Weeks
10mg	USD 550.00	2 Weeks
25mg	USD 950.00	2 Weeks

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Related CAS #

No Data

Synonym

BMS8; BMS 8; BMS-8

IUPAC/Chemical Name

1-[3-Bromo-4-(2-methyl-biphenyl-3-ylmethoxy)-benzyl]-piperidine-2-carboxylic acid

InChi Key

QRXBPPWUGITQLE-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H28BrNO3/c1-19-22(10-7-11-23(19)21-8-3-2-4-9-21)18-32-26-14-13-20(16-24(26)28)17-29-15-6-5-12-25(29)27(30)31/h2-4,7-11,13-14,16,25H,5-6,12,15,17-18H2,1H3,(H,30,31)

SMILES Code

O=C(C1N(CC2=CC=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C(Br)=C2)CCCC1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Certificate of Analysis

View CoA: current batch, Lot#A20O12B09

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 494.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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