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MedKoo Cat#: 561530 | Name: Neuromedin N

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin. It binds to neurotensin receptors to regulate guinea pig intestinal smooth muscle contraction. It also produces hypotension in rats and induces hypothermia following central administration in rats in vivo.

Chemical Structure

Neuromedin N
CAS#92169-45-4

Theoretical Analysis

MedKoo Cat#: 561530

Name: Neuromedin N

CAS#: 92169-45-4

Chemical Formula: C38H63N7O8

Exact Mass: 745.4738

Molecular Weight: 745.96

Elemental Analysis: C, 61.19; H, 8.51; N, 13.14; O, 17.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Neuromedin N; Neuromedin-N; KIPYIL; Lys-Ile-Pro-Tyr-Ile-Leu; H-Lys-Ile-Pro-Tyr-Ile-Leu-OH;
IUPAC/Chemical Name
L-lysyl-L-isoleucyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine
InChi Key
RZMLVIHXZGQADB-YLUGYNJDSA-N
InChi Code
InChI=1S/C38H63N7O8/c1-7-23(5)31(36(50)42-29(38(52)53)20-22(3)4)43-34(48)28(21-25-14-16-26(46)17-15-25)41-35(49)30-13-11-19-45(30)37(51)32(24(6)8-2)44-33(47)27(40)12-9-10-18-39/h14-17,22-24,27-32,46H,7-13,18-21,39-40H2,1-6H3,(H,41,49)(H,42,50)(H,43,48)(H,44,47)(H,52,53)/t23-,24-,27-,28-,29-,30-,31-,32-/m0/s1
SMILES Code
O=C(N[C@@H]([C@@H](C)CC)C(N1[C@@H](CCC1)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 745.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fuxe K, Tarakanov A, Romero Fernandez W, Ferraro L, Tanganelli S, Filip M, Agnati LF, Garriga P, Diaz-Cabiale Z, Borroto-Escuela DO. Diversity and Bias through Receptor-Receptor Interactions in GPCR Heteroreceptor Complexes. Focus on Examples from Dopamine D2 Receptor Heteromerization. Front Endocrinol (Lausanne). 2014 May 13;5:71. doi: 10.3389/fendo.2014.00071. eCollection 2014. Review. PubMed PMID: 24860548; PubMed Central PMCID: PMC4026686. 2: Kitabgi P. Neurotensin and neuromedin N are differentially processed from a common precursor by prohormone convertases in tissues and cell lines. Results Probl Cell Differ. 2010;50:85-96. doi: 10.1007/400_2009_27. Review. PubMed PMID: 19862492. 3: Kitabgi P. Inactivation of neurotensin and neuromedin N by Zn metallopeptidases. Peptides. 2006 Oct;27(10):2515-22. Epub 2006 Aug 9. Review. PubMed PMID: 16904239. 4: Kitabgi P. Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases. Peptides. 2006 Oct;27(10):2508-14. Epub 2006 Aug 9. Review. PubMed PMID: 16904237. 5: Kitabgi P. Prohormone convertases differentially process pro-neurotensin/neuromedin N in tissues and cell lines. J Mol Med (Berl). 2006 Aug;84(8):628-34. Epub 2006 May 11. Review. PubMed PMID: 16688434. 6: Kinkead B, Nemeroff CB. Novel treatments of schizophrenia: targeting the neurotensin system. CNS Neurol Disord Drug Targets. 2006 Apr;5(2):205-18. Review. PubMed PMID: 16611093. 7: Costentin J. [Pain and its main transmitters]. Ann Pharm Fr. 2000 Mar;58(2):77-83. Review. French. PubMed PMID: 10790600. 8: Kinkead B, Binder EB, Nemeroff CB. Does neurotensin mediate the effects of antipsychotic drugs? Biol Psychiatry. 1999 Aug 1;46(3):340-51. Review. PubMed PMID: 10435199. 9: Vincent JP. Neurotensin receptors: binding properties, transduction pathways, and structure. Cell Mol Neurobiol. 1995 Oct;15(5):501-12. Review. PubMed PMID: 8719037. 10: Kitabgi P, De Nadai F, Rovère C, Bidard JN. Biosynthesis, maturation, release, and degradation of neurotensin and neuromedin N. Ann N Y Acad Sci. 1992;668:30-42. Review. PubMed PMID: 1463273. 11: Dobner PR, Kislauskis E, Bullock BP. Cooperative regulation of neurotensin/neuromedin N gene expression in PC12 cells involves AP-1 transcription factors. Ann N Y Acad Sci. 1992;668:17-29. Review. PubMed PMID: 1463270. 12: Carraway RE, Mitra SP, Spaulding G. Posttranslational processing of the neurotensin/neuromedin-N precursor. Ann N Y Acad Sci. 1992;668:1-16. Review. PubMed PMID: 1463268.