SC75741 | CAS#913822-46-5 | NF-kappaB inhibitor

MedKoo Cat#: 530988 | Name: SC75741

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SC75741 is a NF-kappaB inhibitor. SC75741 protects mice against highly pathogenic avian influenza A virus. SC75741 significantly protects mice against infection with highly pathogenic avian influenza A viruses of the H5N1 and H7N7 subtypes. SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance.

Chemical Structure

SC75741

CAS#913822-46-5

Theoretical Analysis

MedKoo Cat#: 530988

Name: SC75741

CAS#: 913822-46-5

Chemical Formula: C29H23N7O2S2

Exact Mass: 565.1355

Molecular Weight: 565.67

Elemental Analysis: C, 61.58; H, 4.10; N, 17.33; O, 5.66; S, 11.34

Price and Availability

Size	Price	Availability
50mg	USD 450.00	2 Weeks
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,650.00	2 Weeks
1g	USD 3,750.00	2 Weeks
2g	USD 6,250.00	2 Weeks

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Related CAS #

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Synonym

SC75741; SC-75741; SC 75741.

IUPAC/Chemical Name

N-(6-benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide

InChi Key

QNZVBFMXWNWVKG-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H23N7O2S2/c37-24(17-4-2-1-3-5-17)19-6-7-20-22(14-19)34-29(33-20)35-27(38)23-15-40-28(32-23)18-8-11-36(12-9-18)26-25-21(10-13-39-25)30-16-31-26/h1-7,10,13-16,18H,8-9,11-12H2,(H2,33,34,35,38)

SMILES Code

O=C(C1=CSC(C2CCN(C3=C4C(C=CS4)=NC=N3)CC2)=N1)NC5=NC6=CC=C(C(C7=CC=CC=C7)=O)C=C6N5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

SC75741 is an NF-κB inhibitor with an IC50 of 200 nM for p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 blocks the replication of influenza viruses (IV). SC75741 inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins.

In vitro activity:

SC75741 has potential for targeting the HBx viral protein (associated with the hepatitis B virus) and potentially combating HBV-associated liver conditions. Of 179 compounds studied, SC75741 had a very low docking energy, making it one of the most promising compounds. During simulations, SC75741 robustly inhibited HBx. It exhibited stable interaction and appeared to block a critical region (aa 88-100) near the HBx helix linked to cell invasion. Reference: J Biomol Struct Dyn. 2023 May 30:1-14. https://pubmed.ncbi.nlm.nih.gov/37254310/

In vivo activity:

SC75741 has beneficial neuroprotective effects in amyotrophic lateral sclerosis (ALS). SC75741 inhibited NF-κB, which inhibited inflammation-induced aggregation. SC75741 degraded pre- aggregated proteins by inhibiting the c-Abl mediated autophagy-lysosomal pathway. SC75741 enhanced the interaction between p62 with TDP25 and LC3C, promoting TDP25 degradation. Reference: Front Pharmacol. 2021 Oct 29;12:741219. https://pubmed.ncbi.nlm.nih.gov/34776962/

	Solvent	mg/mL	mM
Solubility
	DMSO	83.3	147.31

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 565.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Hamadalnil Y, Altayb HN. In silico molecular study of hepatitis B virus X protein as a therapeutic target. J Biomol Struct Dyn. 2023 May 30:1-14. doi: 10.1080/07391102.2023.2217920. Epub ahead of print. PMID: 37254310. 2. Zhong H, Yu H, Chen J, Mok SWF, Tan X, Zhao B, He S, Lan L, Fu X, Chen G, Zhu D. The short-chain fatty acid butyrate accelerates vascular calcification via regulation of histone deacetylases and NF-κB signaling. Vascul Pharmacol. 2022 Oct;146:107096. doi: 10.1016/j.vph.2022.107096. Epub 2022 Aug 8. PMID: 35952961. 3. Zhou D, Yan H, Yang S, Zhang Y, Xu X, Cen X, Lei K, Xia H. SC75741, A Novel c-Abl Inhibitor, Promotes the Clearance of TDP25 Aggregates via ATG5-Dependent Autophagy Pathway. Front Pharmacol. 2021 Oct 29;12:741219. doi: 10.3389/fphar.2021.741219. PMID: 34776962; PMCID: PMC8586708. 4. Haasbach E, Reiling SJ, Ehrhardt C, Droebner K, Rückle A, Hrincius ER, Leban J, Strobl S, Vitt D, Ludwig S, Planz O. The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus. Antiviral Res. 2013 Sep;99(3):336-44. doi: 10.1016/j.antiviral.2013.06.008. Epub 2013 Jun 28. PMID: 23811282.

