ABD-350 is ligand-induced inhibitor of nuclear factor kappaB phosphorylation. It causes osteoclast apoptosis without effects of biphosphonates such as bone formation inhibition and anabolism of PTH. ABD-350 has potent antiresorptive effects in vitro and in vivo that do not adversely affect osteoblast function. ABD350 prevented ovariectomy-induced bone loss.
MedKoo Cat#: 571353
Name: ABD-350
CAS#: 1117772-52-7
Chemical Formula: C19H22F2O2
Exact Mass: 320.1588
Molecular Weight: 320.38
Elemental Analysis: C, 71.23; H, 6.92; F, 11.86; O, 9.99
The following data is based on the product molecular weight 320.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
