MedKoo Cat#: 526591 | Name: 6-Hydroxy-DL-DOPA
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52, inhibiting proliferation of BRCA-deficient cancer cells in vitro, also inhibiting APE1.

Chemical Structure

6-Hydroxy-DL-DOPA
6-Hydroxy-DL-DOPA
CAS#21373-30-8

Theoretical Analysis

MedKoo Cat#: 526591

Name: 6-Hydroxy-DL-DOPA

CAS#: 21373-30-8

Chemical Formula: C9H11NO5

Exact Mass: 213.0637

Molecular Weight: 213.19

Elemental Analysis: C, 50.71; H, 5.20; N, 6.57; O, 37.52

Price and Availability

Size Price Availability Quantity
10mg USD 550.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
6-Hydroxy-DL-DOPA
IUPAC/Chemical Name
2,5-Dihydroxy-DL-tyrosine
InChi Key
YLKRUSPZOTYMAT-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15)
SMILES Code
NC(CC1=CC(O)=C(O)C=C1O)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 213.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chandramouly G, McDevitt S, Sullivan K, Kent T, Luz A, Glickman JF, Andrake M, Skorski T, Pomerantz RT. Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem Biol. 2015 Nov 19;22(11):1491-1504. doi: 10.1016/j.chembiol.2015.10.003. Epub 2015 Nov 5. PubMed PMID: 26548611; PubMed Central PMCID: PMC4701204. 2: Simeonov A, Kulkarni A, Dorjsuren D, Jadhav A, Shen M, McNeill DR, Austin CP, Wilson DM 3rd. Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One. 2009 Jun 1;4(6):e5740. doi: 10.1371/journal.pone.0005740. PubMed PMID: 19484131; PubMed Central PMCID: PMC2685009.