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MedKoo Cat#: 561509 | Name: CPYPP
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CPYPP is a small-molecule inhibitor of DOCK guanine nucleotide exchange factors (GEFs). CPYPP may have some efficacy in treating NET-mediated inflammatory disorders.

Chemical Structure

CPYPP
CPYPP
CAS#310460-39-0

Theoretical Analysis

MedKoo Cat#: 561509

Name: CPYPP

CAS#: 310460-39-0

Chemical Formula: C18H13ClN2O2

Exact Mass: 324.0666

Molecular Weight: 324.76

Elemental Analysis: C, 66.57; H, 4.03; Cl, 10.92; N, 8.63; O, 9.85

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 700.00 2 Weeks
50mg USD 1,150.00 2 Weeks
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Related CAS #
No Data
Synonym
CPYPP;
IUPAC/Chemical Name
4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
InChi Key
VVZJFICTTKPNCK-KVDBUQHUSA-N
InChi Code
InChI=1S/C18H13ClN2O2/c19-16-12-5-4-7-13(16)8-6-11-15-17(22)20-21(18(15)23)14-9-2-1-3-10-14/h1-12H,(H,20,22)/b8-6+,15-11+
SMILES Code
O=C(/C1=C\C=C\C2=CC=CC=C2Cl)NN(C3=CC=CC=C3)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 324.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xu X, Su Y, Wu K, Pan F, Wang A. DOCK2 contributes to endotoxemia-induced acute lung injury in mice by activating proinflammatory macrophages. Biochem Pharmacol. 2020 Dec 28;184:114399. doi: 10.1016/j.bcp.2020.114399. Epub ahead of print. PMID: 33382969. 2: Ferrari MG, Ganaie AA, Shabenah A, Mansini AP, Wang L, Murugan P, Davicioni E, Wang J, Deng Y, Hoeppner LH, Warlick CA, Konety BR, Saleem M. Identifying and treating ROBO1-ve /DOCK1+ve prostate cancer: An aggressive cancer subtype prevalent in African American patients. Prostate. 2020 Sep;80(13):1045-1057. doi: 10.1002/pros.24018. Epub 2020 Jul 20. PMID: 32687658; PMCID: PMC7556361. 3: Morikawa M, Tanaka Y, Cho HS, Yoshihara M, Hirokawa N. The Molecular Motor KIF21B Mediates Synaptic Plasticity and Fear Extinction by Terminating Rac1 Activation. Cell Rep. 2018 Jun 26;23(13):3864-3877. doi: 10.1016/j.celrep.2018.05.089. PMID: 29949770. 4: Ferrandez Y, Zhang W, Peurois F, Akendengué L, Blangy A, Zeghouf M, Cherfils J. Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule. Sci Rep. 2017 Oct 31;7(1):14409. doi: 10.1038/s41598-017-13619-2. PMID: 29089502; PMCID: PMC5663973. 5: Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Côté JF, Sumimoto H, Fukui Y. DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation. J Immunol. 2014 Dec 1;193(11):5660-7. doi: 10.4049/jimmunol.1400885. Epub 2014 Oct 22. PMID: 25339677; PMCID: PMC4640904. 6: Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saito N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, Fukui Y. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19(4):488-97. doi: 10.1016/j.chembiol.2012.03.008. PMID: 22520755.