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MedKoo Cat#: 581013 | Name: SU-200

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SU-200, is agonist of TRPV1. Agonist- and Ca2+-dependent Desensitization of TRPV1 Channel Targets the Receptor to Lysosomes for Degradation

Chemical Structure

SU-200
SU-200
CAS#184003-14-3

Theoretical Analysis

MedKoo Cat#: 581013

Name: SU-200

CAS#: 184003-14-3

Chemical Formula: C20H26N2O2S

Exact Mass: 358.1715

Molecular Weight: 358.50

Elemental Analysis: C, 67.01; H, 7.31; N, 7.81; O, 8.93; S, 8.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SU-200; SU 200; SU200.
IUPAC/Chemical Name
N-[[4-(1,1-Dimethylethyl)phenyl]methyl]-N-[(4-hydroxy-3-methoxyphenyl)methyl]-thiourea
InChi Key
MZUDJDFTIMTIHJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H26N2O2S/c1-20(2,3)16-8-5-14(6-9-16)12-22(19(21)25)13-15-7-10-17(23)18(11-15)24-4/h5-11,23H,12-13H2,1-4H3,(H2,21,25)
SMILES Code
S=C(N)N(CC1=CC=C(C(C)(C)C)C=C1)CC2=CC=C(O)C(OC)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 358.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schmiege P, Fine M, Blobel G, Li X. Human TRPML1 channel structures in open and closed conformations. Nature. 2017 Oct 11. doi: 10.1038/nature24036. [Epub ahead of print] PubMed PMID: 29019983. 2: Fukushima A, Mamada K, Iimura A, Ono H. Supraspinal-selective TRPV1 desensitization induced by intracerebroventricular treatment with resiniferatoxin. Sci Rep. 2017 Sep 29;7(1):12452. doi: 10.1038/s41598-017-12717-5. PubMed PMID: 28963471. 3: Phuong TTT, Redmon SN, Yarishkin O, Winter JM, Li DY, Križaj D. Calcium influx through TRPV4 channels modulates the adherens contacts between retinal microvascular endothelial cells. J Physiol. 2017 Sep 26. doi: 10.1113/JP275052. [Epub ahead of print] PubMed PMID: 28949006. 4: Ren L, Chang MJ, Zhang Z, Dhaka A, Guo Z, Cao YQ. Quantitative Analysis of Mouse Dural Afferent Neurons Expressing TRPM8, VGLUT3, and NF200. Headache. 2017 Sep 19. doi: 10.1111/head.13188. [Epub ahead of print] PubMed PMID: 28925503. 5: Punzo F, Tortora C, Di Pinto D, Manzo I, Bellini G, Casale F, Rossi F. Anti-proliferative, pro-apoptotic and anti-invasive effect of EC/EV system in human osteosarcoma. Oncotarget. 2017 Apr 13;8(33):54459-54471. doi: 10.18632/oncotarget.17089. eCollection 2017 Aug 15. PubMed PMID: 28903355; PubMed Central PMCID: PMC5589594. 6: Zhang M, Chi M, Zou H, Tian S, Zhang Z, Wang G. Effects of coadministration of low dose cannabinoid type 2 receptor agonist and morphine on vanilloid receptor 1 expression in a rat model of cancer pain. Mol Med Rep. 2017 Sep 13. doi: 10.3892/mmr.2017.7479. [Epub ahead of print] PubMed PMID: 28901432. 7: Campbell BK, Fillingim RB, Lee S, Brao R, Price DD, Neubert JK. Effects of High-Dose Capsaicin on TMD Subjects: A Randomized Clinical Study. JDR Clin Trans Res. 2017 Jan;2(1):58-65. doi: 10.1177/2380084416675837. Epub 2016 Oct 26. PubMed PMID: 28879245; PubMed Central PMCID: PMC5576044. 8: Mustafa S, Ismael HN. Ethanol potentiates heat response in the carotid artery via TRPV1. Life Sci. 2017 Nov 1;188:83-86. doi: 10.1016/j.lfs.2017.08.037. Epub 2017 Sep 1. PubMed PMID: 28867580. 