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MedKoo Cat#: 561586 | Name: Fluazuron
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fluazuron is an acarine growth inhibitor that also acts as an insect growth regulator.

Chemical Structure

Fluazuron
Fluazuron
CAS#86811-58-7

Theoretical Analysis

MedKoo Cat#: 561586

Name: Fluazuron

CAS#: 86811-58-7

Chemical Formula: C20H10Cl2F5N3O3

Exact Mass: 505.0019

Molecular Weight: 506.21

Elemental Analysis: C, 47.45; H, 1.99; Cl, 14.01; F, 18.77; N, 8.30; O, 9.48

Price and Availability

Size Price Availability Quantity
250mg USD 350.00 2 Weeks
1g USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
Fluazuron; Acatak; Fluazuronum;
IUPAC/Chemical Name
N-[[4-chloro-3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]carbamoyl]-2,6-difluorobenzamide
InChi Key
YOWNVPAUWYHLQX-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H10Cl2F5N3O3/c21-11-5-4-10(29-19(32)30-17(31)16-13(23)2-1-3-14(16)24)7-15(11)33-18-12(22)6-9(8-28-18)20(25,26)27/h1-8H,(H2,29,30,31,32)
SMILES Code
O=C(NC(NC1=CC=C(Cl)C(OC2=NC=C(C(F)(F)F)C=C2Cl)=C1)=O)C3=C(F)C=CC=C3F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 506.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Morel N, Signorini ML, Mangold AJ, Guglielmone AA, Nava S. Strategic control of Rhipicephalus (Boophilus) microplus infestation on beef cattle grazed in Panicum maximum grasses in a subtropical semi-arid region of Argentina. Prev Vet Med. 2017 Sep 1;144:179-183. doi: 10.1016/j.prevetmed.2017.06.006. Epub 2017 Jun 15. PubMed PMID: 28716199. 2: Lopes WDZ, Chiummo RM, Vettorato LF, de Castro Rodrigues D, Sonada RB. The effectiveness of a fixed-dose combination pour-on formulation of 1.25% fipronil and 2.5% fluazuron against economically important ectoparasites and associated pharmacokinetics in cattle. Parasitol Int. 2017 Oct;66(5):627-634. doi: 10.1016/j.parint.2017.05.005. Epub 2017 May 17. PubMed PMID: 28527785. 3: Gaudêncio FN, Klafke GM, Tunholi-Alves VM, Ferreira TP, Coelho CN, da Fonseca AH, da Costa Angelo I, Pinheiro J. Activity of carboxylesterases, glutathione-S-transferase and monooxygenase on Rhipicephalus microplus exposed to fluazuron. Parasitol Int. 2017 Oct;66(5):584-587. doi: 10.1016/j.parint.2017.04.006. Epub 2017 Apr 20. PubMed PMID: 28435029. 4: Zortéa T, Segat JC, Maccari AP, Sousa JP, Da Silva AS, Baretta D. Toxicity of four veterinary pharmaceuticals on the survival and reproduction of Folsomia candida in tropical soils. Chemosphere. 2017 Apr;173:460-465. doi: 10.1016/j.chemosphere.2017.01.069. Epub 2017 Jan 12. PubMed PMID: 28131090. 5: Maciel WG, Lopes WDZ, Gomes LVC, Cruz BC, Felippelli G, Santos IBD, Borges FA, Gonçalves WA Junior, Scarpa AB, Nicaretta JE, Bastos TSA, da Costa AJ. Susceptibility of Rhipicephalus (Boophilus) microplus to fluazuron (2.5mg/kg) and a combination of novaluron (2.0mg/kg)+eprinomectin (0.36mg/kg) in field studies in Brazil. Prev Vet Med. 2016 Dec 1;135:74-86. doi: 10.1016/j.prevetmed.2016.10.019. Epub 2016 Nov 3. PubMed PMID: 27931932. 6: Ke K, Li H, Yao H, Shi XN, Dong C, Zhu Y, Liu X, Li L, Leung KS, Wong MH, Liu XD, Kung HF, Lin MC. In silico prediction and in vitro and in vivo validation of acaricide fluazuron as a potential inhibitor of FGFR3 and a candidate anticancer drug for bladder carcinoma. Chem Biol Drug Des. 2017 Apr;89(4):505-513. doi: 10.1111/cbdd.12872. Epub 2016 Nov 2. PubMed PMID: 27664399. 7: Gaudêncio FN, Tunholi-Alves VM, Lima MG, Gôlo PS, Angelo Ida C, Castro RN, Fonseca AH, Scott FB, Pinheiro J. Alterations in the oxidative metabolism of Rhipicephalus (Boophilus) microplus ticks in response to exposure to the insect growth regulator fluazuron. Rev Bras Parasitol Vet. 2016 Jan-Mar;25(1):54-60. doi: 10.1590/S1984-29612016006. Epub 2016 Mar 11. PubMed PMID: 26982563. 8: Puerta JM, Chaparro JJ, Lopez-Arias A, Arroyave SA, Villar D. Loss of in vitro Efficacy of Topical Commercial Acaricides on Rhipicephalus microplus (Ixodida: Ixodidae) From Antioquian Farms, Colombia. J Med Entomol. 2015 Nov;52(6):1309-14. doi: 10.1093/jme/tjv129. Epub 2015 Aug 19. PubMed PMID: 26336268. 