Oxprenolol hydrochloride is a non-selective beta-adrenergic blocking agent that also possesses intrinsic sympathomimetic activity (ISA) and membrane stabilizing effects. Oxprenolol hydrochloride undergoes first pass metabolism with only 30% of an oral dose reaching the systemic circulation. The drug is approximately 80% protein bound and is eliminated primarily by glucuronidation in the liver. Less than 4% of oxprenolol hydrochloride is excreted unchanged in the urine. Oxprenolol hydrochloride may reduce the heart rate and prolong the effective and functional atrioventricular nodal refractory period. It appears to be comparable to other beta blockers in the treatment of hypertension and angina pectoris with no additional adverse reactions.
MedKoo Cat#: 584123
Name: Oxprenolol hydrochloride
CAS#: 6452-73-9
Chemical Formula: C15H24ClNO3
Exact Mass:
Molecular Weight: 301.81
Elemental Analysis: C, 59.69; H, 8.02; Cl, 11.75; N, 4.64; O, 15.90
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 33.0 | 109.34 | |
| DMSO | 137.5 | 455.58 | |
| Ethanol | 33.0 | 109.34 | |
| PBS (pH 7.2) | 10.0 | 33.13 | |
| Water | 100.0 | 331.33 |
The following data is based on the product molecular weight 301.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
