GI254023X, also known as GI4023, is a potent and selective ADAM10 Inhibitor with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can remarkably inhibit the proliferation and induce the apoptosis of H929 cells. Its mechanism may be associated with inbihition of Notch1 activation.
MedKoo Cat#: 530998
Name: GI254023X
CAS#: 260264-93-5
Chemical Formula: C21H33N3O4
Exact Mass: 391.2471
Molecular Weight: 391.51
Elemental Analysis: C, 64.42; H, 8.50; N, 10.73; O, 16.35
The following data is based on the product molecular weight 391.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
