MedKoo Cat#: 407835 | Name: RHI002-Me
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RHI002-Me is a methylated derivative of RHI002, a selective inhibitor of human RNaseH2.

Chemical Structure

RHI002-Me
RHI002-Me
CAS#314261-66-0

Theoretical Analysis

MedKoo Cat#: 407835

Name: RHI002-Me

CAS#: 314261-66-0

Chemical Formula: C18H19N3O2S2

Exact Mass: 373.0919

Molecular Weight: 373.49

Elemental Analysis: C, 57.89; H, 5.13; N, 11.25; O, 8.57; S, 17.17

Price and Availability

Size Price Availability Quantity
5mg USD 435.00 2 Weeks
10mg USD 725.00 2 Weeks
25mg USD 1,350.00 2 Weeks
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Related CAS #
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Synonym
RHI002-Me; RHI-002-Me; RHI 002-Me.
IUPAC/Chemical Name
N-(Furan-2-ylmethyl)-2-((2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)thio)acetamide
InChi Key
XVDMGXNXMPYLQK-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H19N3O2S2/c1-11-20-17(24-10-15(22)19-9-12-5-4-8-23-12)16-13-6-2-3-7-14(13)25-18(16)21-11/h4-5,8H,2-3,6-7,9-10H2,1H3,(H,19,22)
SMILES Code
O=C(NCC1=CC=CO1)CSC2=C(C3=C(CCCC3)S4)C4=NC(C)=N2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
RHI002-Me ia a methylated analog of RHI002.
In vitro activity:
RHI002 showed selective activity against human RNaseH2. Because RNaseH2 is involved in the etiology of Aicardi-Goutier syndrome and has been suggested as an anticancer drug target, RNaseH2 inhibitor would be useful for investigating the cellular function of this molecule. Reference: Mol Cells. 2013 Sep;36(3):212-8. https://pubmed.ncbi.nlm.nih.gov/24008364/
In vivo activity:
To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 373.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Kim J, Yoon J, Ju M, Lee Y, Kim TH, Kim J, Sommer P, No Z, Cechetto J, Han SJ. Identification of two HIV inhibitors that also inhibit human RNaseH2. Mol Cells. 2013 Sep;36(3):212-8. doi: 10.1007/s10059-013-2348-z. Epub 2013 Sep 2. PMID: 24008364; PMCID: PMC3887976.
In vitro protocol:
1. Kim J, Yoon J, Ju M, Lee Y, Kim TH, Kim J, Sommer P, No Z, Cechetto J, Han SJ. Identification of two HIV inhibitors that also inhibit human RNaseH2. Mol Cells. 2013 Sep;36(3):212-8. doi: 10.1007/s10059-013-2348-z. Epub 2013 Sep 2. PMID: 24008364; PMCID: PMC3887976.
In vivo protocol:
To be determined
1: Kim J, Yoon J, Ju M, Lee Y, Kim TH, Kim J, Sommer P, No Z, Cechetto J, Han SJ. Identification of two HIV inhibitors that also inhibit human RNaseH2. Mol Cells. 2013 Sep;36(3):212-8. doi: 10.1007/s10059-013-2348-z. Epub 2013 Sep 2. PubMed PMID: 24008364; PubMed Central PMCID: PMC3887976.