MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 561593 | Name: DL-Phenylephrine HCl
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DL-Phenylephrine HCl is a selective alpha1-adrenergic receptor agonist.

Chemical Structure

DL-Phenylephrine HCl
DL-Phenylephrine HCl
CAS#154-86-9

Theoretical Analysis

MedKoo Cat#: 561593

Name: DL-Phenylephrine HCl

CAS#: 154-86-9

Chemical Formula: C9H14ClNO2

Exact Mass: 0.0000

Molecular Weight: 203.66

Elemental Analysis: C, 53.08; H, 6.93; Cl, 17.41; N, 6.88; O, 15.71

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 550.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
DL-Phenylephrine hydrochloride; DL-Phenylephrine HCl; Eyelo; Matafa-lind; NSC-14029; NSC14029; NSC 14029;
IUPAC/Chemical Name
3-[1-Hydroxy-2-(methylamino)ethyl]phenol hydrochloride
InChi Key
OCYSGIYOVXAGKQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H
SMILES Code
OC1=CC=CC(C(O)CNC)=C1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
DL-Phenylephrine HCl is a selective alpha1-adrenergic receptor agonist.
In vitro activity:
This study confirmed that Linc-RMRP was upregulated in both cardiac hypertrophy tissues and phenylephrine (PE)-induced CH cells, and the cells presented hypertrophic features, enlarged cell surface area and volume, elevated total protein contents, and increased expressions of ANP, BNP, β-MHC, and activated p70S6K and 4EBP1. Reference: J Cardiovasc Pharmacol. 2022 Nov 1;80(5):709-717. https://pubmed.ncbi.nlm.nih.gov/36070614/
In vivo activity:
Phenylephrine significantly increased blood pressure, stroke volume, and total peripheral resistance compared to the mouse vehicle group. Moreover, heart rate was significantly decreased following phenylephrine administration. Reference: Front Physiol. 2022 Feb 17;13:831724. https://pubmed.ncbi.nlm.nih.gov/35250634/

Preparing Stock Solutions

The following data is based on the product molecular weight 203.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Chen J, Li J, Wang X, Zeng Z, Zhang H, Zou Z, Huang N, Sun X. LincRNA RMRP Regulates Phenylephrine-induced Cardiomyocyte Hypertrophy by Means of Targeting miR-1. J Cardiovasc Pharmacol. 2022 Nov 1;80(5):709-717. doi: 10.1097/FJC.0000000000001366. PMID: 36070614. 2. Wang J, Wang Y, Du X, Zhang H. Potassium Channel Conductance Is Involved in Phenylephrine-Induced Spontaneous Firing of Serotonergic Neurons in the Dorsal Raphe Nucleus. Front Cell Neurosci. 2022 Jun 6;16:891912. doi: 10.3389/fncel.2022.891912. PMID: 35734219; PMCID: PMC9207280. 3. Rajanathan R, Pedersen TM, Thomsen MB, Botker HE, Matchkov VV. Phenylephrine-Induced Cardiovascular Changes in the Anesthetized Mouse: An Integrated Assessment of in vivo Hemodynamics Under Conditions of Controlled Heart Rate. Front Physiol. 2022 Feb 17;13:831724. doi: 10.3389/fphys.2022.831724. PMID: 35250634; PMCID: PMC8891648. 4. Qian D, Tian J, Wang S, Shan X, Zhao P, Chen H, Xu M, Guo W, Zhang C, Lu R. Trans-cinnamaldehyde protects against phenylephrine-induced cardiomyocyte hypertrophy through the CaMKII/ERK pathway. BMC Complement Med Ther. 2022 Apr 25;22(1):115. doi: 10.1186/s12906-022-03594-1. PMID: 35468773; PMCID: PMC9040265.
In vitro protocol:
1. Chen J, Li J, Wang X, Zeng Z, Zhang H, Zou Z, Huang N, Sun X. LincRNA RMRP Regulates Phenylephrine-induced Cardiomyocyte Hypertrophy by Means of Targeting miR-1. J Cardiovasc Pharmacol. 2022 Nov 1;80(5):709-717. doi: 10.1097/FJC.0000000000001366. PMID: 36070614. 2. Wang J, Wang Y, Du X, Zhang H. Potassium Channel Conductance Is Involved in Phenylephrine-Induced Spontaneous Firing of Serotonergic Neurons in the Dorsal Raphe Nucleus. Front Cell Neurosci. 2022 Jun 6;16:891912. doi: 10.3389/fncel.2022.891912. PMID: 35734219; PMCID: PMC9207280.
In vivo protocol:
1. Rajanathan R, Pedersen TM, Thomsen MB, Botker HE, Matchkov VV. Phenylephrine-Induced Cardiovascular Changes in the Anesthetized Mouse: An Integrated Assessment of in vivo Hemodynamics Under Conditions of Controlled Heart Rate. Front Physiol. 2022 Feb 17;13:831724. doi: 10.3389/fphys.2022.831724. PMID: 35250634; PMCID: PMC8891648. 2. Qian D, Tian J, Wang S, Shan X, Zhao P, Chen H, Xu M, Guo W, Zhang C, Lu R. Trans-cinnamaldehyde protects against phenylephrine-induced cardiomyocyte hypertrophy through the CaMKII/ERK pathway. BMC Complement Med Ther. 2022 Apr 25;22(1):115. doi: 10.1186/s12906-022-03594-1. PMID: 35468773; PMCID: PMC9040265.

View History

Inocoterone

Inocoterone