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MedKoo Cat#: 329852 | Name: Flutazolam

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flutazolam, also known as Coreminal; MS-4101 and Ro 7-6102, is a drug which is a benzodiazepine derivative. It was invented in Japan, and this is the main country in which it has been used medically. It has sedative, muscle relaxant, anticonvulsant, and anxiolytic effects similar to those produced by other benzodiazepine derivatives, and though it's around the same potency as diazepam, it produces a more marked sedation and impaired coordination. It is indicated for the treatment of insomnia. Flutazolam is closely related in structure to another benzodiazepine, haloxazolam. Flutazolam is unscheduled in the USA.

Chemical Structure

Flutazolam
Flutazolam
CAS#27060-91-9

Theoretical Analysis

MedKoo Cat#: 329852

Name: Flutazolam

CAS#: 27060-91-9

Chemical Formula: C19H18ClFN2O3

Exact Mass: 376.0990

Molecular Weight: 376.81

Elemental Analysis: C, 60.56; H, 4.82; Cl, 9.41; F, 5.04; N, 7.43; O, 12.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Flutazolam; Coreminal; MS-4101; MS 4101; MS4101; Ro 7-6102; Ro7-6102; Ro-7-6102.
IUPAC/Chemical Name
10-Chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-3,5-dihydro-2H-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
InChi Key
WMFSSTNVXWNLKI-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H18ClFN2O3/c20-13-5-6-17-15(11-13)19(14-3-1-2-4-16(14)21)22(8-10-26-19)12-18(25)23(17)7-9-24/h1-6,11,24H,7-10,12H2
SMILES Code
O=C1N(CCO)C2=CC=C(Cl)C=C2C(OCC3)(C4=CC=CC=C4F)N3C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 376.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pettersson Bergstrand M, Helander A, Hansson T, Beck O. Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays. Drug Test Anal. 2017 Apr;9(4):640-645. doi: 10.1002/dta.2003. Epub 2016 Jul 1. PubMed PMID: 27366870. 2: Tanaka E, Terada M, Misawa S, Wakasugi C. Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel. J Chromatogr B Biomed Appl. 1996 Jun 28;682(1):173-8. Erratum in: J Chromatogr B Biomed Appl 1998 May 29;709(2):324. PubMed PMID: 8832439. 3: Hamada Y, Kamiya K, Koyama M, Asaka M, Matsushima T, Myazaki T, Kamiya T. [Studies on the clinical significance concerning the changes in serum pepsinogen-I and gastrin levels in aged patients with chronic gastritis]. Hokkaido Igaku Zasshi. 1988 Mar;63(2):178-85. Japanese. PubMed PMID: 2898425. 4: Yashiro T, Kuwayama T, Kawazura H, Suzuki T. [The behavior of 1,4-benzodiazepine drugs in acidic media. IX. Effect of hydrolyzate of flutazolam on the central nervous system]. Yakugaku Zasshi. 1987 Oct;107(10):830-4. Japanese. PubMed PMID: 2894449. 5: Kuwayama T, Kurono Y, Muramatsu T, Yashiro T, Ikeda K. The behavior of 1,4-benzodiazepine drugs in acidic media. V. Kinetics of hydrolysis of flutazolam and haloxazolam in aqueous solution. Chem Pharm Bull (Tokyo). 1986 Jan;34(1):320-6. PubMed PMID: 2870816. 6: Mitsushima T, Ueki S. [Psychopharmacological effects of flutazolam (MS-4101) (author's transl)]. Nihon Yakurigaku Zasshi. 1978 Nov;74(8):959-79. Japanese. PubMed PMID: 750333.

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