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MedKoo Cat#: 329847 | Name: Trilaurin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trilaurin is a triacylglycerol found in dietary fats. Trilaurin can be used in cosmetic products as an thickening agent. Trilaurin can be also used to make nanopartice drug formulation.

Chemical Structure

Trilaurin
Trilaurin
CAS#538-24-9

Theoretical Analysis

MedKoo Cat#: 329847

Name: Trilaurin

CAS#: 538-24-9

Chemical Formula: C39H74O6

Exact Mass: 638.5485

Molecular Weight: 639.02

Elemental Analysis: C, 73.30; H, 11.67; O, 15.02

Price and Availability

Size Price Availability Quantity
25g USD 150.00
100g USD 350.00
500g USD 950.00
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Related CAS #
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Synonym
Trilaurin; Glyceryl tridodecanoate; NSC 4061; 1,2,3-Tridodecanoylglycerol; Tridodecanoin; Trilauroylglycerol; Glycerol trilaurate, Glyceryl trilaurate.
IUPAC/Chemical Name
1,2,3-Tridodecanoylglycerol
InChi Key
VMPHSYLJUKZBJJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C39H74O6/c1-4-7-10-13-16-19-22-25-28-31-37(40)43-34-36(45-39(42)33-30-27-24-21-18-15-12-9-6-3)35-44-38(41)32-29-26-23-20-17-14-11-8-5-2/h36H,4-35H2,1-3H3
SMILES Code
CCCCCCCCCCCC(OCC(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 639.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Christophersen PC, Zhang L, Müllertz A, Nielsen HM, Yang M, Mu H. Solid lipid particles for oral delivery of peptide and protein drugs II--the digestion of trilaurin protects desmopressin from proteolytic degradation. Pharm Res. 2014 Sep;31(9):2420-8. doi: 10.1007/s11095-014-1337-z. Epub 2014 Mar 13. PubMed PMID: 24623481. 2: Xu W, Lim SJ, Lee MK. Cellular uptake and antitumour activity of paclitaxel incorporated into trilaurin-based solid lipid nanoparticles in ovarian cancer. J Microencapsul. 2013;30(8):755-61. doi: 10.3109/02652048.2013.788083. Epub 2013 Apr 17. PubMed PMID: 23594306. 3: Fontagné S, Corraze G, Bergot P. Tricaproin, tricaprin and trilaurin are utilized more efficiently than tricaprylin by carp (Cyprinus carpio L.) larvae. J Nutr. 2000 Aug;130(8):2009-15. PubMed PMID: 10917917. 4: Sreenivas A, Sastry PS. Synthesis of trilaurin by developing pisa seeds (Actinodaphne hookeri). Arch Biochem Biophys. 1994 Jun;311(2):229-34. PubMed PMID: 8203885. 5: Wasutrasawat P, Al-Obaidi H, Gaisford S, Lawrence MJ, Warisnoicharoen W. Drug solubilisation in lipid nanoparticles containing high melting point triglycerides. Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):365-71. doi: 10.1016/j.ejpb.2013.04.020. Epub 2013 May 18. PubMed PMID: 23688806. 6: GEYER RP, CHIPMAN J, STARE FJ. Oxidation in vivo of emulsified radioactive trilaurin administered intravenously. J Biol Chem. 1948 Dec;176(3):1469. PubMed PMID: 18100596. 7: Steven BR, Carey S. Nutritional management in patients with chyle leakage: a systematic review. Eur J Clin Nutr. 2015 Jul;69(7):776-80. doi: 10.1038/ejcn.2015.48. Epub 2015 Apr 29. Review. PubMed PMID: 25920423. 8: Mancuso JR, McClements DJ, Decker EA. Iron-accelerated cumene hydroperoxide decomposition in hexadecane and trilaurin emulsions. J Agric Food Chem. 2000 Feb;48(2):213-9. PubMed PMID: 10691618. 9: Zaĭtsev SIu, Aha B, Volchenkova TA, Belov SV, Schneider MP, Ivanov AE. [The study of hydrolysis of new lipid-like substrates and trilaurin in monolayers catalyzed with the lipase from Pseudomonas fluorescens]. Bioorg Khim. 2000 Mar;26(3):224-30. Russian. PubMed PMID: 10816821. 10: GEYER RP, MATTHEWS LW, STARE FJ. Metabolism of emulsified trilaurin (-C1400-) and octanoic acid (-C1400-) by rat tissue slices. J Biol Chem. 1949 Oct;180(3):1037-45. PubMed PMID: 18139198. 11: Johnson W Jr; Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, and glyceryl stearate diacetate. Int J Toxicol. 2001;20 Suppl 4:61-94. Review. PubMed PMID: 11800053. 12: Qureshi OS, Zeb A, Akram M, Kim MS, Kang JH, Kim HS, Majid A, Han I, Chang SY, Bae ON, Kim JK. Enhanced acute anti-inflammatory effects of CORM-2-loaded nanoparticles via sustained carbon monoxide delivery. Eur J Pharm Biopharm. 2016 Nov;108:187-195. doi: 10.1016/j.ejpb.2016.09.008. Epub 2016 Sep 12. PubMed PMID: 27634645. 13: Chen C, Fan T, Jin Y, Zhou Z, Yang Y, Zhu X, Zhang ZR, Zhang Q, Huang Y. Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle-double emulsion method via the combined use of different solid lipids. Nanomedicine (Lond). 2013 Jul;8(7):1085-100. doi: 10.2217/nnm.12.141. Epub 2012 Oct 17. PubMed PMID: 23075315. 14: Christophersen PC, Vaghela D, Müllertz A, Yang M, Nielsen HM, Mu H. Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin. AAPS J. 2014 Jul;16(4):875-83. doi: 10.1208/s12248-014-9619-2. Epub 2014 May 30. PubMed PMID: 24875052; PubMed Central PMCID: PMC4070260. 15: Mohtar N, A K Khan N, Darwis Y. Solid Lipid Nanoparticles of Atovaquone Based on 2(4) Full-Factorial Design. Iran J Pharm Res. 2015 Fall;14(4):989-1000. PubMed PMID: 26664366; PubMed Central PMCID: PMC4673927. 16: Gupta S, Vyas SP. Development and characterization of amphotericin B bearing emulsomes for passive and active macrophage targeting. J Drug Target. 2007 Apr;15(3):206-17. PubMed PMID: 17454358. 17: Carlson TL, Kottke BA. Effect of coconut oil on plasma apo A-I levels in WHHL and NZW rabbits. Biochim Biophys Acta. 1991 Jun 3;1083(3):221-9. PubMed PMID: 2049387. 18: Roskos KV, Tefft JA, Heller J. A morphine-triggered delivery system useful in the treatment of heroin addiction. Clin Mater. 1993;13(1-4):109-19. PubMed PMID: 10146246. 19: Yoshitomi H, Nishihata T, Frederick G, Dillsaver M, Higuchi T. Effect of triglyceride on small intestinal absorption of cefoxitin in rats. J Pharm Pharmacol. 1987 Nov;39(11):887-91. PubMed PMID: 2892911. 20: Pynn CJ, Picardi MV, Nicholson T, Wistuba D, Poets CF, Schleicher E, Perez-Gil J, Bernhard W. Myristate is selectively incorporated into surfactant and decreases dipalmitoylphosphatidylcholine without functional impairment. Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1306-16. doi: 10.1152/ajpregu.00380.2010. Epub 2010 Sep 1. PubMed PMID: 20811010.

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MCUF-651

MCUF-651

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