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MedKoo Cat#: 561553 | Name: Tinyatoxin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tinyatoxin is a neurotoxin that acts through the vanilloid receptors of sensory nerves.

Chemical Structure

Tinyatoxin
CAS#58821-95-7

Theoretical Analysis

MedKoo Cat#: 561553

Name: Tinyatoxin

CAS#: 58821-95-7

Chemical Formula: C35H28N4O5

Exact Mass: 584.2060

Molecular Weight: 584.63

Elemental Analysis: C, 71.91; H, 4.83; N, 9.58; O, 13.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tinyatoxin; TTX; TTN; TNX;
IUPAC/Chemical Name
(2-benzyl-6a-hydroxy-8,10-dimethyl-7-oxo-11a-(prop-1-en-2-yl)-3a,3b,6,6a,9a,10,11,11a-octahydro-7H-2,9b-epoxyazuleno[5',4':3,4]benzo[1,2-d][1,3]dioxol-5-yl)methyl 2-(4-hydroxyphenyl)acetate
InChi Key
WWZMXEIBZCEIFB-UHFFFAOYSA-N
InChi Code
InChI=1S/C36H38O8/c1-21(2)34-17-23(4)36-28(32(34)42-35(43-34,44-36)19-25-8-6-5-7-9-25)15-26(18-33(40)29(36)14-22(3)31(33)39)20-41-30(38)16-24-10-12-27(37)13-11-24/h5-15,23,28-29,32,37,40H,1,16-20H2,2-4H3
SMILES Code
C=C(C)C(C1O2)(CC(C)C3(O4)C1C=C(COC(CC5=CC=C(O)C=C5)=O)CC6(O)C3C=C(C)C6=O)OC24CC7=CC=CC=C7
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 584.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: McDonald HA, Neelands TR, Kort M, Han P, Vos MH, Faltynek CR, Moreland RB, Puttfarcken PS. Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia. Eur J Pharmacol. 2008 Oct 31;596(1-3):62-9. doi: 10.1016/j.ejphar.2008.07.063. Epub 2008 Aug 5. PubMed PMID: 18755179. 2: Mannes AJ, Brown DC, Keller J, Cordes L, Eckenhoff RG, Caudle RM, Iadarola MJ, Meng QC. Measurement of resiniferatoxin in serum samples by high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 5;823(2):184-8. PubMed PMID: 16039169. 3: Witte DG, Cassar SC, Masters JN, Esbenshade T, Hancock AA. Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor. J Biomol Screen. 2002 Oct;7(5):466-75. PubMed PMID: 14599363. 4: Fraser MO, Chuang YC, Kim DY, Brady CM, Beckel JM, Yoshimura N, de Groat WC, Chancellor MB. Intravesical ultrapotent vanilloid receptor agonists: acute effects on animal models of bladder irritation. Urology. 2001 Jun;57(6 Suppl 1):111-2. PubMed PMID: 11378080. 5: Geiges D, Meyer T, Marte B, Vanek M, Weissgerber G, Stabel S, Pfeilschifter J, Fabbro D, Huwiler A. Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents. Biochem Pharmacol. 1997 Mar 21;53(6):865-75. PubMed PMID: 9113106. 6: Acs G, Lee J, Marquez VE, Blumberg PM. Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes. Brain Res Mol Brain Res. 1996 Jan;35(1-2):173-82. PubMed PMID: 8717353. 7: Szallasi A, Lewin NA, Blumberg PM. Vanilloid (capsaicin) receptor in the rat: positive cooperativity of resiniferatoxin binding and its modulation by reduction and oxidation. J Pharmacol Exp Ther. 1993 Aug;266(2):678-83. PubMed PMID: 8355200. 8: Szallasi A, Szolcsanyi J, Szallasi Z, Blumberg PM. Inhibition of [3H]resiniferatoxin binding to rat dorsal root ganglion membranes as a novel approach in evaluating compounds with capsaicin-like activity. Naunyn Schmiedebergs Arch Pharmacol. 1991 Nov;344(5):551-6. PubMed PMID: 1811172. 9: Szallasi A, Blumberg PM. Characterization of vanilloid receptors in the dorsal horn of pig spinal cord. Brain Res. 1991 May 3;547(2):335-8. PubMed PMID: 1884211. 10: Williamson EM, Westwick J, Evans FJ. The effect of daphnane esters on platelet aggregation and erythema of the mouse ear. J Pharm Pharmacol. 1980 May;32(5):373-4. PubMed PMID: 6104710.