Synonym
AC-119; AC 119; AC119
IUPAC/Chemical Name
1H-Purine-2,6-dione, 7-(2-(ethylamino)ethyl)-3,7-dihydro-1,3-dimethyl-8-(phenylmethyl)-
InChi Key
DWVLBZMSEOBQDH-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H23N5O2/c1-4-19-10-11-23-14(12-13-8-6-5-7-9-13)20-16-15(23)17(24)22(3)18(25)21(16)2/h5-9,19H,4,10-12H2,1-3H3
SMILES Code
O=C(N1C)N(C)C2=C(N(CCNCC)C(CC3=CC=CC=C3)=N2)C1=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
341.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Schiantarelli P, Acerbi D, Botta GC, Bonati L, Capelli P, Rondelli I. Evidence of pulmonary tropism of bamifylline and its main active metabolite. Arzneimittelforschung. 1989 Feb;39(2):215-9. PubMed PMID: 2730690.
2: Ohkawa T, Washburn JO, Sitapara R, Sid E, Volkman LE. Specific binding of Autographa californica M nucleopolyhedrovirus occlusion-derived virus to midgut cells of Heliothis virescens larvae is mediated by products of pif genes Ac119 and Ac022 but not by Ac115. J Virol. 2005 Dec;79(24):15258-64. PubMed PMID: 16306597; PubMed Central PMCID: PMC1316039.
3: Segre G, Cerretani D, Moltoni L, Urso R, Fusillo M. Pharmacokinetics of bamifylline during chronic therapy. Arzneimittelforschung. 1990 Apr;40(4):450-2. PubMed PMID: 2357245.
4: Jesus Barreto de Melo Rêgo M, Layssa Batista de Sena W, de Moura RO, Tenório Jacob IT, Lins E Lins TU, Pereia MC, Carmo Alves de Lima MD, Galdino-Pitta MR, Rocha Pitta ID, da Rocha Pitta MG. Synthesis and Anticancer Evaluation of Thiazacridine Derivatives Reveals New Selective Molecules to Hematopoietic Neoplastic Cells. Comb Chem High Throughput Screen. 2017 Jul 24. doi: 10.2174/1386207320666170724114802. [Epub ahead of print] PubMed PMID: 28738767.
