MedKoo Cat#: 526432 | Name: ND-378

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ND-378 is a potent and selective slow-binding inhibitor of MMP-2 that does not inhibit the closely related MMP-9 and MMP-14.

Chemical Structure

ND-378
ND-378
CAS#1807453-72-0

Theoretical Analysis

MedKoo Cat#: 526432

Name: ND-378

CAS#: 1807453-72-0

Chemical Formula: C18H31NO4S2

Exact Mass: 389.1700

Molecular Weight: 389.57

Elemental Analysis: C, 55.50; H, 8.02; N, 3.60; O, 16.43; S, 16.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
ND-378
IUPAC/Chemical Name
N-[[4-[4-[(2-Thiiranylmethyl)sulfonyl]phenoxy]phenyl]methyl]-acetamide
InChi Key
QLLPIEIZUZPYLR-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H31NO4S2/c1-13(20)19-10-14-2-4-15(5-3-14)23-16-6-8-18(9-7-16)25(21,22)12-17-11-24-17/h14-18H,2-12H2,1H3,(H,19,20)
SMILES Code
O=C(C)NCC1CCC(OC2CCC(S(=O)(CC3CS3)=O)CC2)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 389.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gao M, Zhang H, Trivedi A, Mahasenan KV, Schroeder VA, Wolter WR, Suckow MA, Mobashery S, Noble-Haeusslein LJ, Chang M. Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury. ACS Chem Neurosci. 2016 Nov 16;7(11):1482-1487. Epub 2016 Aug 25. PubMed PMID: 27551907. 2: Tulve NS, Egeghy PP, Fortmann RC, Whitaker DA, Nishioka MG, Naeher LP, Hilliard A. Multimedia measurements and activity patterns in an observational pilot study of nine young children. J Expo Sci Environ Epidemiol. 2008 Jan;18(1):31-44. Epub 2007 Sep 12. PubMed PMID: 17851450.