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MedKoo Cat#: 561602 | Name: GMQ hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GMQ hydrochloride is a potent and selective modulator of acid-sensing ion channel (ASIC). It activates ASIC3 channels under neutral pH and blocks acid-induced maximal peak current.

Chemical Structure

GMQ hydrochloride
GMQ hydrochloride
CAS#5361-15-9

Theoretical Analysis

MedKoo Cat#: 561602

Name: GMQ hydrochloride

CAS#: 5361-15-9

Chemical Formula: C10H12ClN5

Exact Mass: 0.0000

Molecular Weight: 237.69

Elemental Analysis: C, 50.53; H, 5.09; Cl, 14.91; N, 29.46

Price and Availability

Size Price Availability Quantity
5mg USD 250.00 2 Weeks
10mg USD 450.00 2 Weeks
25mg USD 850.00 2 Weeks
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Synonym
GMQ hydrochloride; GMQ HCl; NSC-403387 HCl; NSC 403387 HCl; NSC403387 HCl;
IUPAC/Chemical Name
1-(4-methylquinazolin-2-yl)guanidine hydrochloride
InChi Key
VNPZWQRWOHFAPD-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H11N5.ClH/c1-6-7-4-2-3-5-8(7)14-10(13-6)15-9(11)12;/h2-5H,1H3,(H4,11,12,13,14,15);1H
SMILES Code
CC1=NC(NC(N)=N)=NC2=C1C=CC=C2.Cl
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
GMQ hydrochloride is a selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4.
In vitro activity:
The guanidine compound GMQ antagonized the GABA-mediated response in a concentration-dependent manner with a determined GMQ IC50 value of 13.2 ± 0.6 and Hill coefficient of 1.4 ± 0.1 (n ≥ 4) (Fig. 4, A and D; Table 2). Reference: J Pharmacol Exp Ther. 2015 Jun;353(3):551-9. https://pubmed.ncbi.nlm.nih.gov/25829529/
In vivo activity:
NGF aggravated tooth mechanical hyperalgesia that could be alleviated by ASIC3 antagonist (APETx2). Moreover, NGF neutralizing antibody mitigated tooth mechanical hyperalgesia that could be recapitulated by ASIC3 agonist (GMQ). Reference: Int J Oral Sci. 2021 Jun 4;13(1):18. https://pubmed.ncbi.nlm.nih.gov/34088898/

Preparing Stock Solutions

The following data is based on the product molecular weight 237.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Snell HD, Gonzales EB. Amiloride and GMQ Allosteric Modulation of the GABA-A ρ1 Receptor: Influences of the Intersubunit Site. J Pharmacol Exp Ther. 2015 Jun;353(3):551-9. doi: 10.1124/jpet.115.222802. Epub 2015 Mar 31. PMID: 25829529; PMCID: PMC4429676. 2. Yan J, Wei X, Bischoff C, Edelmayer RM, Dussor G. pH-evoked dural afferent signaling is mediated by ASIC3 and is sensitized by mast cell mediators. Headache. 2013 Sep;53(8):1250-61. doi: 10.1111/head.12152. Epub 2013 Jun 28. PMID: 23808707; PMCID: PMC3773053. 3. Gao M, Yan X, Lu Y, Ren L, Zhang S, Zhang X, Kuang Q, Liu L, Zhou J, Wang Y, Lai W, Long H. Retrograde nerve growth factor signaling modulates tooth mechanical hyperalgesia induced by orthodontic tooth movement via acid-sensing ion channel 3. Int J Oral Sci. 2021 Jun 4;13(1):18. doi: 10.1038/s41368-021-00124-6. PMID: 34088898; PMCID: PMC8178420. 4. Izurieta Munoz H, Gonzales EB, Sumien N. Effects of creatine supplementation on nociception in young male and female mice. Pharmacol Rep. 2018 Apr;70(2):316-321. doi: 10.1016/j.pharep.2017.11.002. Epub 2017 Nov 11. PMID: 29477040; PMCID: PMC5882535.
In vitro protocol:
1. Snell HD, Gonzales EB. Amiloride and GMQ Allosteric Modulation of the GABA-A ρ1 Receptor: Influences of the Intersubunit Site. J Pharmacol Exp Ther. 2015 Jun;353(3):551-9. doi: 10.1124/jpet.115.222802. Epub 2015 Mar 31. PMID: 25829529; PMCID: PMC4429676. 2. Yan J, Wei X, Bischoff C, Edelmayer RM, Dussor G. pH-evoked dural afferent signaling is mediated by ASIC3 and is sensitized by mast cell mediators. Headache. 2013 Sep;53(8):1250-61. doi: 10.1111/head.12152. Epub 2013 Jun 28. PMID: 23808707; PMCID: PMC3773053.
In vivo protocol:
1. Gao M, Yan X, Lu Y, Ren L, Zhang S, Zhang X, Kuang Q, Liu L, Zhou J, Wang Y, Lai W, Long H. Retrograde nerve growth factor signaling modulates tooth mechanical hyperalgesia induced by orthodontic tooth movement via acid-sensing ion channel 3. Int J Oral Sci. 2021 Jun 4;13(1):18. doi: 10.1038/s41368-021-00124-6. PMID: 34088898; PMCID: PMC8178420. 2. Izurieta Munoz H, Gonzales EB, Sumien N. Effects of creatine supplementation on nociception in young male and female mice. Pharmacol Rep. 2018 Apr;70(2):316-321. doi: 10.1016/j.pharep.2017.11.002. Epub 2017 Nov 11. PMID: 29477040; PMCID: PMC5882535.
1: Besson T, Lingueglia E, Salinas M. Pharmacological modulation of Acid-Sensing Ion Channels 1a and 3 by amiloride and 2-guanidine-4-methylquinazoline (GMQ). Neuropharmacology. 2017 Oct;125:429-440. doi: 10.1016/j.neuropharm.2017.08.004. Epub 2017 Aug 9. PubMed PMID: 28802647.