MedKoo Cat#: 571350 | Name: ABD56

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ABD56 is a biochemical that inhibits osteoclast formation and activity in vitro and in vivo. ABD56 causes osteoclast apoptosis through an unknown method, which is most likely inhibition of survival signals such as ERK and NFkappaB, rather than activation of the p38 or Jnk MAPK pathways.

Chemical Structure

ABD56
ABD56
CAS#521294-19-9

Theoretical Analysis

MedKoo Cat#: 571350

Name: ABD56

CAS#: 521294-19-9

Chemical Formula: C17H18O3

Exact Mass: 270.1256

Molecular Weight: 270.33

Elemental Analysis: C, 75.53; H, 6.71; O, 17.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ABD56; ABD-56; ABD 56
IUPAC/Chemical Name
(1,1'-Biphenyl)-4-carboxylic acid, 4-hydroxybutyl ester
InChi Key
ODVRBGUFYYVDEP-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H18O3/c18-12-4-5-13-20-17(19)16-10-8-15(9-11-16)14-6-2-1-3-7-14/h1-3,6-11,18H,4-5,12-13H2
SMILES Code
O=C(C1=CC=C(C2=CC=CC=C2)C=C1)OCCCCO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 270.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Idris AI, Mrak E, Greig I, Guidobono F, Ralston SH, van 't Hof R. ABD56 causes osteoclast apoptosis by inhibiting the NFkappaB and ERK pathways. Biochem Biophys Res Commun. 2008 Jun 20;371(1):94-8. doi: 10.1016/j.bbrc.2008.04.014. Epub 2008 Apr 14. Erratum in: Biochem Biophys Res Commun. 2010 Apr 30;395(2):289. Idris, Aymen [corrected to Idris, Aymen I]. PubMed PMID: 18413146. 2: Idris AI, Greig IR, Bassonga-Landao E, Ralston SH, van 't Hof RJ. Identification of novel biphenyl carboxylic acid derivatives as novel antiresorptive agents that do not impair parathyroid hormone-induced bone formation. Endocrinology. 2009 Jan;150(1):5-13. doi: 10.1210/en.2008-0998. Epub 2008 Sep 4. PubMed PMID: 18772231.