In vitro protocol:

In vivo protocol:

1. Zhou D, Yan H, Yang S, Zhang Y, Xu X, Cen X, Lei K, Xia H. SC75741, A Novel c-Abl Inhibitor, Promotes the Clearance of TDP25 Aggregates via ATG5-Dependent Autophagy Pathway. Front Pharmacol. 2021 Oct 29;12:741219. doi: 10.3389/fphar.2021.741219. PMID: 34776962; PMCID: PMC8586708. 2. Haasbach E, Reiling SJ, Ehrhardt C, Droebner K, Rückle A, Hrincius ER, Leban J, Strobl S, Vitt D, Ludwig S, Planz O. The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus. Antiviral Res. 2013 Sep;99(3):336-44. doi: 10.1016/j.antiviral.2013.06.008. Epub 2013 Jun 28. PMID: 23811282.

1: Sun W, Yang T, Wang C, Li H, Lei L. Mitochondrial ROS participates in Porphyromonas gingivalis-induced pyroptosis in cementoblasts. Heliyon. 2024 May 7;10(9):e30814. doi: 10.1016/j.heliyon.2024.e30814. PMID: 38774076; PMCID: PMC11107101. 2: Rabaan AA, Alshahrani FS, Garout M, Alissa M, Mashraqi MM, Alshehri AA, Alsaleh AA, Alwarthan S, Sabour AA, Alfaraj AH, AlShehail BM, Alotaibi N, Abduljabbar WA, Aljeldah M, Alestad JH. Repositioning of anti-infective compounds against monkeypox virus core cysteine proteinase: a molecular dynamics study. Mol Divers. 2024 Apr 23. doi: 10.1007/s11030-023-10802-8. Epub ahead of print. PMID: 38652365. 3: Wang M, Wang L, Zhou L, Xu Y, Wang C. Shen-Shuai-II-Recipe inhibits tubular inflammation by PPARα-mediated fatty acid oxidation to attenuate fibroblast activation in fibrotic kidneys. Phytomedicine. 2024 Apr;126:155450. doi: 10.1016/j.phymed.2024.155450. Epub 2024 Feb 12. PMID: 38368794. 4: Hamadalnil Y, Altayb HN. In silico molecular study of hepatitis B virus X protein as a therapeutic target. J Biomol Struct Dyn. 2024 May;42(8):4002-4015. doi: 10.1080/07391102.2023.2217920. Epub 2023 May 30. PMID: 37254310. 5: Su J, Yin W, Huo M, Yao Q, Ding L. Induction of apoptosis in glioma cells by lycorine via reactive oxygen species generation and regulation of NF-κB pathways. Naunyn Schmiedebergs Arch Pharmacol. 2023 Jun;396(6):1247-1255. doi: 10.1007/s00210-023-02384-x. Epub 2023 Jan 30. PMID: 36715733. 6: Zhong H, Li DY, Wang SY, Chen JY, Chen JX, Tan X, Wang YH, Xie YC, Zhu DX. [Tanshinone IIa attenuates vascular calcification through inhibition of NF-κB and β-catenin signaling pathways]. Sheng Li Xue Bao. 2022 Dec 25;74(6):949-958. Chinese. PMID: 36594383. 7: Wang XL, Jiao BH, Wu JL, Yang JK, Hu YH, Cui K. Mechanism of RIP2 enhancing stemness of glioma cells induces temozolomide resistance. CNS Neurosci Ther. 2022 Dec;28(12):2319-2330. doi: 10.1111/cns.13981. Epub 2022 Oct 2. PMID: 36184801; PMCID: PMC9627370. 8: Zhong H, Yu H, Chen J, Mok SWF, Tan X, Zhao B, He S, Lan L, Fu X, Chen G, Zhu D. The short-chain fatty acid butyrate accelerates vascular calcification via regulation of histone deacetylases and NF-κB signaling. Vascul Pharmacol. 2022 Oct;146:107096. doi: 10.1016/j.vph.2022.107096. Epub 2022 Aug 8. PMID: 35952961. 9: Li SJ, Cheng WL, Kao YH, Chung CC, Trang NN, Chen YJ. Melatonin Inhibits NF- κB/CREB/Runx2 Signaling and Alleviates Aortic Valve Calcification. Front Cardiovasc Med. 2022 Jun 20;9:885293. doi: 10.3389/fcvm.2022.885293. PMID: 35795373; PMCID: PMC9251177. 10: Li QM, Yang XR, Zha XQ, Pan LH, Zang DD, Zhang FY, Luo JP. Protective Effects of Three Flavonoids from Dendrobium huoshanense Flowers on Alcohol- Induced Hepatocyte Injury via Activating Nrf2 and Inhibiting NF-κB Pathways. Chem Biodivers. 