9: Xing J, Li J. TRPA1 Function in Skeletal Muscle Sensory Neurons Following Femoral Artery Occlusion. Cell Physiol Biochem. 2017 Aug 17;42(6):2307-2317. doi: 10.1159/000480003. [Epub ahead of print] PubMed PMID: 28848196. 10: Leo M, Schulte M, Schmitt LI, Schäfers M, Kleinschnitz C, Hagenacker T. Intrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior. Mediators Inflamm. 2017;2017:2786427. doi: 10.1155/2017/2786427. Epub 2017 Aug 2. PubMed PMID: 28831207; PubMed Central PMCID: PMC5558708. 11: Beckmann H, Richter J, Hill K, Urban N, Lemoine H, Schaefer M. A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels. Cell Calcium. 2017 Sep;66:10-18. doi: 10.1016/j.ceca.2017.05.012. Epub 2017 Jun 2. PubMed PMID: 28807145. 12: Tai Y, Wang C, Wang Z, Liang Y, Du J, He D, Fan X, Jordt SE, Liu B. Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone. Sci Rep. 2017 Aug 8;7(1):7532. doi: 10.1038/s41598-017-07651-5. PubMed PMID: 28790335; PubMed Central PMCID: PMC5548750. 13: Baskaran P, Thyagarajan B. Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads. J Vis Exp. 2017 Jul 21;(125). doi: 10.3791/55625. PubMed PMID: 28784948. 14: Houghton JW, Hans J, Pesaro M, Ley JP, Carpenter GH, Proctor G. Sensory effects of transient receptor potential channel agonists on whole mouth saliva extensional rheology. J Texture Stud. 2017 Aug;48(4):313-317. doi: 10.1111/jtxs.12260. Epub 2017 Mar 14. PubMed PMID: 28766746. 15: Járomi P, Garab D, Hartmann P, Bodnár D, Nyíri S, Sántha P, Boros M, Jancsó G, Szabó A. Capsaicin-induced rapid neutrophil leukocyte activation in the rat urinary bladder microcirculatory bed. Neurourol Urodyn. 2017 Aug 1. doi: 10.1002/nau.23376. [Epub ahead of print] PubMed PMID: 28762564. 16: Richards JR, Lapoint JM, Burillo-Putze G. Cannabinoid hyperemesis syndrome: potential mechanisms for the benefit of capsaicin and hot water hydrotherapy in treatment. Clin Toxicol (Phila). 2017 Jul 21:1-10. doi: 10.1080/15563650.2017.1349910. [Epub ahead of print] PubMed PMID: 28730896. 17: Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K. N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. J Immunol. 2017 Aug 15;199(4):1465-1475. doi: 10.4049/jimmunol.1602151. Epub 2017 Jul 12. PubMed PMID: 28701511; PubMed Central PMCID: PMC5544930. 18: Sakamoto K, Kuroki T, Sagawa T, Ito H, Mori A, Nakahara T, Ishii K. Opioid receptor activation is involved in neuroprotection induced by TRPV1 channel activation against excitotoxicity in the rat retina. Eur J Pharmacol. 2017 Oct 5;812:57-63. doi: 10.1016/j.ejphar.2017.07.002. Epub 2017 Jul 4. PubMed PMID: 28687197. 19: Ives SJ, Park SY, Kwon OS, Gifford JR, Andtbacka RHI, Hyngstrom JR, Richardson RS. TRPV(1) channels in human skeletal muscle feed arteries: implications for vascular function. Exp Physiol. 2017 Sep 1;102(9):1245-1258. doi: 10.1113/EP086223. Epub 2017 Aug 10. PubMed PMID: 28681979; PubMed Central PMCID: PMC5578896. 20: Ruggiero RN, Rossignoli MT, De Ross JB, Hallak JEC, Leite JP, Bueno-Junior LS. Cannabinoids and Vanilloids in Schizophrenia: Neurophysiological Evidence and Directions for Basic Research. Front Pharmacol. 2017 Jun 21;8:399. doi: 10.3389/fphar.2017.00399. eCollection 2017. Review. PubMed PMID: 28680405; PubMed Central PMCID: PMC5478733.