9: Gomes LV, Lopes WD, Cruz BC, Teixeira WF, Felippelli G, Maciel WG, Bichuette MA, Ruivo MA, Alcantara Colli MH, Carvalho RS, Martinez AC, Soares VE, da Costa AJ. Acaricidal effects of fluazuron (2.5 mg/kg) and a combination of fluazuron (1.6 mg/kg) + ivermectin (0.63 mg/kg), administered at different routes, against Rhipicephalus (Boophilus) microplus parasitizing cattle. Exp Parasitol. 2015 Jun;153:22-8. doi: 10.1016/j.exppara.2015.02.004. Epub 2015 Feb 26. PubMed PMID: 25728230. 10: Nava S, Mangold AJ, Canevari JT, Guglielmone AA. Strategic applications of long-acting acaricides against Rhipicephalus (Boophilus) microplus in northwestern Argentina, with an analysis of tick distribution among cattle. Vet Parasitol. 2015 Mar 15;208(3-4):225-30. doi: 10.1016/j.vetpar.2015.01.015. Epub 2015 Jan 28. PubMed PMID: 25670006. 11: Cruz BC, Teixeira WF, Maciel WG, Felippelli G, Fávero FC, Cruz AC, Buzzulini C, Soares VE, Gomes LV, Lopes WD, de Oliveira GP, da Costa AJ. Effects of fluazuron (2.5 mg/kg) and a combination of fluazuron (3.0 mg/kg) + abamectin (0.5 mg/kg) on the reproductive parameters of a field population of Rhipicephalus (Boophilus) microplus on experimentally infested cattle. Res Vet Sci. 2014 Aug;97(1):80-4. doi: 10.1016/j.rvsc.2014.04.012. Epub 2014 May 5. PubMed PMID: 24837997. 12: Reck J, Klafke GM, Webster A, Dall'Agnol B, Scheffer R, Souza UA, Corassini VB, Vargas R, dos Santos JS, Martins JR. First report of fluazuron resistance in Rhipicephalus microplus: a field tick population resistant to six classes of acaricides. Vet Parasitol. 2014 Mar 17;201(1-2):128-36. doi: 10.1016/j.vetpar.2014.01.012. Epub 2014 Jan 29. PubMed PMID: 24560364. 13: de Oliveira PR, Calligaris IB, Nunes PH, Bechara GH, Camargo-Mathias MI. Fluazuron-induced morphological changes in Rhipicephalus sanguineus Latreille, 1806 (Acari: Ixodidae) nymphs: An ultra-structural evaluation of the cuticle formation and digestive processes. Acta Trop. 2014 May;133:45-55. doi: 10.1016/j.actatropica.2014.01.008. Epub 2014 Feb 4. PubMed PMID: 24508101. 14: Chen L, Chen J, Guo Y, Li J, Yang Y, Xu L, Fu F. Study on the simultaneous determination of seven benzoylurea pesticides in Oolong tea and their leaching characteristics during infusing process by HPLC-MS/MS. Food Chem. 2014 Jan 15;143:405-10. doi: 10.1016/j.foodchem.2013.08.027. Epub 2013 Aug 14. PubMed PMID: 24054259. 15: Calligaris IB, De Oliveira PR, Roma GC, Bechara GH, Camargo-Mathias MI. Action of the insect growth regulator fluazuron, the active ingredient of the acaricide Acatak®, in Rhipicephalus sanguineus nymphs (Latreille, 1806) (Acari: Ixodidae). Microsc Res Tech. 2013 Nov;76(11):1177-85. doi: 10.1002/jemt.22282. Epub 2013 Sep 2. PubMed PMID: 24000046. 16: Fourie JJ, Liebenberg JE, Nyangiwe N, Austin C, Horak IG, Bhushan C. The effects of a pour-on formulation of fluazuron 2.5 % and flumethrin 1 % on populations of Rhipicephalus decoloratus and Rhipicephalus microplus both on and off bovine (Bonsmara breed) hosts. Parasitol Res. 2013 Aug;112 Suppl 1:67-79. doi: 10.1007/s00436-013-3282-x. PubMed PMID: 23749085. 17: de Oliveira PR, Calligaris IB, Roma GC, Bechara GH, Camargo-Mathias MI. Fluazuron-induced morphophysiological changes in the cuticle formation and midgut of Rhipicephalus sanguineus Latreille, 1806 (Acari: Ixodidae) nymphs. Parasitol Res. 2013 Jan;112(1):45-58. doi: 10.1007/s00436-012-3103-7. Epub 2012 Sep 20. PubMed PMID: 22992894. 18: de Oliveira PR, Calligaris IB, Roma GC, Bechara GH, Pizano MA, Camargo Mathias MI. Potential of the insect growth regulator, fluazuron, in the control of Rhipicephalus sanguineus nymphs (Latreille, 1806) (Acari: Ixodidae): determination of the LD95 and LD50. Exp Parasitol. 2012 May;131(1):35-9. doi: 10.1016/j.exppara.2012.02.023. Epub 2012 Mar 21. PubMed PMID: 22465612. 19: Pasay C, Rothwell J, Mounsey K, Kelly A, Hutchinson B, Miezler A, McCarthy J. An exploratory study to assess the activity of the acarine growth inhibitor, fluazuron, against Sarcoptes scabei infestation in pigs. Parasit Vectors. 2012 Feb 16;5:40. doi: 10.1186/1756-3305-5-40. PubMed PMID: 22336283; PubMed Central PMCID: PMC3298804. 20: Davis RM, Cleugh E, Smith RT, Fritz CL. Use of a chitin synthesis inhibitor to control fleas on wild rodents important in the maintenance of plague, Yersinia pestis, in California. J Vector Ecol. 2008 Dec;33(2):278-84. PubMed PMID: 19263847.