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MedKoo Cat#: 561573 | Name: Leucomycin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Leucomycin is a macrolide antibiotic that is effective against a wide spectrum of pathogens.

Chemical Structure

Leucomycin
Leucomycin
CAS#1392-21-8

Theoretical Analysis

MedKoo Cat#: 561573

Name: Leucomycin

CAS#: 1392-21-8

Chemical Formula: C35H59NO13

Exact Mass: 701.3900

Molecular Weight: 701.85

Elemental Analysis: C, 59.90; H, 8.47; N, 2.00; O, 29.63

Price and Availability

Size Price Availability Quantity
5g USD 350.00 2 Weeks
25g USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
Ayermicina; C 637; Kitasamycin; Sineptina; Stereomycine; Syneptine; Leucomycin
IUPAC/Chemical Name
2-[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[(2S,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde
InChi Key
XYJOGTQLTFNMQG-KJHBSLKPSA-N
InChi Code
InChI=1S/C35H59NO13/c1-19-16-23(14-15-37)31(32(44-8)25(39)17-26(40)45-20(2)12-10-9-11-13-24(19)38)49-34-29(41)28(36(6)7)30(21(3)47-34)48-27-18-35(5,43)33(42)22(4)46-27/h9-11,13,15,19-25,27-34,38-39,41-43H,12,14,16-18H2,1-8H3/b10-9+,13-11+/t19-,20-,21-,22+,23+,24+,25-,27+,28-,29-,30-,31+,32+,33+,34+,35-/m1/s1
SMILES Code
O=CC[C@@H]1[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@](C)(O)C3)[C@H](N(C)C)[C@H]2O)[C@@H](OC)[C@H](O)CC(O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C1)=O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 701.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li F, Yang B, Miller MJ, Zajicek J, Noll BC, Möllmann U, Dahse HM, Miller PA. Iminonitroso Diels-Alder reactions for efficient derivatization and functionalization of complex diene-containing natural products. Org Lett. 2007 Jul 19;9(15):2923-6. Epub 2007 Jun 30. PubMed PMID: 17602642. 2: Bocker H, Knorre WA. Antibiotica research in Jena from penicillin and nourseothricin to interferon. Adv Biochem Eng Biotechnol. 2000;70:35-40. PubMed PMID: 11092127. 3: Ozegowski JH, Müller PJ. Metabolism of phosphate-limited cultures of Streptomyces. IV. Protein-phosphorylation of antibiotics-producing cultures. Zentralbl Bakteriol. 1993 Jun;279(2):157-66. PubMed PMID: 8219488. 4: Furs AR, Orekhov AV. [Molecular cloning of tylosin-producing Streptomyces fradiae B-45 genes determining increased inducible resistance to tylosin in Streptomyces lividans TK64]. Antibiot Khimioter. 1989 May;34(5):332-7. Russian. PubMed PMID: 2742417. 5: Bache K, Kuhn B, Trolldenier H. [Determination of pharmacokinetic variables in veterinary medicine using a computer program]. Arch Exp Veterinarmed. 1985 May;39(3):296-308. German. PubMed PMID: 3840351. 6: Ozegowski JH, Müller PJ. [Metabolism of phosphate-limited Streptomyces cultures. II. Purification and characterization of acid phosphatase from culture filtrates of turimycin-producing Streptomyces hygroscopicus]. Zentralbl Bakteriol Mikrobiol Hyg A. 1984 Dec;258(2-3):159-72. German. PubMed PMID: 6532020. 7: Ozegowski JH, Müller PJ. [Metabolism of phosphate-limited Streptomyces cultures. I. Purification and characterization of alkaline phosphatase produced by Streptomyces hygroscopicus]. Zentralbl Bakteriol Mikrobiol Hyg A. 1984 Dec;258(2-3):141-55. German. PubMed PMID: 6532019. 8: Hesse G, Hoffmann H, Fricke H, Fleck WF. [Protein binding of the macrolide antibiotic turimycin. Methodologic effects on results]. Pharmazie. 1983 Nov;38(11):740-3. German. PubMed PMID: 6669594. 9: Hoffmann H, Härtl A, Horn U, Kielstein P, Drewello J, Forberg W, Seupel B. [Antimicrobial activity in tissues of swine following subcutaneous administration of turimycin]. Arch Exp Veterinarmed. 1983 Jul;37(4):599-607. German. PubMed PMID: 6651444. 10: Worseck M, Kielstein P, Schimmel D, Fiebig H, Brunneck S. [Activity and minimal inhibitory concentration of turimycin against important pathogens in veterinary medicine]. Arch Exp Veterinarmed. 1983 Jul;37(4):587-97. German. PubMed PMID: 6651443. 11: Effenberger W, Müller PJ, Bocker H. Uncoupling of respiration in turimycin fermentations. Z Allg Mikrobiol. 1983;23(9):557-64. PubMed PMID: 6670296. 12: Zippel M, Neigenfind M, Noack D. Possible plasmid involvement in turimycin production in Streptomyces hygroscopicus. Mol Gen Genet. 1983;192(3):471-6. PubMed PMID: 6581377. 13: Römer W, Müller PJ. Parallel regulation of cAMP phosphodiesterase and phosphatase activities in turimycin fermentations. Z Allg Mikrobiol. 1983;23(3):203-6. PubMed PMID: 6308918. 14: Müller PJ, Ozegowski JH, Bocker H. Regulation of hydrolase formation and phosphate release in turimycin fermentations. Z Allg Mikrobiol. 1983;23(3):173-80. PubMed PMID: 6308916. 15: Roth M, Noack D, Reinhardt G. Properties of non-differentiating derivatives of Streptomyces hygroscopicus. J Gen Microbiol. 1982 Nov;128(11):2687-91. PubMed PMID: 7153761. 16: Müller PJ, Hilliger H, Menner M, Forberg W. Phosphate release in turimycin fermentations. Z Allg Mikrobiol. 1982;22(4):267-72. PubMed PMID: 7123997. 17: Roth M, Noack D. Genetic stability of differentiated functions in Streptomyces hygroscopicus in relation to conditions of continuous culture. J Gen Microbiol. 1982 Jan;128(1):107-14. PubMed PMID: 7045280. 18: Fricke H, Schade W, Härtl A, Drewello S. [Isolation and structure of the main metabolite of macrolide antibiotic turimycin H (author's transl)]. Pharmazie. 1981 Nov;36(11):763-7. German. PubMed PMID: 7323124. 19: Mühlig P, Freysoldt C, Bradler G, Kühne C. [Use of automated image analysis for screening the efficiency of turimycin-producing Streptomyces strains]. Z Allg Mikrobiol. 1981;21(8):591-600. German. PubMed PMID: 7036554. 20: Eritt I, Schumann G, Fleck WF. [Fertility mutants of the turimycin-producing Streptomyces hygroscopicus IMET JA 6599]. Z Allg Mikrobiol. 1981;21(1):27-34. German. PubMed PMID: 7013286.

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