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MedKoo Cat#: 561490 | Name: Maritinone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Maritinone is a novel anti-tuberculosis (anti-TB) agent. It possess an interesting potential for development as a new drug against Mycobacterium tuberculosis, mainly resistant profile strains.

Chemical Structure

Maritinone
Maritinone
CAS#33927-59-2

Theoretical Analysis

MedKoo Cat#: 561490

Name: Maritinone

CAS#: 33927-59-2

Chemical Formula: C22H14O6

Exact Mass: 374.0790

Molecular Weight: 374.34

Elemental Analysis: C, 70.59; H, 3.77; O, 25.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Maritinone;
IUPAC/Chemical Name
5-Hydroxy-8-(4-hydroxy-7-methyl-5,8-dioxonaphthalen-1-yl)-2-methylnaphthalene-1,4-dione
InChi Key
XCRMWTKECYDCOD-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H14O6/c1-9-7-15(25)19-13(23)5-3-11(17(19)21(9)27)12-4-6-14(24)20-16(26)8-10(2)22(28)18(12)20/h3-8,23-24H,1-2H3
SMILES Code
O=C1C(C)=CC(C2=C1C(C(C=CC(O)=C3C(C=C4C)=O)=C3C4=O)=CC=C2O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 374.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ito C, Matsui T, Takano M, Wu TS, Itoigawa M. Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica. Nat Prod Res. 2017 Aug 20:1-6. doi: 10.1080/14786419.2017.1366476. [Epub ahead of print] PubMed PMID: 28823173. 2: Higa M, Takashima Y, Yokaryo H, Harie Y, Suzuka T, Ogihara K. Naphthoquinone Derivatives from Diospyros maritima. Chem Pharm Bull (Tokyo). 2017;65(8):739-745. doi: 10.1248/cpb.c17-00178. PubMed PMID: 28768928. 3: Sharma D, Yadav JP. An Overview of Phytotherapeutic Approaches for the Treatment of Tuberculosis. Mini Rev Med Chem. 2017;17(2):167-183. Review. PubMed PMID: 27145855. 4: Uc-Cachón AH, Borges-Argáez R, Said-Fernández S, Vargas-Villarreal J, González-Salazar F, Méndez-González M, Cáceres-Farfán M, Molina-Salinas GM. Naphthoquinones isolated from Diospyros anisandra exhibit potent activity against pan-resistant first-line drugs Mycobacterium tuberculosis strains. Pulm Pharmacol Ther. 2014 Feb;27(1):114-20. doi: 10.1016/j.pupt.2013.08.001. Epub 2013 Aug 20. PubMed PMID: 23968826. 5: Quintal-Novelo C, Moo-Puc RE, Chale-Dzul J, Cáceres-Farfán M, Mendez-Gonzalez M, Borges-Argáez R. Cytotoxic constituents from the stem bark of Diospyros cuneata Standl. Nat Prod Res. 2013;27(17):1594-7. doi: 10.1080/14786419.2012.738201. Epub 2012 Oct 26. PubMed PMID: 23098219. 6: Whitson EL, Sun H, Thomas CL, Henrich CJ, Sayers TJ, McMahon JB, Griesinger C, McKee TC. Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima. J Nat Prod. 2012 Mar 23;75(3):394-9. doi: 10.1021/np200805z. Epub 2012 Feb 7. PubMed PMID: 22313254; PubMed Central PMCID: PMC3311710. 7: Gu JQ, Graf TN, Lee D, Chai HB, Mi Q, Kardono LB, Setyowati FM, Ismail R, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kroll DJ, Falkinham JO 3rd, Wall ME, Wani MC, Kinghorn AD, Oberlies NH. Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia. J Nat Prod. 2004 Jul;67(7):1156-61. PubMed PMID: 15270571. 8: Lin LC, Yang LL, Chou CJ. Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica. Phytochemistry. 2003 Feb;62(4):619-22. PubMed PMID: 12560036.

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MU-380

MU-380