EY3238 | CAS#1995861-12-5 | JAK2-HDAC dual inhibitor

MedKoo Cat#: 407836 | Name: EY3238

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EY3238 is a JAK2-HDAC dual inhibitor with low nanomolar activity against JAK2 and HDAC6 while also inhibiting HDACs 2 and 10 with IC50 values below 100 nM (JAK2 IC50 = 1.4 nM); HDAC6 IC50 = 2.1 nM; HDAC2 IC50 = 49nM; HDAC10 IC50 = 80 nM.).

Chemical Structure

EY3238

CAS#1995861-12-5

Theoretical Analysis

MedKoo Cat#: 407836

Name: EY3238

CAS#: 1995861-12-5

Chemical Formula: C29H34N4O5

Exact Mass: 518.2529

Molecular Weight: 518.61

Elemental Analysis: C, 67.16; H, 6.61; N, 10.80; O, 15.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

EY3238; EY-3238; EY 3238.

IUPAC/Chemical Name

(E)-7-(6,11-dioxa-3-aza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphan-8-en-44-yloxy)-N-hydroxyheptanamide

InChi Key

IYBYMTCQQMFOHB-AATRIKPKSA-N

InChi Code

InChI=1S/C29H34N4O5/c34-28(33-35)10-3-1-2-4-17-38-27-12-11-25-19-24(27)21-37-16-6-5-15-36-20-22-8-7-9-23(18-22)26-13-14-30-29(31-25)32-26/h5-9,11-14,18-19,35H,1-4,10,15-17,20-21H2,(H,33,34)(H,30,31,32)/b6-5+

SMILES Code

O=C(NO)CCCCCCOC1=CC=C2C=C1COC/C=C/COCC3=CC=CC(C4=NC(N2)=NC=C4)=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 518.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Yang, E. G.; Mustafa, N.; Tan, E. C.; Poulsen, A.; Ramanujulu, P. M.; Chng, W. J.; Yen, J. J.; Dymock, B. W. Design and synthesis of janus kinase 2 (JAK2) and histone deacetlyase (HDAC) bispecific inhibitors based on pacritinib and evidence of dual pathway inhibition in hematological cell lines. J. Med. Chem. 2016, 59, 8233−8262. 2. Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat Lianbin Yao, Nurulhuda Mustafa, Eng Chong Tan, Anders Poulsen, Prachi Singh, Minh-Dao Duong-Thi, Jeannie X. T. Lee, Pondy Murugappan Ramanujulu, Wee Joo Chng, Jeffrey J. Y. Yen, Sten Ohlson, and Brian W. Dymock Publication Date (Web): September 27, 2017 (Article) DOI: 10.1021/acs.jmedchem.7b00678