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MedKoo Cat#: 581012 | Name: KR-33494
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

KR-33494 is a fluorescent-tagged and biotin-tagged probe of a potent inhibitor for Fas-mediated cell death (FAF1).

Chemical Structure

KR-33494
KR-33494
CAS#1021497-97-1

Theoretical Analysis

MedKoo Cat#: 581012

Name: KR-33494

CAS#: 1021497-97-1

Chemical Formula: C20H18BrN3O3S

Exact Mass: 459.0252

Molecular Weight: 460.35

Elemental Analysis: C, 52.18; H, 3.94; Br, 17.36; N, 9.13; O, 10.43; S, 6.96

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,250.00 2 Weeks
1g USD 3,250.00 2 Weeks
2g USD 5,250.00 2 Weeks
5g USD 7,650.00 2 Weeks
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Related CAS #
No Data
Synonym
KR-33494; KR33494; KR 33494; KR-33493
IUPAC/Chemical Name
4-[[2-[(4-Bromophenyl)thio]acetyl]amino]-1-(2-phenylethyl)-1H-pyrazole-3-carboxylic acid
InChi Key
ZRLJEHIUGYTTSZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H18BrN3O3S/c21-15-6-8-16(9-7-15)28-13-18(25)22-17-12-24(23-19(17)20(26)27)11-10-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2,(H,22,25)(H,26,27)
SMILES Code
O=C(C1=NN(CCC2=CC=CC=C2)C=C1NC(CSC3=CC=C(Br)C=C3)=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 61.5 133.60
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 460.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Design and synthesis of fluorescent and biotin tagged probes for the study of molecular actions of FAF1 inhibitor. Yoo SE, Yu C, Jung S, Kim E, Kang NS. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1169-72. doi: 10.1016/j.bmcl.2016.01.045. Epub 2016 Jan 18. PMID: 26810261