MedKoo Cat#: 407849 | Name: CIDD-0067106

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CIDD-0067106. has potent and selective antiproliferative activities. Mechanisms of action studies show they inhibit the activity of the mTORC1 pathway. CIDD-0067106 also showed Selective Activity against Androgen Receptor-Positive Breast Cancer Cells.

Chemical Structure

CIDD-0067106
CIDD-0067106
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 407849

Name: CIDD-0067106

CAS#: Unknown

Chemical Formula: C26H29N3O4

Exact Mass: 447.2158

Molecular Weight: 447.54

Elemental Analysis: C, 69.78; H, 6.53; N, 9.39; O, 14.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CIDD-0067106; CIDD 0067106; CIDD0067106.
IUPAC/Chemical Name
methyl ((6-(5-(4-((3-methylbut-2-en-1-yl)oxy)phenyl)oxazol-2-yl)pyridin-3-yl)methyl)-L-prolinate
InChi Key
KWCAEMFGVDPGNT-QHCPKHFHSA-N
InChi Code
InChI=1S/C26H29N3O4/c1-18(2)12-14-32-21-9-7-20(8-10-21)24-16-28-25(33-24)22-11-6-19(15-27-22)17-29-13-4-5-23(29)26(30)31-3/h6-12,15-16,23H,4-5,13-14,17H2,1-3H3/t23-/m0/s1
SMILES Code
C/C(C)=C\COC1=CC=C(C2=CN=C(C3=NC=C(CN4CCC[C@H]4C(OC)=O)C=C3)O2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Targeted therapies for ER+/PR+ and HER2-amplified breast cancers have improved patient survival, but there are no therapies for triple negative breast cancers (TNBC) that lack expression of estrogen and progesterone receptors (ER/PR), or amplification or overexpression of HER2. Gene expression profiling of TNBC has identified molecular subtypes and representative cell lines. An extract of the Texas

Preparing Stock Solutions

The following data is based on the product molecular weight 447.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Robles AJ, McCowen S, Cai S, Glassman M, Ruiz F 2nd, Cichewicz RH, McHardy SF, Mooberry SL. Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells. J Med Chem. 2017 Nov 3. doi: 10.1021/acs.jmedchem.7b01228. [Epub ahead of print] PubMed PMID: 29053266.