Icanbelimod | CAS#1514888-56-2 | S1P agonist

MedKoo Cat#: 581029 | Name: Icanbelimod

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Icanbelimod (CBP-307, YUN88562), is a selective, potent sphingosine-1-phosphate receptor modulator, particularly targeting S1P1 and S1P5 receptors. It acts as an agonist, promoting internalization of S1P1 to inhibit lymphocyte egress from lymphoid tissues. In in vitro assays, CBP-307 exhibits nanomolar potency with EC₅₀ values of approximately 2.8 nM for human S1P1 and 7.3 nM for S1P5, while showing >1000-fold selectivity over S1P2–S1P4. In preclinical models of multiple sclerosis (e.g., EAE mouse models), oral administration of CBP-307 significantly reduced disease severity by decreasing peripheral lymphocyte counts and inflammatory infiltration in CNS tissues.

Chemical Structure

Icanbelimod

CAS#1514888-56-2

Theoretical Analysis

MedKoo Cat#: 581029

Name: Icanbelimod

CAS#: 1514888-56-2

Chemical Formula: C23H24FN3O3

Exact Mass: 409.1802

Molecular Weight: 409.46

Elemental Analysis: C, 67.47; H, 5.91; F, 4.64; N, 10.26; O, 11.72

Price and Availability

Size	Price	Availability
100mg	USD 1,850.00	2 Weeks
1g	USD 4,650.00	2 Weeks
2g	USD 7,450.00	2 Weeks

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Related CAS #

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Synonym

CBP-307; CBP 307; CBP307; DC10392; DC-10392; DC 10392; S1P-agonist-1; S1p-receptor-agonist-1; YUN88562; YUN 88562; YUN-88562; Icanbelimod; S1p receptor agonist 1

IUPAC/Chemical Name

1-{2-Fluoro-4-[5-(4-isobutyl-phenyl)-[1,2,4]oxadiazol-3-yl]-benzyl}-azetidine-3-carboxylic acid

InChi Key

YBIFMTGYWXNIRZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H24FN3O3/c1-14(2)9-15-3-5-16(6-4-15)22-25-21(26-30-22)17-7-8-18(20(24)10-17)11-27-12-19(13-27)23(28)29/h3-8,10,14,19H,9,11-13H2,1-2H3,(H,28,29)

SMILES Code

O=C(C1CN(CC2=CC=C(C3=NOC(C4=CC=C(CC(C)C)C=C4)=N3)C=C2F)C1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 409.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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