MedKoo Cat#: 561645 | Name: Hyodeoxycholic acid sodium salt
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hyodeoxycholic acid sodium salt is a natural secondary bile acid. It improves high-density lipoprotein (HDL) function, reduces farnesoid X receptor antagonist bile acids and the gene expression levels of sterol regulatory element binding protein 1c, acetyl-CoA carboxylase, fatty acid synthase, and stearoyl-CoA desaturase-1, and induces strong cytotoxicity, apoptosis and IL-8 synthesis.

Chemical Structure

Hyodeoxycholic acid sodium salt
Hyodeoxycholic acid sodium salt
CAS#10421-49-5

Theoretical Analysis

MedKoo Cat#: 561645

Name: Hyodeoxycholic acid sodium salt

CAS#: 10421-49-5

Chemical Formula: C24H40O4

Exact Mass: 392.2927

Molecular Weight: 392.58

Elemental Analysis: C, 73.43; H, 10.27; O, 16.30

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
25g USD 650.00 2 Weeks
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Synonym
Hyodeoxycholic acid sodium salt; HDCA sodium; Sodium hyodeoxycholate;
IUPAC/Chemical Name
3alpha,6alpha-Dihydroxy-5 beta,cholan-24-oic acid
InChi Key
DGABKXLVXPYZII-SIBKNCMHSA-N
InChi Code
InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
SMILES Code
C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 392.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Peng LQ, Cao J, Du LJ, Zhang QD, Xu JJ, Chen YB, Shi YT, Li RR. Rapid ultrasonic and microwave-assisted micellar extraction of zingiberone, shogaol and gingerols from gingers using biosurfactants. J Chromatogr A. 2017 Sep 15;1515:37-44. doi: 10.1016/j.chroma.2017.07.092. Epub 2017 Aug 1. PubMed PMID: 28789800. 2: Zhao DS, Jiang LL, Fan YX, Dong LC, Ma J, Dong X, Xu XJ, Li P, Li HJ. Identification of urine tauro-β-muricholic acid as a promising biomarker in Polygoni Multiflori Radix-induced hepatotoxicity by targeted metabolomics of bile acids. Food Chem Toxicol. 2017 Oct;108(Pt B):532-542. doi: 10.1016/j.fct.2017.02.030. Epub 2017 Feb 24. PubMed PMID: 28237774. 3: Fu ZD, Klaassen CD. Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice. Toxicol Appl Pharmacol. 2013 Dec 15;273(3):680-90. doi: 10.1016/j.taap.2013.10.020. Epub 2013 Oct 29. PubMed PMID: 24183703; PubMed Central PMCID: PMC4132937. 4: Zhang Y, Csanaky IL, Selwyn FP, Lehman-McKeeman LD, Klaassen CD. Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism. Biochem Pharmacol. 2013 Aug 1;86(3):437-45. doi: 10.1016/j.bcp.2013.05.020. Epub 2013 Jun 6. PubMed PMID: 23747753; PubMed Central PMCID: PMC3774164. 5: Matsuoka K, Takagi K, Honda C. Micelle formation of sodium hyodeoxycholate. Chem Phys Lipids. 2013 Jul-Aug;172-173:6-13. doi: 10.1016/j.chemphyslip.2013.04.003. Epub 2013 May 7. PubMed PMID: 23665117. 6: Kakiyama G, Muto A, Shimada M, Mano N, Goto J, Hofmann AF, Iida T. Chemical synthesis of 3beta-sulfooxy-7beta-hydroxy-24-nor-5-cholenoic acid: an internal standard for mass spectrometric analysis of the abnormal delta5-bile acids occurring in Niemann-Pick disease. Steroids. 2009 Sep;74(9):766-72. doi: 10.1016/j.steroids.2009.04.007. Epub 2009 Apr 24. PubMed PMID: 19394355. 7: Cohen BI, Ayyad N, Mosbach EH, McSherry CK, Matoba N, Hofmann AF, Ton-Nu HT, Peng Y, Schteingart CD, Stenger RJ. Replacement of cholesterol gallstones by murideoxycholyl taurine gallstones in prairie dogs fed murideoxycholic acid. Hepatology. 1991 Jul;14(1):158-68. PubMed PMID: 2066064. 8: Marshall SE, Marples BA, Salt WG, Stretton RJ. Aspects of the effect of bile salts on Candida albicans. J Med Vet Mycol. 1987 Oct;25(5):307-18. PubMed PMID: 3323449.