2022 Aug;19(8):e202200471. doi: 10.1002/cbdv.202200471. Epub 2022 Jul 14. PMID: 35774029. 11: Kumari R, Kumar V, Dhankhar P, Dalal V. Promising antivirals for PLpro of SARS-CoV-2 using virtual screening, molecular docking, dynamics, and MMPBSA. J Biomol Struct Dyn. 2023 Jul;41(10):4650-4666. doi: 10.1080/07391102.2022.2071340. Epub 2022 May 5. PMID: 35510600. 12: Zhao Y, Chen R, Xiao D, Zhang L, Song D, Wen Y, Wu R, Zhao Q, Du S, Wen X, Cao S, Huang X. A Comparative Transcriptomic Analysis Reveals That HSP90AB1 Is Involved in the Immune and Inflammatory Responses to Porcine Deltacoronavirus Infection. Int J Mol Sci. 2022 Mar 18;23(6):3280. doi: 10.3390/ijms23063280. PMID: 35328701; PMCID: PMC8953809. 13: Zhou D, Yan H, Yang S, Zhang Y, Xu X, Cen X, Lei K, Xia H. SC75741, A Novel c-Abl Inhibitor, Promotes the Clearance of TDP25 Aggregates via ATG5-Dependent Autophagy Pathway. Front Pharmacol. 2021 Oct 29;12:741219. doi: 10.3389/fphar.2021.741219. PMID: 34776962; PMCID: PMC8586708. 14: Weng PW, Yadav VK, Pikatan NW, Fong IH, Lin IH, Yeh CT, Lee WH. Novel NFκB Inhibitor SC75741 Mitigates Chondrocyte Degradation and Prevents Activated Fibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling. Int J Mol Sci. 2021 Oct 14;22(20):11082. doi: 10.3390/ijms222011082. PMID: 34681754; PMCID: PMC8538686. 15: Tian B, Cai D, Wang M, He T, Deng L, Wu L, Jia R, Zhu D, Liu M, Chen S, Yang Q, Wu Y, Zhao X, Zhang S, Rehman MU, Huang J, Ou X, Mao S, Gao Q, Wen X, Sun D, Yu Y, Zhang L, Liu Y, Pan L, Chen X, Cheng A. SC75741 antagonizes vesicular stomatitis virus, duck Tembusu virus, and duck plague virus infection in duck cells through promoting innate immune responses. Poult Sci. 2021 May;100(5):101085. doi: 10.1016/j.psj.2021.101085. Epub 2021 Mar 2. PMID: 33799115; PMCID: PMC8044693. 16: Guo S, Su Q, Wen J, Zhu K, Tan J, Fu Q, Sun G. S100A9 induces nucleus pulposus cell degeneration through activation of the NF-κB signaling pathway. J Cell Mol Med. 2021 May;25(10):4709-4720. doi: 10.1111/jcmm.16424. Epub 2021 Mar 18. PMID: 33734570; PMCID: PMC8107097. 17: Mendoza CA, Yamaoka S, Tsuda Y, Matsuno K, Weisend CM, Ebihara H. The NF-κB inhibitor, SC75741, is a novel antiviral against emerging tick-borne bandaviruses. Antiviral Res. 2021 Jan;185:104993. doi: 10.1016/j.antiviral.2020.104993. Epub 2020 Dec 6. PMID: 33296695; PMCID: PMC8077392. 18: Zhang LG, Yu ZQ, Yang C, Chen J, Zhan CS, Chen XG, Zhang L, Hao ZY, Liang CZ. Effect of Eriocalyxin B on prostatic inflammation and pelvic pain in a mouse model of experimental autoimmune prostatitis. Prostate. 2020 Dec;80(16):1394-1404. doi: 10.1002/pros.24065. Epub 2020 Sep 23. PMID: 32965686. 19: Chiang Y, Wang CC, Tsai YC, Huang CY, Pu YS, Lin CC, Cheng JC. Nuclear Factor-κB Overexpression is Correlated with Poor Outcomes after Multimodality Bladder-Preserving Therapy in Patients with Muscle-Invasive Bladder Cancer. J Clin Med. 2019 Nov 13;8(11):1954. doi: 10.3390/jcm8111954. PMID: 31766169; PMCID: PMC6912291. 20: He YB, Guo JH, Wang C, Zhu D, Lu LM. IL-33 promotes the progression of nonrheumatic aortic valve stenosis via inducing differential phenotypic transition in valvular interstitial cells. J Cardiol. 2020 Feb;75(2):124-133. doi: 10.1016/j.jjcc.2019.06.011. Epub 2019 Aug 13. PMID: 31416779.