MedKoo Cat#: 561531 | Name: TRAP-6
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TRAP-6 is a peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. TRAP-6 stimulates platelet aggregation, promotes intracellular Ca2+ mobilization, and induces rapid phosphodiesterase 3A (PDE3A).

Chemical Structure

TRAP-6
TRAP-6
CAS#141136-83-6

Theoretical Analysis

MedKoo Cat#: 561531

Name: TRAP-6

CAS#: 141136-83-6

Chemical Formula: C34H56N10O9

Exact Mass: 748.4232

Molecular Weight: 748.88

Elemental Analysis: C, 54.53; H, 7.54; N, 18.70; O, 19.23

Price and Availability

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5mg USD 495.00
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Synonym
TRAP-6; TRAP 6; TRAP6; Thrombin receptor activator peptide 6; SFLLRN; SFLLRN-OH; Ser-Phe-Leu-Leu-Arg-Asn;
IUPAC/Chemical Name
L-seryl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-L-asparagine
InChi Key
HAGOWCONESKMDW-FRSCJGFNSA-N
InChi Code
InChI=1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1
SMILES Code
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)=O)[C@H](CO)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 748.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schimmer C, Hamouda K, Sommer SP, Özkur M, Hain J, Leyh R. The predictive value of multiple electrode platelet aggregometry (multiplate) in adult cardiac surgery. Thorac Cardiovasc Surg. 2013 Dec;61(8):733-43. doi: 10.1055/s-0033-1333659. Epub 2013 Feb 18. Review. PubMed PMID: 23420333. 2: Smadja DM, Gaussem P. [Characterization of endothelial progenitor cells and putative strategies to improve their expansion]. J Soc Biol. 2009;203(2):197-207. doi: 10.1051/jbio/2009024. Epub 2009 Jun 16. Review. French. PubMed PMID: 19527634. 3: Smadja DM, Cornet A, Emmerich J, Aiach M, Gaussem P. Endothelial progenitor cells: characterization, in vitro expansion, and prospects for autologous cell therapy. Cell Biol Toxicol. 2007 Jul;23(4):223-39. Epub 2007 Mar 16. Review. PubMed PMID: 17370127. 4: Maryanoff BE, Zhang HC, Andrade-Gordon P, Derian CK. Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1). Curr Med Chem Cardiovasc Hematol Agents. 2003 Mar;1(1):13-36. Review. PubMed PMID: 15317288. 5: Poullis M, Landis RC, Taylor KM. Aprotinin: is it prothrombotic? Perfusion. 2001 Sep;16(5):401-9. Review. PubMed PMID: 11565895.