MDK-1699 | Skp2 inhibitor C1 | SKPin C1 | CAS#432001-69-9

MedKoo Cat#: 530690 | Name: MDK-1699

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDK-1699, also known as Skp2 inhibitor C1 and SKPin C1, is a Skp2 inhibitor. MDK-1699 inhibits Skp2-mediated p27 degradation; induces cell cycle arrest.

Chemical Structure

MDK-1699

CAS#432001-69-9

Theoretical Analysis

MedKoo Cat#: 530690

Name: MDK-1699

CAS#: 432001-69-9

Chemical Formula: C18H13BrN2O4S2

Exact Mass: 463.9500

Molecular Weight: 465.34

Elemental Analysis: C, 46.46; H, 2.82; Br, 17.17; N, 6.02; O, 13.75; S, 13.78

Price and Availability

Size	Price	Availability
50mg	USD 350.00	2 Weeks
100mg	USD 650.00	2 Weeks
250mg	USD 1,350.00	2 Weeks
500mg	USD 2,350.00	2 Weeks
1g	USD 3,650.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

MDK-1699; MDK 1699; MDK1699; Skp2 inhibitor C1; SKPin C1

IUPAC/Chemical Name

2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid

InChi Key

O=C(O)COC1=CC=C(Br)C=C1/C=C(SC(N2CC3=CC=CN=C3)=S)/C2=O

InChi Code

InChI=1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7-

SMILES Code

O=C(O)COC1=CC=C(Br)C=C1/C=C(SC(N2CC3=CC=CN=C3)=S)/C2=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	DMSO	10.0	0.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 465.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Yang Y, Yan W, Liu Z, Wei M. Skp2 inhibitor SKPin C1 decreased viability and proliferation of multiple myeloma cells and induced apoptosis. Braz J Med Biol Res. 2019;52(5):e8412. doi: 10.1590/1414-431X20198412. Epub 2019 Apr 25. PMID: 31038581; PMCID: PMC6487740. 2. Li F, Huang C, Lu X, Xiang H, Wang D, Chen Z, Chen J, He H, Yuan X. Identification of the antidepressive properties of C1, a specific inhibitor of Skp2, in mice. Behav Pharmacol. 2021 Feb 1;32(1):62-72. doi: 10.1097/FBP.0000000000000604. PMID: 33416256.