Synonym
Benoxacor; BRN 4190275; BRN-4190275; BRN4190275
IUPAC/Chemical Name
2,2-Dichloro-1-(3-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)ethanone
InChi Key
PFJJMJDEVDLPNE-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H11Cl2NO2/c1-7-6-16-9-5-3-2-4-8(9)14(7)11(15)10(12)13/h2-5,7,10H,6H2,1H3
SMILES Code
CC1COC2=CC=CC=C2N1C(C(Cl)Cl)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
260.11
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bolyard K, Gresens SE, Ricko AN, Sivey JD, Salice CJ. Assessing the toxicity of the "inert" safener benoxacor toward Chironomus riparius: Effects of agrochemical mixtures. Environ Toxicol Chem. 2017 Oct;36(10):2660-2670. doi: 10.1002/etc.3814. Epub 2017 Jun 22. PubMed PMID: 28370367.
2: Bedos C, Alletto L, Durand B, Fanucci O, Brut A, Bourdat-Deschamps M, Giuliano S, Loubet B, Ceschia E, Benoit P. Observed volatilization fluxes of S-metolachlor and benoxacor applied on soil with and without crop residues. Environ Sci Pollut Res Int. 2017 Feb;24(4):3985-3996. doi: 10.1007/s11356-016-8124-9. Epub 2016 Dec 3. PubMed PMID: 27915427.
3: Joly P, Bonnemoy F, Charvy JC, Bohatier J, Mallet C. Toxicity assessment of the maize herbicides S-metolachlor, benoxacor, mesotrione and nicosulfuron, and their corresponding commercial formulations, alone and in mixtures, using the Microtox(®) test. Chemosphere. 2013 Nov;93(10):2444-50. doi: 10.1016/j.chemosphere.2013.08.074. Epub 2013 Sep 26. PubMed PMID: 24075530.
4: Del Buono D, Scarponi L, Espen L. Glutathione S-transferases in Festuca arundinacea: identification, characterization and inducibility by safener benoxacor. Phytochemistry. 2007 Nov;68(21):2614-24. Epub 2007 Jul 20. PubMed PMID: 17640691.
5: Del Buono D, Scarponi L, D'Amato R. An analytical method for the simultaneous determination of butachlor and benoxacor in wheat and soil. J Agric Food Chem. 2005 Jun 1;53(11):4326-30. PubMed PMID: 15913290.
6: Scarponi L, Del Buono D. Benoxacor induction of terbuthylazine detoxification in Zea mays and Festuca arundinacea. J Agric Food Chem. 2005 Apr 6;53(7):2483-8. PubMed PMID: 15796583.
7: Smith AP, DeRidder BP, Guo WJ, Seeley EH, Regnier FE, Goldsbrough PB. Proteomic analysis of Arabidopsis glutathione S-transferases from benoxacor- and copper-treated seedlings. J Biol Chem. 2004 Jun 18;279(25):26098-104. Epub 2004 Apr 6. PubMed PMID: 15069083.
8: Fuerst EP, Irzyk GP, Miller KD. Partial Characterization of Glutathione S-Transferase Isozymes Induced by the Herbicide Safener Benoxacor in Maize. Plant Physiol. 1993 Jul;102(3):795-802. PubMed PMID: 12231867; PubMed Central PMCID: PMC158849.
9: Irzyk GP, Fuerst EP. Purification and characterization of a glutathione S-transferase from benoxacor-treated maize (Zea mays). Plant Physiol. 1993 Jul;102(3):803-10. PubMed PMID: 8278534; PubMed Central PMCID: PMC158850.
