BDF 9148 | CAS#120838-62-2 | Cardiovascular Agent

MedKoo Cat#: 584134 | Name: BDF 9148

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BDF 9148 is a Na(+)-channel modulator as well as a congener of DPI 201-106, and was found to increase the contractile force of guinea-pig atria and papillary muscles.

Chemical Structure

BDF 9148

CAS#120838-62-2

Theoretical Analysis

MedKoo Cat#: 584134

Name: BDF 9148

CAS#: 120838-62-2

Chemical Formula: C28H27N3O3

Exact Mass: 453.2052

Molecular Weight: 453.54

Elemental Analysis: C, 74.15; H, 6.00; N, 9.27; O, 10.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

BDF 9148; BDF-9148; BDF9148

IUPAC/Chemical Name

1H-Indole-2-carbonitrile, 4-(3-((1-(diphenylmethyl)-3-azetidinyl)oxy)-2-hydroxypropoxy)-

InChi Key

KQQFGABYYXEKDM-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H27N3O3/c29-15-22-14-25-26(30-22)12-7-13-27(25)34-19-23(32)18-33-24-16-31(17-24)28(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-14,23-24,28,30,32H,16-19H2

SMILES Code

N#CC(N1)=CC2=C1C=CC=C2OCC(O)COC3CN(C(C4=CC=CC=C4)C5=CC=CC=C5)C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 453.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Brixius K, Hoischen S, Zobel C, Lasek K, Schwinger RH. [The Ca(2+) sensitizers CGP 48506 and EMD 57033, but not the Na(+) channel modulator BDF 9148, prolong relaxation in isolated cardiomyocytes of the guinea pig]. Z Kardiol. 2001 Apr;90(4):286-91. German. PubMed PMID: 11381577. 2: Nand V, Doggrell SA. Effects of BDF 9148 on the action potentials and contractions of left ventricles from normo- and hypertensive rats. Clin Exp Pharmacol Physiol. 1999 Mar;26(3):212-9. PubMed PMID: 10081616. 3: Zobel C, Brixius K, Frank K, Schwinger RH. Effect of the Na+-channel modulator BDF 9148 on Ca2+-sensitivity and force of contraction of hypertrophic myocardium from transgene rats harboring the mouse Renin gene (TG(mREN2)27). Naunyn Schmiedebergs Arch Pharmacol. 1998 May;357(5):532-9. PubMed PMID: 9650806. 4: Doggrell SA, Liang LC. The relaxing effect of BDF 9148 on the KCl-contracted aorta isolated from normo- and hyper-tensive rats. Naunyn Schmiedebergs Arch Pharmacol. 1998 Feb;357(2):126-32. PubMed PMID: 9521485. 5: Wahl MA, Anulukanapakorn K, Ammon HP. Effect of a sodium-channel activator (BDF 9148) on insulin secretion in mouse pancreatic islets. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):417-21. PubMed PMID: 9089675. 6: Raap A, Armah B, Mest HJ, Stenzel W, Schloos J, Blechacz W. Investigations of the mechanism of the positive inotropic action of BDF 9148: comparison with DPI 201-106 and the enantiomers. J Cardiovasc Pharmacol. 1997 Feb;29(2):164-73. PubMed PMID: 9057064. 7: Doggrell SA, Bishop BE. Veratridine augments and BDF 9148 attenuates the spontaneous contractile force of the rat portal vein. J Pharm Pharmacol. 1996 Aug;48(8):820-4. PubMed PMID: 8887732. 8: Schwinger RH, Müller-Ehmsen J, Böhm M, Erdmann E. Enantioselective inotropic actions of the Na+-channel activators BDF 9148, BDF 9196 and BDF 9167 in human failing and nonfailing myocardium. J Pharmacol Exp Ther. 1996 Mar;276(3):1180-8. PubMed PMID: 8786551. 9: Hoey A, Nankervis R, Brown L. Positive inotropic responses of the sodium channel modulator BDF 9148 in diseased rat myocardium. Clin Exp Pharmacol Physiol. 1995 Jun-Jul;22(6-7):418-22. PubMed PMID: 8582092. 10: Doggrell SA, Bishop BE, Brosch S. The effects of veratridine and BDF 9148 on the action potentials and contractility of the rat right ventricle. Gen Pharmacol. 1995 May;26(3):593-601. PubMed PMID: 7789734. 11: Amos GJ, Ravens U. The inotropic agents DPI 201-106 and BDF 9148 differentially affect potassium currents of guinea-pig ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 1994 Oct;350(4):426-33. PubMed PMID: 7845480. 12: Hoey A, Amos GJ, Ravens U. Comparison of the action potential prolonging and positive inotropic activity of DPI 201-106 and BDF 9148 in human ventricular myocardium. J Mol Cell Cardiol. 1994 Aug;26(8):985-94. PubMed PMID: 7799453. 13: Hoey A, Amos GJ, Wettwer E, Ravens U. Differential effects of BDF 9148 and DPI 201-106 on action potential and contractility in rat and guinea pig myocardium. J Cardiovasc Pharmacol. 1994 Jun;23(6):907-15. PubMed PMID: 7523782. 14: Baumgart D, Ehring T, Krajcar M, Skyschally A, Heusch G. Characterization of the inotropic and arrhythmogenic action of the sodium channel activator BDF 9148: a comparison to its S-enantiomer BDF 9196, to its congener DPI 201-106, to norepinephrine, and to ouabain. Basic Res Cardiol. 1994 Jan-Feb;89(1):61-79. PubMed PMID: 8010937. 15: Hoey A, Lehmkuhl A, Sadony V, Ravens U. Inotropic actions of BDF 9148 and DPI 201-106 and their enantiomers in guinea-pig, rat and human atria. Eur J Pharmacol. 1993 Feb 16;231(3):477-80. PubMed PMID: 8449239. 16: Ravens U, Wettwer E, Pfeifer T, Himmel H, Armah B. Characterization of the effects of the new inotropic agent BDF 9148 in isolated papillary muscles and myocytes of the guinea-pig heart. Br J Pharmacol. 1991 Dec;104(4):1019-23. PubMed PMID: 1667282; PubMed Central PMCID: PMC1908826. 17: Brasch H, Iven H. Inotropic and electrophysiological effects of BDF 9148, a congener of DPI 201-106, in guinea-pig atria and papillary muscles. Br J Pharmacol. 1991 Aug;103(4):1939-45. PubMed PMID: 1912981; PubMed Central PMCID: PMC1908210. 18: Herzig S, Lilienthal E, Mohr K. The positive inotropic drugs DPI 201-106, BDF 9148, and veratridine increase ouabain toxicity and [3H]ouabain binding in guinea pig heart. J Cardiovasc Pharmacol. 1991 Aug;18(2):182-9. PubMed PMID: 1717777.